International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats
Summary Vaspin and omentin are adipose tissue adipokines that have often been related to obesity and its comorbidities. The aim of this study was to investigate the behaviour of serum omentin and vaspin in models of type 2 diabetes. To do this, Wistar rats (~200 g) were randomly divided into two groups: a non‐diabetic group (n = 6) and a diabetic group fed on a high‐fat diet (n = 6) and a low dose of streptozotocin (Sigma®). All procedures were approved by the Brazilian Ethics Committee. Body weight (BW) and food intake were recorded daily. Tail blood glucose levels were assessed at the end of the diabetes induct...
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Cynthia Aparecida de Castro, Karina Ana Silva, Marina Molina Buffo, Karina Nogueira Zambone Pinto, Fernanda de Oliveira Duarte, Keico Okino Nonaka, Fernanda de Freitas An íbal, Ana Cláudia Garcia de Oliveira Duarte Tags: Original Article Source Type: research

Understanding human thiol dioxygenase enzymes: structure to function, and biology to pathology
In this study, we have predicted a 3D model structure for ADO and summarized the biological roles and the pathological consequences which are associated with the altered expression and functioning of ADO and CDO in case of cancer, neurodegenerative disorders and other human diseases. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Bibekananda Sarkar, Mahesh Kulharia, Anil K. Mantha Tags: Review Article Source Type: research

Decreased expression of EphA5 is associated with Fuhrman nuclear grade and pathological tumour stage in ccRCC
In this study, a set of clear cell renal cell carcinoma (ccRCC) tissues were subjected to immunohistochemistry. The relationship between EphA5 protein expression and clinicopathological parameters was statistically analysed. Our data show that EphA5 protein was negatively (0) or weakly (1+) expressed in 48 of 78 (61.5%), moderately (2+) expressed in 15 of 78 (19.2%) and strongly (3+) expressed in 15 of 78 (19.2%) tumour samples of ccRCC. Decreased expression of EphA5 was detected more often in females than in males (P = 0.017, rs = −0.267). Expression of EphA5 was related negatively to Fuhrman grade (P = 0.013, rs�...
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Xiaolin Wang, Haifei Xu, Zhijun Wu, Xiao Chen, Jiandong Wang Tags: Original Article Source Type: research

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(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - October 11, 2016 Category: Pathology Tags: Issue Information Source Type: research

Role of parnaparin in atherosclerosis
Summary Atherosclerosis is characterized by a proliferation of vascular smooth muscle cells (VSMCs) and their migration to the intima, which induces thickening of the intima itself, but the mechanism remains poorly understood. Low molecular weight heparin (LMWH) inhibits the proliferation of VSMCs. Previous studies have shown that a LMWH, parnaparin (PNP), acts on the processes of atherogenesis and atheroprogression in experimental animal models. The aim of this study was to investigate the involvement of oxidative stress, inflammation and VSMCs in the regulation of vascular wall homeostasis. We also considered the possibi...
Source: International Journal of Experimental Pathology - September 30, 2016 Category: Pathology Authors: Francesca Bonomini, Samanta Taurone, Pierpaolo Parnigotto, Loris Zamai, Luigi F. Rodella, Marco Artico, Rita Rezzani Tags: Original Article Source Type: research

Reversal of tubo ‐ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole
Summary Letrozole (LTZ), one of the ovulation induction medications, is increasingly prescribed in various gynaecological conditions. Previous studies have demonstrated its potential hazardous effect on the ovarian surface epithelium (OSE) as well as on tubal epithelial cells (TEC). However, it is not clear whether this effect could be reversed by LTZ cessation. Therefore, the objective of our study was to investigate the effect of stoppage of LTZ on these cells after 12 cycles of ovarian stimulation. A total of 54 Sprague Dawley rats were used in this study, divided equally into control, LTZ12 and CES12 groups (received s...
Source: International Journal of Experimental Pathology - August 31, 2016 Category: Pathology Authors: Ahmed A.M. Abdel ‐Hamid, Yaser Mesbah, Mona F.M. Soliman Tags: Original Article Source Type: research

Regulatory mechanisms of skeletal and connective tissue development and homeostasis – lessons from studies of human disorders
Summary Studies of proliferative hemangiomas have led to the discovery that interactions of endothelial cells with extracellular matrix and/or Vascular Endothelial Growth Factor (VEGF)‐A stimulate the expression of VEGFR1, the VEGF decoy receptor, and suppress VEGF‐dependent VEGFR2 signalling by a mechanism that requires the matrix‐binding receptor Anthrax Toxin Receptor (ANTXR)1, VEGFR2, β1 integrin and the Nuclear Factor of Activated T cells (NFAT). In hemangioma endothelial cells, all these components are present, but are functionally compromised, so that the levels of VEGFR1 are extremely low and VEGFR2 signalli...
Source: International Journal of Experimental Pathology - August 31, 2016 Category: Pathology Authors: Bjorn R. Olsen, Agnes D. Berendsen, Tatiana Y. Besschetnova, Xuchen Duan, Kai Hu Tags: Review Article Source Type: research

