International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat
The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)‐, vasoactive intestinal polypeptide (VIP)‐ and glial fibrillary acidic protein (GFAP)‐immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneously treated from 3 to 10 days of age with 3.5 mg/g/day. Locomotor activity was evaluated at 90 days of age using ‘open‐field’ test, and the brains were processed for immunohistochemical studies. MSG exposure in...
Source: International Journal of Experimental Pathology - October 1, 2015 Category: Pathology Authors: Julio César Rojas‐Castañeda, Rosa María Vigueras‐Villaseñor, Margarita Chávez‐Saldaña, Patricia Rojas, Oscar Gutiérrez‐Pérez, Carolina Rojas, Marcela Arteaga‐Silva Tags: Original Article Source Type: research

Reduced AMPKα2 protein expression restores glucose‐induced insulin secretion in islets from calorie‐restricted rats
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP‐activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β‐cell function in islets from rats subjected to CR for 21 days. Eight‐week‐old male rats were distributed into a control (CTL) group that was fed an isocaloric diet ad libitum or a CR group that received 60% of the food consumed by the CTL group. From days 18–21, CTL and CR rats were treated with sense (CTLS and CRS) or antisense (CTLAS and CRAS) AMPKα2 oligonucleotides. Caloric restriction was associated with decrea...
Source: International Journal of Experimental Pathology - October 1, 2015 Category: Pathology Authors: Maria Esméria C. Amaral, Rosane A. Ribeiro, Emerielle C. Vanzela, Helena C. Barbosa‐Sampaio Tags: Original Article Source Type: research

Microarray Profiling analysis of long non‐coding RNAs expression in tendinopathy: identification for potential biomarkers and mechanisms
Summary The role of lncRNAs in pathologies of tendinopathy has not been researched so far, this study aims to identify the role and potent mechanism of lncRNAs in tendinopathy with a bioinformatic analysis. The gene profile of GSE26051 based on the platform of Affymetrix Human Genome U133B Array condensed was downloaded from Gene Expression Omnibus. A total of 46 specimens (including 23 normal samples and 23 tendinopathy specimens) were available. Compared with the control samples, differentially expressed genes (DEGs) of tendinopathy was identified the by packages in R. The selected DEGs were further analysed using bioinf...
Source: International Journal of Experimental Pathology - October 1, 2015 Category: Pathology Authors: Qiang Zhang, Heng'an Ge, Yuqing Jiang, Biao Cheng, Dong Zhou, Nanwei Xu Tags: Original Article Source Type: research

Quick benefits of interval training versus continuous training on bone: a dual‐energy X‐ray absorptiometry comparative study
Summary To delay age‐related bone loss, physical activity is recommended during growth. However, it is unknown whether interval training is more efficient than continuous training to increase bone mass both quickly and to a greater extent. The aim of this study was to compare the effects of a 10‐week interval training regime with a 14‐week continuous training regime on bone mineral density (BMD). Forty‐four male Wistar rats (8 weeks old) were separated into four groups: control for 10 weeks (C10), control for 14 weeks (C14), moderate interval training for 10 weeks (IT) and moderate continuous training for 14 w...
Source: International Journal of Experimental Pathology - October 1, 2015 Category: Pathology Authors: Arnaud Boudenot, Delphine B. Maurel, Stéphane Pallu, Isabelle Ingrand, Nathalie Boisseau, Christelle Jaffré, Hugues Portier Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - August 24, 2015 Category: Pathology Tags: Issue Information Source Type: research

Gestational hypermethioninaemia alters oxidative/nitrative status in skeletal muscle and biomarkers of muscular injury and inflammation in serum of rat offspring
In this study we evaluated oxidative/nitrative stress parameters (reactive oxygen species production, lipid peroxidation, sulfhydryl content, superoxide dismutase, catalase and nitrite levels), as well as total protein content in the gastrocnemius skeletal muscle of the offspring of rats that had been subjected to gestational hypermethioninaemia. The occurrence of muscular injury and inflammation was also measured by creatine kinase activity, levels of creatinine, urea and C‐reactive protein and the presence of cardiac troponin I in serum. Wistar female rats (70–90 days of age) received methionine (2.68 μmol/g body ...
Source: International Journal of Experimental Pathology - August 24, 2015 Category: Pathology Authors: Bruna M. Schweinberger, Elias Turcatel, André F. Rodrigues, Angela T. S. Wyse Tags: Original Article Source Type: research

Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods
In conclusion, the different doses of ND caused changes in the estrous cycle and ovarian tissue of rats, and recovery periods (30 and 60 days) were insufficient to completely restore the damage in the animals treated with the highest dose. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - August 1, 2015 Category: Pathology Authors: Vinícius Augusto Simão, Larissa Berloffa Belardin, Gabriel Adan Araújo Leite, Luiz Gustavo Almeida Chuffa, Isabel Cristina Cherici Camargo Tags: Original Article Source Type: research

Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
In this study, the effects of different doses of imidacloprid on learning and memory of infant and adult rats were evaluated, and the expressions of genes synthesizing proteins known to be associated with learning in brain tissues were also documented. 0.5, 2 and 8 mg/kg doses of imidacloprid were administered to newborn infant and adult Wistar albino rats by gavage. Their learning activities were evaluated, and the expression levels of the inotropic glutamate receptor GRIN1, synoptophysin, growth‐associated protein 43 and the muscarinic receptor M1 in hippocampus were determined by real‐time PCR method. Learning acti...
Source: International Journal of Experimental Pathology - August 1, 2015 Category: Pathology Authors: Murat Kara, Onder Yumrutas, Caner F. Demir, Hasan Huseyin Ozdemir, Ibrahim Bozgeyik, Salih Coskun, Ersen Eraslan, Ramazan Bal Tags: Original Article Source Type: research

