International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Progesterone as a morphological regulatory factor of the male and female gerbil prostate
Summary Testosterone (T) and oestrogen are the main active steroid hormones in the male and female reproductive system respectively. In female rodents progesterone (P4), together with testosterone and oestrogen, has an essential role in the regulation of the oestrous cycle, which influences the prostate physiology through their oscillations. In this work we investigated how the male and female prostate gland of Mongolian gerbils responds to surgical castration at the start of puberty and what are the effects of T, oestradiol (E2) and P4 replacement, using both quantitative and qualitative methods. We also examined the loca...
Source: International Journal of Experimental Pathology - November 11, 2013 Category: Pathology Authors: Ricardo A. Fochi, Fernanda C. A. Santos, Rejane M. Goes, Sebastião R. Taboga Tags: Original Article Source Type: research

Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi
This study evaluated the influence of moderate physical exercise on the myenteric neurons in the colonic intestinal wall of mice that had been infected with Trypanosoma cruzi. Parasitology and immunological aspects of the mice were considered. Forty‐day‐old male Swiss mice were divided into four groups: Trained Infected (TI), Sedentary Infected (SI), Trained Control (TC), and Sedentary Control (SC). The TC and TI were subjected to a moderate physical exercise program on a treadmill for 8 weeks. Three days after finishing exercise, the TI and SI groups were inoculated with 1,300 blood trypomastigotes of the Y strain‐...
Source: International Journal of Experimental Pathology - November 1, 2013 Category: Pathology Authors: Neide M. Moreira, Franciele d. N. Santos, Max Jean d. O. Toledo, Solange M. F. d. Moraes, Eduardo J. d. A. Araujo, Debora d. M. G. Sant'Ana, Silvana M. d. Araujo Tags: Original Article Source Type: research

Neovascularization is prominent in the chronic inflammatory lesions of Sjögren's syndrome
Summary Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF‐A/VEGFR‐2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood vessel formation between the different grades of disease severity have not been reported. Therefore, experiments were performed to demonstrate angiogenesis during different phases of primary SS (pSS) and to define the relationship between the microvessel density (MVD), macrophage infiltration and ...
Source: International Journal of Experimental Pathology - November 1, 2013 Category: Pathology Authors: Margherita Sisto, Sabrina Lisi, Giuseppe Ingravallo, Dario Domenico Lofrumento, Massimo D'Amore, Domenico Ribatti Tags: Original Article Source Type: research

Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma
Summary A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4‐2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in melanoma carcinogenesis remains to be clarified. Here, we investigated the expression status of Nedd4L in human melanocytes, benign nevi and melanoma tissue specimens and subsequently attempted to determine the role of Nedd4L in melanoma cell growth. Immunohistochemical staining revealed that Nedd4L...
Source: International Journal of Experimental Pathology - October 31, 2013 Category: Pathology Authors: Yusuke Kito, Juncheng Bai, Naoe Goto, Hiroshi Okubo, Yoshihiro Adachi, Tomoko Nagayama, Tamotsu Takeuchi Tags: Original Article Source Type: research

Protective effect of γ‐tocopherol‐enriched diet on N‐methyl‐N‐nitrosourea‐induced epithelial dysplasia in rat ventral prostate
Summary Despite recent advances in understanding the biological basis of prostate cancer (PCa), the management of this disease remains a challenge. Chemoprotective agents have been used to protect against or eradicate prostate malignancies. Here, we investigated the protective effect of γ‐tocopherol on N‐methyl‐N‐nitrosourea (MNU)‐induced epithelial dysplasia in the rat ventral prostate (VP). Thirty‐two male Wistar rats were divided into four groups (n = 8): control (CT): healthy control animals fed a standard diet; control+γ‐tocopherol (CT+γT): healthy control animals without intervention fed a γ�...
Source: International Journal of Experimental Pathology - October 28, 2013 Category: Pathology Authors: Lucas D. Sanches, Sergio A. A. Santos, Jaqueline R. Carvalho, Gabriela D. M. Jeronimo, Wagner J. Favaro, Maria D. G. Reis, Sérgio L. Felisbino, Luis A. Justulin Tags: Original Article Source Type: research

Therapeutic reversal of chronic alcohol‐related steatohepatitis with the ceramide inhibitor myriocin
In conclusion, ceramide accumulation in liver mediates tissue injury, insulin resistance and lipotoxicity in ALD. Reducing hepatic ceramide levels can help restore the structural and functional integrity of the liver in chronic ALD due to amelioration of insulin resistance and ER stress. However, additional measures are needed to protect the liver from alcohol‐induced necroinflammatory responses vis‐à‐vis continued alcohol abuse. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - October 28, 2013 Category: Pathology Authors: Ming Tong, Lisa Longato, Teresa Ramirez, Valerie Zabala, Jack R. Wands, Suzanne M. Monte Tags: Original Article Source Type: research

Cytochrome P4503A activity affects the gender difference in the development of steroid‐induced osteonecrosis in rabbits
In conclusion, this study indicates that the gender difference in cytochrome P4503A activity may be one of the important factors for the development of steroid‐induced ON, possibly due to the effects of oestradiol. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - October 28, 2013 Category: Pathology Authors: Satoshi Ikemura, Takuaki Yamamoto, Goro Motomura, Ryosuke Yamaguchi, Garida Zhao, Kenyu Iwasaki, Yukihide Iwamoto Tags: Original Article Source Type: research

