Adipocytokines and new onset diabetes mellitus after transplantation

Publication date: Available online 31 May 2018Source: Journal of Applied BiomedicineAuthor(s): Dominika Goldmannová, Jaromíra Spurná, Ondřej Krystyník, Jan Schovánek, Lubica Cibičková, David Karásek, Josef ZadražilAbstractBackground and aimDiabetes mellitus is a very common metabolic disease with a rising incidence. It is one of the most serious comorbidities in renal transplant recipients. New-onset diabetes after renal transplantation (NODAT) is associated with poor graft function, higher rates of cardiovascular complications and a poor prognosis. Adipocytokines, synthetized by adipose tissue influence metabolic pathways and disorders in various ways. In this review article, we chose the most researched adipocytokines and evaluated their relationship to posttransplant diabetes mellitus. The aim of this paper is to summarize current knowledge and discuss their perspective role in diagnostics or therapy of the new onset diabetes mellitus after transplantation.Graphical abstract
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research