Changes in calsequestrin, TNF‐α, TGF‐β and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles
In this study, we performed a comparative evaluation of the progression of dystrophy within muscles that are differently affected by dystrophy (diaphragm; DIA and quadriceps; QDR) or spared (intrinsic laryngeal muscles) using the mdx mice model of DMD. We assessed muscle levels of calsequestrin (calcium‐related protein), tumour necrosis factor (TNF‐α; pro‐inflammatory cytokine), tumour growth factor (TGF‐β; pro‐fibrotic factor) and MyoD (muscle proliferation) vs. histopathology at early (1 and 4 months of age) and late (9 months of age) stages of dystrophy. Fibrosis was the primary feature in the DIA of mdx m...
Source: International Journal of Experimental Pathology - August 1, 2015 Category: Pathology Authors: Juliana Barros Maranhão, Drielen Oliveira Moreira, Adriana Fogagnolo Maurício, Samara Camaçari Carvalho, Renato Ferretti, Juliano Alves Pereira, Humberto Santo Neto, Maria Julia Marques Tags: Original Article Source Type: research

The efficiency of Poly(ADP‐Ribose) Polymerase (PARP) cleavage on detection of apoptosis in an experimental model of testicular torsion
Summary The aim of this study was to evaluate the histopathological and apoptotic changes occurring in the rat ipsilateral and contralateral testes, after experimental spermatic cord torsion, and to explore and the role of poly(ADP‐ribose) polymerase (PARP) cleavage in testicular torsion–detorsion injury. A total of 37 Wistar albino rats were subjected to 720° unilateral spermatic cord torsion for 1, 2 and 4 h, followed by 4‐h reperfusion, or else to a sham operation (control group). Histology of the testicle was evaluated using haematoxylin–eosin (H&E) staining and Johnsen's scoring system. Germ cell apoptos...
Source: International Journal of Experimental Pathology - August 1, 2015 Category: Pathology Authors: Pınar Aslan Koşar, Hamdi Tuncer, Abdülhadi Cihangir Uğuz, Javier Espino Palma, Hakan Darıcı, İbrahim Onaran, Bilal Çiğ, Alim Koşar, Ana Beatriz Rodriguez Moratinos Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 28, 2015 Category: Pathology Tags: Issue Information Source Type: research

Nitrogen‐containing bisphosphonate therapy: assessment of the alveolar bone structure in rats – a blind randomized controlled trial
This study aimed to assess the effect of zoledronic acid exposure on structures of the alveolar bone of rats. The sample was composed of 42 male Wistar rats. Animals in the T1 and T2 groups received weekly doses of 0.2 mg/kg intraperitoneal zoledronic acid for 3 weeks, while animals in the T3 group received the same treatment for 8 weeks. The control groups C1, C2 and C3 received equivalent doses of saline. The first upper molars of Wistar rats in the C2, T2, C3 and T3 groups were extracted. Cone‐beam computerized tomography scans were performed, and the image density was analysed by grey levels. The presence and type...
Source: International Journal of Experimental Pathology - June 29, 2015 Category: Pathology Authors: Viviane N. Pacheco, Renan Langie, Adriana Etges, Deise Ponzoni, Edela Puricelli Tags: Original Article Source Type: research

miR‐7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1
Summary MicroRNAs (miRNAs) represent a class of small non‐coding RNAs and have been shown to play important roles in various biological processes including cell growth, differentiation and apoptosis by regulating the target genes. miR‐7 has been described not only as a tumour suppressor gene but also as an oncogene in human cancers. The aim of this study was to investigate the functional roles of miR‐7 in chemoresistance of SCLC and its underlying mechanism. By using a bioinformatic assay, we found that MRP1/ABCC1 was a potential target gene of miR‐7. Expression of miR‐7 and MRP1/ABCC1 was examined in 44 SCLC sam...
Source: International Journal of Experimental Pathology - June 24, 2015 Category: Pathology Authors: Huanxin Liu, Xiaoxia Wu, Jie Huang, Juan Peng, Linlang Guo Tags: Original Article Source Type: research

Oxidative and proteolysis‐related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction
The objective of this study was to investigate whether emphysema induced by elastase or papain triggers the same effects on skeletal muscle, related to oxidative stress and proteolysis, in hamsters. For this purpose, we evaluated pulmonary lesions, body weight, muscle loss, oxidative stress (thiobarbituric acid‐reactive substances, total and oxidized glutathiones, chemiluminescence stimulated by tert‐butyl hydroperoxide and carbonyl proteins), chymotrypsin‐like and calpain‐like proteolytic activities and muscle fibre cross‐sectional area in the gastrocnemius muscles of emphysemic hamsters. Two groups of animals r...
Source: International Journal of Experimental Pathology - June 22, 2015 Category: Pathology Authors: Cláudia R. Brunnquell, Nichelle A. Vieira, Laís R. Sábio, Felipe Sczepanski, Alessandra L. Cecchini, Rubens Cecchini, Flávia A. Guarnier Tags: Original Article Source Type: research

A novel technique for simultaneous whole‐body and multi‐organ decellularization: umbilical artery catheterization as a perfusion‐based method in a sheep foetus model
In this study, there have been unique responses to the single acellularization protocol in foetuses, which may reflect the homogeneity of tissues and organs in the developing foetal body. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - May 28, 2015 Category: Pathology Authors: Abdol‐Mohammad Kajbafzadeh, Reza Khorramirouz, Aram Akbarzadeh, Shabnam Sabetkish, Nastaran Sabetkish, Paria Saadat, Mona Tehrani Tags: Original Article Source Type: research