International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The protective properties of melatonin against aluminium‐induced neuronal injury
Summary Aluminium (Al) toxicity is closely linked to the pathogenesis of Alzheimer's disease (AD). This experimental study investigated the neuroprotective effect of melatonin (Mel; 10 mg/kg bwt) on aluminium chloride (AlCl3; 34 mg/kg bwt) induced neurotoxicity and oxidative stress in rats. Adult male albino Wistar rats were injected with AlCl3 for 7 days. The effect on brain structure, lipid peroxidation (LPO), nitric oxide (NO) levels, glutathione (GSH) content, antioxidant enzymes (SOD, CAT, GPx and GR), apoptotic proteins (Bax and Bcl‐2) and an apoptotic enzyme (caspase‐3) was investigated. No apparent changes o...
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Ebtesam M. Al‐Olayan, Manal F. El‐Khadragy, Ahmed E. Abdel Moneim Tags: Original Article Source Type: research

Joint meeting of British Societies for Matrix Biology and Developmental Biology ‘The musculoskeletal system; from development to disease’
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Tags: Abstracts Source Type: research

Effect of alpha lipoic acid co‐administration on structural and immunohistochemical changes in subcutaneous tissue of anterior abdominal wall of adult male albino rat in response to polypropylene mesh implantation
This study aimed to investigate the effect of alpha‐lipoic acid (ALA) co‐administration on structural and immunohistochemical (IHC) changes in the subcutaneous tissues of the anterior abdominal wall of the adult rat in response to polypropylene mesh implantation. Forty adult male albino rats were divided into: group I (control), group II (receiving ALA), group III (polypropylene mesh implantation) and group IV (mesh implantation + ALA co‐administration). After 4 weeks, subcutaneous tissue samples were prepared for light microscopy and IHC study of CD34 as a marker for angiogenesis. In groups I and II rats, positiv...
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Shireen A. Mazroa, Samar A. Asker, Waleed Asker, Mohamed Abd Ellatif Tags: Original Article Source Type: research

Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes
This study aimed to investigate whether maternal use of flaxseed oil has effects on pancreas morphology in the female offspring of diabetic mothers. Female Wistar rats (n = 12) were induced into diabetes by a high‐fat diet and low dose of streptozotocin. After confirmation of the diabetes, rats were mated, and once pregnancy was confirmed, they were allocated into three groups (n = 6): high‐fat group (HG); flaxseed oil group (FOG); and control group (CG) (non‐diabetic rats). At weaning, female offspring (n = 6/group) received standard chow diet. The animals were euthanized at 180 days. Pancreas was collected f...
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: André Manoel Correia‐Santos, Gabriela C. Vicente, Akemi Suzuki, Aline D. Pereira, Juliana S. Anjos, Kátia C. Lenzi‐Almeida, Gilson T. Boaventura Tags: Original Article Source Type: research

Oral administration of dextran sodium sulphate induces a caecum‐localized colitis in rabbits
We describe a reproducible and reliable rabbit model of DSS colitis. Localization of the inflammation in the caecum and its similarities to IBD make this model particularly suitable to study TSO therapy in vivo. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Irina Leonardi, Flora Nicholls, Kirstin Atrott, Alexandra Cee, Bernhard Tewes, Roland Greinwald, Gerhard Rogler, Isabelle Frey‐Wagner Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 29, 2014 Category: Pathology Tags: Issue Information Source Type: research

Fell‐Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour
Summary In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct members are present in mammals, one is present in invertebrates, including C. elegans that is such a powerful genetic model. The syndecans, therefore, have a long evolutionary history, indicative of important roles. However, these roles have been elusive. The knockout in the worm has a developmental neuronal phenotype, while knockouts of the syndecans in the mouse are mild and mostly limited to post‐natal rather than developmental effects. Moreover, their ass...
Source: International Journal of Experimental Pathology - December 26, 2014 Category: Pathology Authors: John R. Couchman, Sandeep Gopal, Hooi Ching Lim, Steffen Nørgaard, Hinke A.B. Multhaupt Tags: Review Article Source Type: research

Exogenous connexin43‐expressing autologous skeletal myoblasts ameliorate mechanical function and electrical activity of the rabbit heart after experimental infarction
Summary Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. The cells were characterized with muscle‐specific and myogenic markers. Cell transplantation was performed by injection of cell suspension (0.5 ml) containing approximately 6 million myoblasts into the infarction zone. The animals were divided into four groups: (i) no injection; (ii) sham injected; ...
Source: International Journal of Experimental Pathology - December 22, 2014 Category: Pathology Authors: Ieva Antanavičiūtė, Eglė Ereminienė, Vaidas Vysockas, Mindaugas Račkauskas, Vilius Skipskis, Kristina Rysevaitė, Rimantas Treinys, Rimantas Benetis, Jonas Jurevičius, Vytenis A. Skeberdis Tags: Original Article Source Type: research

