International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - June 27, 2017 Category: Pathology Tags: Issue Information Source Type: research

Identification of DJ ‐1 as a contributor to multidrug resistance in human small‐cell lung cancer using proteomic analysis
Summary Proteomic approaches have been proven to provide an important tool in identifying drug resistance‐associated proteins. The aim of this study was to investigate the protein profiling of drug resistance‐related proteins in small‐cell lung cancer (SCLC) by proteomic analysis. The proteomic profiling was performed by two‐dimensional fluorescence difference gel electrophoresis (2D‐DIGE) coupled with MALDI‐TOF‐TOF of SCLC in the multidrug‐resistant cell line H69AR and its parental cell line H69. A total of 11 proteins were identified to be >2‐fold up‐or downregulated between the two cell lines. DJ�...
Source: International Journal of Experimental Pathology - June 5, 2017 Category: Pathology Authors: Hongyi Gao, Yuchun Niu, Man Li, Shun Fang, Linlang Guo Tags: Original Article Source Type: research

Specific knock ‐down of tissue non‐specific alkaline phosphatase mRNA levels inhibits intracellular lipid accumulation in 3T3‐L1 and HepG2 cells
Summary The use of non‐specific inhibitors of tissue non‐specific alkaline phosphatase (TNSALP) in pre‐adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre‐adipocytes. The purpose of this study was to use specific silencing of TNSALP mRNA, using short interfering (si) RNA, to investigate the role of TNSALP in intracellular lipid accumulation in 3T3‐L1 and HepG2 cells. Cellular activity of TNSALP was measured using an automated colorimetric assay, and intracellular lipid accumulation was determined using the lipi...
Source: International Journal of Experimental Pathology - June 1, 2017 Category: Pathology Authors: George Chirambo, Chantal van Niekerk, Nigel J. Crowther Tags: Original Article Source Type: research

Fibrillin microfibrils: structural tensometers of elastic tissues?
Summary Fibrillin microfibrils are indispensable structural elements of connective tissues in multicellular organisms from early metazoans to humans. They have an extensible periodic beaded organization, and support dynamic tissues such as ciliary zonules that suspend the lens. In tissues that express elastin, including blood vessels, skin and lungs, microfibrils support elastin deposition and shape the functional architecture of elastic fibres. The vital contribution of microfibrils to tissue form and function is underscored by the heritable fibrillinopathies, especially Marfan syndrome with severe elastic, ocular and ske...
Source: International Journal of Experimental Pathology - June 1, 2017 Category: Pathology Authors: Cay M. Kielty Tags: Review Article Source Type: research

Hepatocellular carcinoma in a mouse model fed a choline ‐deficient, L‐amino acid‐defined, high‐fat diet
Summary Hepatocellular carcinoma (HCC) is a common cancer worldwide and represents the outcome of the natural history of chronic liver disease. The growing rates of HCC may be partially attributable to increased numbers of people with non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH). However, details of the liver‐specific molecular mechanisms responsible for the NAFLD–NASH–HCC progression remain unclear, and mouse models that can be used to explore the exact factors that influence the progression of NAFLD/NASH to the more chronic stages of liver disease and subsequent HCC are not...
Source: International Journal of Experimental Pathology - June 1, 2017 Category: Pathology Authors: Ayae Ikawa ‐Yoshida, Saori Matsuo, Atsuhiko Kato, Yusuke Ohmori, Atsuko Higashida, Eiji Kaneko, Masahiko Matsumoto Tags: Original Article Source Type: research

Physical training improves visceral adipose tissue health by remodelling extracellular matrix in rats with estrogen absence: a gene expression analysis
This study investigated whether exercise training may be an alternative strategy to combat the effects promoted by estrogen decay through modulation in gene expression patterns in the extracellular matrix (ECM) of visceral adipose tissue of ovariectomized rats. Nulliparous rats (n = 40) were randomly distributed into four groups (n = 10/group): sham sedentary (Sh‐S), sham resistance training (Sh‐Rt), ovariectomized sedentary (Ovx‐S) and ovariectomized resistance training (Ovx‐Rt). The Sh‐S animals did not have any type of training. The body mass and food intake, ECM gene expression, gelatinase MMP‐2 activit...
Source: International Journal of Experimental Pathology - June 1, 2017 Category: Pathology Authors: Fernanda O. Duarte, Camila do Valle Gomes ‐Gatto, Jorge C. Oishi, Anderson Diogo de S. Lino, Uliana S. Stotzer, Maria Fernanda C. Rodrigues, Guilherme H. Gatti da Silva, Heloisa S. Selistre‐de‐Araújo Tags: Original Article Source Type: research