The effects of di(2‐ethylhexyl)phthalate on rat liver in relation to selenium status
This study was performed to determine the hepatotoxicity of di(2‐ethylhexyl)phthalate (DEHP) in relation to selenium status. In 3‐week‐old Sprague‐Dawley rats, selenium deficiency was induced by a ≤0.05 selenium mg/kg. A selenium supplementation group was given 1 mg selenium/kg diet for 5 weeks. Di(2‐ethylhexyl)phthalate‐treated groups received 1000 mg/kg dose by gavage during the last 10 days of the experiment. Histopathology, peroxisome proliferation, catalase (CAT) immunoreactivity and activity and apoptosis were assessed. Activities of antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), glutat...
Source: International Journal of Experimental Pathology - October 1, 2013 Category: Pathology Authors: Pınar Erkekoglu, Naciye D. Zeybek, Belma K. Giray, Walid Rachidi, Murat Kızılgün, Isabelle Hininger‐Favier, Alain Favier, Esin Asan, Filiz Hincal Tags: Original Article Source Type: research

Primary over‐expression of AβPP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK‐AβPP transgenic mouse
Summary The aim of this study is to determine whether primary over‐expression of AβPP in skeletal muscle results in the development of features of inclusion body myositis (IBM) in a new lineage of the MCK‐AβPP transgenic mouse. Quantitative histological, immunohistochemical and western blotting studies were performed on muscles from 3 to 18 month old transgenic and wild‐type C57BL6/SJL mice. Electron microscopy was also performed on muscle sections from selected animals. Although western blotting confirmed that there was over‐expression of full length AβPP in transgenic mouse muscles, deposition of amyloid‐β...
Source: International Journal of Experimental Pathology - October 1, 2013 Category: Pathology Authors: Yue‐Bei Luo, Russell D. Johnsen, Lisa Griffiths, Merrilee Needham, Victoria A. Fabian, Sue Fletcher, Steve D. Wilton, Frank L. Mastaglia Tags: Original Article Source Type: research

Epigenetics in Matrix Biology and Disease
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Tags: British Society for Matrix Biology ‐ Spring 2013 Meeting Report Source Type: research

Authors' Reply
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Man Yu, Qinghua Zou Tags: Letter to the Editor Source Type: research

Mitochondrial DNA depletion may also have a role in pathogenesis of osteosarcoma
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Bulent Kurt, Yasemin Gulcan‐Kurt, Tuncer Cayci, Emin O. Akgul Tags: Letter to the Editor Source Type: research

Long‐lasting morphofunctional remodelling of liver parenchyma and stroma after a single exposure to low and moderate doses of cadmium in rats
Summary Frequent exposure to cadmium (Cd) in low doses is common; however, the long‐lasting effects of this exposure are still poorly understood. Therefore in this study we have evaluated long‐lasting hepatic morphofunctional adaptations in rats exposed to low and moderate doses of Cd. Five experimental groups were tested: control (0.9% saline) and other four receiving single intraperitoneal doses of 0.67, 0.74, 0.86 and 1.1 mg of Cd/kg. The animals were killed after eight weeks and the following parameters were analysed: biometrics, oedema, Cd bio‐accumulation, collagen, glycogen, lipid droplets, superoxide dismut...
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Marli C. Cupertino, Kyvia L. C. Costa, Daiane C. M. Santos, Rômulo D. Novaes, Suellen S. Condessa, Ana C. Neves, Juraci A. Oliveira, Sérgio L. P. Matta Tags: Original Article Source Type: research

Cardiomyocyte ultrastructural damage in β‐thalassaemic mice
In this report cardiac pathology of β‐thalassaemic mice was evaluated by light and electron microscopy. The study was carried out in thalassaemic mice carrying human β‐thalassaemia mutation, IVSII‐654 (654), transgenic mice carrying human βE‐globin transgene insertion (E4), thalassaemic mice with human βE‐globin transgene insertion (654/E4) and homozygous thalassaemic mice rescued by the human βE‐globin transgene (R), which is generated by cross‐breeding between the 654 and E4 mice. Histology showed iron deposition in cardiac myocytes of 654 and R mice, but the ultrastructural damage was observed only in...
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Chanita Sanyear, Punnee Butthep, Ramaneeya Nithipongvanich, Pornpan Sirankapracha, Pranee Winichagoon, Suthat Fucharoen, Saovaros Svasti Tags: Original Article Source Type: research

Evaluation of autologous blood clot subsegmental pulmonary thromboembolism in minimally invasive experimental canine model
Summary The incidence and significance of subsegmental pulmonary (SSP) thromboembolism is currently under investigation. We aimed to evaluate the clinical and diagnostic features of SSP thromboembolism in an experimental canine model. Obstruction of pulmonary arterial branches was induced in three beagle dogs by intravenous injection of a barium‐coated autologous blood clot (size, approximately 1.7 × 5 mm). The clinical signs, haemodynamic changes (blood pressure, electrocardiogram, echocardiography), coagulation (aPTT, PT, FDPs and D‐dimer test) and cytokine variations (TNF‐a, IL‐4, IL‐6, and IL‐10) were e...
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Min‐Hee Kang, Hee‐Myung Park Tags: Original Article Source Type: research