Prostate hyperplasia caused by long‐term obesity is characterized by high deposition of extracellular matrix and increased content of MMP‐9 and VEGF
This study analysed the impact of long‐term obesity on rat prostate, focusing on stromal changes. Male adult Wistar rats were treated with high‐fat diet to induce obesity, while the control group received a balanced diet. After 30 weeks of feeding, the ventral prostate was analysed by immunohistochemistry for cell proliferation, smooth muscle α‐actin, vimentin, chondroitin sulphate and metalloproteinases (MMP‐2 and 9). The content of androgen receptor (AR), oestrogen receptors (ERs) and vascular endothelial growth factor (VEGF) was measured by Western blotting, and activity of catalase and Glutathione‐S‐Trans...
Source: International Journal of Experimental Pathology - December 21, 2014 Category: Pathology Authors: Silas Amâncio Silva, Marina Guimarães Gobbo, Maria Etelvina Pinto‐Fochi, Alex Rafacho, Sebastião Roberto Taboga, Eduardo Alves Almeida, Rejane Maira Góes, Daniele Lisboa Ribeiro Tags: Original Article Source Type: research

Induction and treatment of anergy in murine leprosy
Summary Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the genetic and immunological characteristics of the patient and on the characteristics of the leprosy bacillus. The malignant manifestations of lepromatous leprosy result from the mycobacterial‐specific anergy that develops in this form of the disease. Using murine leprosy as a model of anergy in this ...
Source: International Journal of Experimental Pathology - December 21, 2014 Category: Pathology Authors: Mario Juarez‐Ortega, Víctor G. Hernandez, Patricia Arce‐Paredes, Enrique B. Villanueva, Miguel Aguilar‐Santelises, Oscar Rojas‐Espinosa Tags: Original Article Source Type: research

Salivary gland homogenates from wild‐caught sand flies Lutzomyia flaviscutellata and Lutzomyia (Psychodopygus) complexus showed inhibitory effects on Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis infection in BALB/c mice
Summary During the natural transmission of Leishmania parasites, the infected sand fly female regurgitates promastigotes into the host's skin together with its saliva. It has been reported that vector saliva contains immunomodulatory molecules that facilitate the establishment of infection. Thus, the main objective of this study was to evaluate the specificity of Lutzomyia (Lu.) flaviscutellata and Lu. (Psychodopygus) complexus salivas on the infectivity of Leishmania (L.) (Leishmania) amazonensis and L. (Viannia) braziliensis, respectively. BALB/c mice were inoculated into the skin of hind footpad with L. (L.) amazonen...
Source: International Journal of Experimental Pathology - December 5, 2014 Category: Pathology Authors: Fernanda C. Francesquini, Fernando T. Silveira, Luiz Felipe D. Passero, Thaise Y. Tomokane, Ana Kely Carvalho, Carlos Eduardo P. Corbett, Márcia D. Laurenti Tags: Original Article Source Type: research

Increased aortic intimal proliferation due to MasR deletion in vitro
This study shows that the deletion of the MasR causes marked increase in the aortic intima:media ratio, which is not due to generalized cellular proliferation. These results provide a functional role for the MasR in atherogenesis. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 1, 2014 Category: Pathology Authors: Hiba Alsaadon, Peter Kruzliak, Arthur Smardencas, Alan Hayes, Michael Bader, Peter Angus, Chandana Herath, Anthony Zulli Tags: Original Article Source Type: research

Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin
Summary Transplantable murine melanomas are well‐established models for the study of experimental cancer therapies. The aim of this study was to analyse the behaviour of four different B16 murine melanoma cell sublines after inoculation in C57BL/6J host, more specifically skin‐targeted analysis, with respect to two parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non‐invasive and invasive determinations showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, succeeded by B16F10 and followed in a similar diminished manner...
Source: International Journal of Experimental Pathology - December 1, 2014 Category: Pathology Authors: Corina Danciu, Camelia Oprean, Dorina E. Coricovac, Cioca Andreea, Anca Cimpean, Heinfried Radeke, Codruta Soica, Cristina Dehelean Tags: Original Article Source Type: research

Double labelling of human umbilical cord mesenchymal stem cells with Gd‐DTPA and PKH26 and the influence on biological characteristics of hUCMSCs
Summary The aim of this study was to determine whether double labelling of human umbilical cord mesenchymal stem cells (hUCMSCs) with gadolinium‐diethylene triamine penta‐acetic acid (Gd‐DTPA) and PKH26 influences their biological characteristics. A tissue adherence technique was used to separate and purify the hUCMSCs and flow cytometry was performed to detect the surface markers expressed on them. Gd‐DTPA and PKH26 were used to label the stem cells and MRI and fluorescence microscopy were used to detect the double‐labelled hUCMSCs. A MTT assay was used to delineate the growth curve. Transmission electron micr...
Source: International Journal of Experimental Pathology - December 1, 2014 Category: Pathology Authors: Hanlin Shuai, Changzheng Shi, Jifa Lan, Danliang Chen, Xin Luo Tags: Original Article Source Type: research

Effect of strawberry (Fragaria × ananassa) leaves extract on diabetic nephropathy in rats
Summary Diabetic nephropathy is a clinical syndrome characterized by albuminuria, hypertension and progressive renal insufficiency. The aim of this study was to investigate the effect of strawberry (Fragaria × ananassa) leaves extract on diabetic nephropathy in rats. Streptozotocin (STZ) diabetic rats were orally treated with three doses (50, 100 and 200 mg/kg) of strawberry leaves extract for 30 days. Nephropathy biomarkers in plasma and kidney were examined at the end of the experiment. The three doses of strawberry leaves extract significantly decreased the levels of blood glucose, urea nitrogen, plasma creatinine,...
Source: International Journal of Experimental Pathology - December 1, 2014 Category: Pathology Authors: Doaa S. Ibrahim, Marwa A. E. Abd El‐Maksoud Tags: Original Article Source Type: research