British Society for Matrix Biology Autumn 2016 Meeting: The Art of Communication – Signalling Cascades in Mechanotransduction
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - May 30, 2017 Category: Pathology Tags: BSMB Abstracts Source Type: research

Effects of exercise training on breast cancer metastasis in a rat model
Summary Exercise training is thought to play a protective role against cancer development and metastasis, either by reducing hormonal stimulation of hormone‐dependent cancers or by reducing the permeability of vascular walls towards invading metastatic cells. The purpose of this work was to evaluate the role of long‐term exercise training in the development and metastasis of breast cancer, in an immune‐competent 1‐methyl‐1‐nitrosourea (MNU) induced rat model. A single MNU dose was administered to Sprague‐Dawley rats at 50 days of age and the rats were subjected to exercise training on a treadmill at 20 m/mi...
Source: International Journal of Experimental Pathology - May 30, 2017 Category: Pathology Authors: Antonieta Alvarado, Rui M. Gil da Costa, Ana I. Faustino ‐Rocha, Rita Ferreira, Carlos Lopes, Paula A. Oliveira, Bruno Colaço Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - May 30, 2017 Category: Pathology Tags: Issue Information Source Type: research

Fell Muir Lecture: Collagen fibril formation in vitro and in vivo
Summary It is a great honour to be awarded the Fell Muir Prize for 2016 by the British Society of Matrix Biology. As recipient of the prize, I am taking the opportunity to write a minireview on collagen fibrillogenesis, which has been the focus of my research for 33 years. This is the process by which triple helical collagen molecules assemble into centimetre‐long fibrils in the extracellular matrix of animals. The fibrils appeared a billion years ago at the dawn of multicellular animal life as the primary scaffold for tissue morphogenesis. The fibrils occur in exquisite three‐dimensional architectures that match the ...
Source: International Journal of Experimental Pathology - May 16, 2017 Category: Pathology Authors: Karl E. Kadler Tags: Review Article Source Type: research

Evidence of bone marrow downregulation in brain ‐dead rats
In conclusion, data presented suggest that the downregulation of the bone marrow is triggered by brain death itself, and it is not related to changes in lymphocyte subsets, granulocyte adhesion molecules expression or apoptosis and necrosis. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - April 1, 2017 Category: Pathology Authors: Laura Menegat, Rafael Simas, Julia M. Caliman, Fernando L. Zanoni, Jacqueline F. Jacysyn, Luiz Fernando F. Silva, Primavera Borelli, Luiz Felipe P. Moreira, Paulina Sannomiya Tags: Original Article Source Type: research

Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates
This study evaluated the effects of the glucocorticoid corticosterone on the ventral prostate of the Mongolian gerbil. Male gerbils (Meriones unguiculatus) (n = 5) received intraperitoneal injections of saline or corticosterone in doses of 0.5 mg/kg/day and 1.5 mg/kg/day for 5 days; while some of the animals were killed immediately after the treatment, the others were killed 5 days after the treatment period. The data show that corticosterone influences the structure and functionality of this organ. This hormone has anti‐proliferative and anti‐apoptotic properties in the prostate. In addition, the frequencies of ...
Source: International Journal of Experimental Pathology - April 1, 2017 Category: Pathology Authors: Julia Quilles Antoniassi, Ricardo Alexandre Fochi, Rejane Maira G óes, Patricia Simone Leite Vilamaior, Sebastião Roberto Taboga Tags: Original Article Source Type: research

Abstracts: British Society for Matrix Biology “The Grey Area – Age and the Extracellular Matrix”
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - March 29, 2017 Category: Pathology Tags: BSMB Abstracts Source Type: research

Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis
This study aimed to investigate whether the control of inflammation by mefenamic acid translates into decreased joint lesions in experimental OA in rats. OA was induced by injecting 1 mg of monosodium iodoacetate (MIA) into the joints of rats. The animals were treated with mefenamic acid (50 mg/kg, daily, oral gavage) either pre‐MIA injection (preventive) or post‐MIA injection (therapeutic). Joint swelling and hyperalgesia were evaluated at baseline and 1, 3, 14 and 28 days after induction of OA. Intra‐articular lavage and kinetics of cell migration into the synovium were measured 3 and 28 days after OA induction...
Source: International Journal of Experimental Pathology - March 29, 2017 Category: Pathology Authors: Grazielle C. Aguiar, Celso M. Queiroz ‐Junior, Giovana L. Sitta, Flávio A. Amaral, Mauro M. Teixeira, Marcelo V. Caliari, Anderson J. Ferreira Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - March 29, 2017 Category: Pathology Tags: Issue Information Source Type: research