Emphysema induced by elastase enhances acute inflammatory pulmonary response to intraperitoneal LPS in rats
In conclusion, the presence of emphysema induced by elastase increases the inflammatory response in the lungs to a systemic stimulus, represented in this model by the intraperitoneal injection of LPS. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: L ídia Maria Carneiro da Fonseca, Maycon Moura Reboredo, Leda Marília Fonseca Lucinda, Thaís Fernanda Fazza, Maria Aparecida Esteves Rabelo, Adenilson Souza Fonseca, Flavia Paoli, Bruno Valle Pinheiro Tags: Original Article Source Type: research

Vein graft disease in a knockout mouse model of hyperhomocysteinaemia
In conclusion, hyperhomocysteinaemic cystathionine‐beta‐synthase knockout mice can play an important role in the study of mechanisms of vein graft failure. But further in vitro and in vivo studies are necessary to answer the question whether or not homocysteine itself or a related metabolic factor is the key aetiologic agent for accelerated vein graft disease. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Christina Maria Steger, Tobias Mayr, Nikolaos Bonaros, Johannes Bonatti, Thomas Schachner Tags: Original Article Source Type: research

Hypermethylation of ATP ‐binding cassette B1 (ABCB1) multidrug resistance 1 (MDR1) is associated with cisplatin resistance in the A549 lung adenocarcinoma cell line
In conclusion, this in vitro and human tissue study of lung adenocarcinoma cells demonstrated that hypermethylation of the ABCB1 gene correlated with increased gene expression and was associated with the acquisition of resistance to the cisplatin analogue, DDP in human lung adenocarcinoma cells. Taken together, our study highlighted the connection between increased ABCB1 methylation level and upregulated expression of the gene in lung cancer. Moreover, the abnormally high expression of ABCB1 in A549 cells contributed to the development of the DDP resistance. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Angui Li, Jianfei Song, Qi Lai, Bangqing Liu, Haiyong Wang, Yinhui Xu, Xiaoyan Feng, Xiaolin Sun, Zhenzong Du Tags: Original Article Source Type: research

Inflammation, oxidative stress and apoptosis cascade implication in bisphenol A ‐induced liver fibrosis in male rats
Summary Bisphenol A (BPA) is a key monomer in the production of plastics. It has been shown to be hepatotoxic. Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of chronic exposure to BPA on the development of hepatic fibrosis in male rats and to determine the cross‐talk between the hepatic cytokine network, oxidative stress and apoptosis. For this purpose, 30 male Wistar albino rats were divided into three equal groups as follows: the first group was given no treatment (normal control gro...
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Sahar El ‐Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasan Tags: Original Article Source Type: research

The effect of combined inositol hexakisphosphate and inositol supplement in streptozotocin ‐induced type 2 diabetic rats
Summary Inositol hexakisphosphate (IP6) and inositol both regulate insulin secretion, but their combined use in the management of diabetes deserves investigation. The combined effects of IP6 and inositol supplementation were investigated in streptozotocin‐induced type 2 diabetic rats. The following groups of rats were studied for 8 weeks: non‐diabetic control, non‐diabetic high‐fat diet control, diabetic untreated, diabetic rats treated with the combination of IP6 and inositol (650 mg/kg bw) and diabetic rats treated with glibenclamide (10 mg/kg bw). High‐fat diet and streptozotocin were used to induce type 2 ...
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Shadae R. Foster, Felix O. Omoruyi, Juan Bustamante, Ruby L. A. Lindo, Lowell L. Dilworth Tags: Original Article Source Type: research

Imatinib accelerates progenitor cell ‐mediated liver regeneration in choline‐deficient ethionine‐supplemented diet‐fed mice
Summary Severe chronic hepatic injury can induce complex reparative processes. Ductular reaction and the appearance of small hepatocytes are standard components of this response, which is thought to have both adverse (e.g. fibrosis, carcinogenesis) and beneficial (regeneration) consequences. This complex tissue reaction is regulated by orchestrated cytokine action. We have investigated the influence of the tyrosine kinase inhibitor imatinib on a regenerative process. Ductular reaction was induced in mice by the widely used choline‐deficient ethionine‐supplemented diet (CDE). Test animals were treated daily with imatini...
Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Andr ás Rókusz, Edina Bugyik, Vanessza Szabó, Armanda Szücs, Sándor Paku, Péter Nagy, Katalin Dezső Tags: Original Article Source Type: research

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(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 25, 2016 Category: Pathology Tags: Issue Information Source Type: research

The role of heparan sulphate in development: the ectodermal story
Summary Heparan sulphate (HS) is ubiquitously expressed and is formed of repeating glucosamine and glucuronic/iduronic acid units which are generally highly sulphated. HS is found in tissues bound to proteins forming HS proteoglycans (HSPGs) which are present on the cell membrane or in the extracellular matrix. HSPGs influence a variety of biological processes by interacting with physiologically important proteins, such as morphogens, creating storage pools, generating morphogen gradients and directly mediating signalling pathways, thereby playing vital roles during development. This review discusses the vital role HS play...
Source: International Journal of Experimental Pathology - July 5, 2016 Category: Pathology Authors: Vivien Jane Coulson‐Thomas Tags: Review Article Source Type: research