International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mild diabetes: long ‐term effects on gastric motility evaluated in rats
In conclusion, despite increased insulin levels over time, constant levels of moderate hyperglycaemia are also related to abnormal gastric motility and impairment of gastric function. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Andrieli T. Hauschildt, Luciana A. Cor á, Gustavo T. Volpato, Yuri K. Sinzato, Débora C. Damasceno, Madileine F. Américo Tags: Original Article Source Type: research

Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for NF ‐κB activation in the Barrett metaplasia–dysplasia–adenocarcinoma sequence
Summary Non‐dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory response triggered through prolonged gastro‐oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. NF‐κB activation as a result of the inflammatory response has been shown in NDBE, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for NF‐κB activation along the oesophageal metaplasia–dysplasia–adenocarcinoma sequence. Survivin is an NF‐κB‐inducible anti�...
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Ignazio Puccio, Saif Khan, Adil Butt, David Graham, Vinay Sehgal, Dominic Patel, Marco Novelli, Laurence B. Lovat, Manuel Rodriguez ‐Justo, Rifat A. Hamoudi Tags: Original Article Source Type: research

Treatment with low doses of aspirin during chronic phase of experimental Chagas ’ disease increases oesophageal nitrergic neuronal subpopulation in mice
Summary Patients with Chagas’ disease may develop dysfunctions of oesophageal and colonic motility resulting from the degeneration or loss of the myenteric neurons of the enteric nervous system. Studies have shown that the use of aspirin, also known as acetylsalicylic acid (ASA), influences the pathogenesis of the disease. However, this remains controversial. The aim of this study was to evaluate the consequences of treatment with low doses of aspirin during the chronic phase of Chagas’ disease on oesophageal function. Twenty male Swiss mice, 60 days of age, were used. The animals were infected with Y strain of Trypan...
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Cristina Lorena Massocatto, Neide Martins Moreira, Eliane Muniz, Silvana Marques de Ara újo, Phileno Pinge‐filho, Robson Marcelo Rossi, Eduardo José Almeida Araújo, Débora Mello Gonçales Sant'ana Tags: Original Article Source Type: research

Promoter hypermethylation of SOX11 correlates with adverse clinicopathological features of human prostate cancer
Summary Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. SOX11 has been recently recognized as a potential tumour suppressor that is downregulated in prostate cancer. We hypothesized that hypermethylation may be responsible for SOX11 silencing in human prostate cancer. The aim of the study was to investigate SOX11 promoter methylation in prostate adenocarcinoma by comparing it with benign prostati...
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Apiwat Pugongchai, Andrey Bychkov, Pichet Sampatanukul Tags: Original Article Source Type: research

Histopathological and immunohistochemical characterization of Burkholderia pseudomallei lesions in an acute model of infection with BALB/c mice
Summary Organ tissue damage is a key contributor to host morbidity and mortality following infection with microbial agents. Severe immune responses, excessive cellular recruitment and necrosis of cells all play a role in disease pathology. Understanding the pathogenesis of disease can aid in identifying potential new therapeutic targets or simply act as a diagnostic tool. Burkholderia pseudomallei is a Gram‐negative bacterium that can cause acute and chronic diseases. The BALB/c mouse has been shown to be highly susceptible to aerosol challenge with B. pseudomallei and hence acts as a good model to study the acute and p...
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Waldo Luis Garc ía‐Jiménez, Francisco J. Salguero, Riccardo V. D'Elia Tags: Original Article Source Type: research

Resveratrol attenuates reproductive alterations in type 1 diabetes ‐induced rats
Summary The progression of diabetes mellitus leads to several complications including overproduction of reactive oxygen species and reproductive alterations. As resveratrol (RES) is a powerful anti‐oxidant and an anti‐apoptotic compound, we hypothesized that side effects of type‐1 diabetes (DM1) on male reproduction could be reduced by the RES treatment. Eighty‐four prepubertal male rats were distributed into seven groups: sham‐control (SC), RES‐treated (R), resveratrol‐vehicle‐treated (RV), diabetic (D), diabetic‐insulin‐treated (DI), diabetic‐RES‐treated (DR), diabetic‐insulin and RES‐treated ...
Source: International Journal of Experimental Pathology - October 1, 2017 Category: Pathology Authors: Joana Nogu ères Simas, Talita Biude Mendes, Camila Cicconi Paccola, Vanessa Vendramini, Sandra Maria Miraglia Tags: Original Article Source Type: research

Fell ‐Muir Lecture: Fibrillin microfibrils: structural tensometers of elastic tissues?
Summary Fibrillin microfibrils are indispensable structural elements of connective tissues in multicellular organisms from early metazoans to humans. They have an extensible periodic beaded organization, and support dynamic tissues such as ciliary zonules that suspend the lens. In tissues that express elastin, including blood vessels, skin and lungs, microfibrils support elastin deposition and shape the functional architecture of elastic fibres. The vital contribution of microfibrils to tissue form and function is underscored by the heritable fibrillinopathies, especially Marfan syndrome with severe elastic, ocular and ske...
Source: International Journal of Experimental Pathology - September 14, 2017 Category: Pathology Authors: Cay M. Kielty Tags: Review Article Source Type: research

Influence of indigenous microbiota on experimental toxoplasmosis in conventional and germ ‐free mice
In this study, we assessed the role of indigenous microorganisms in disease development utilizing a murine toxoplasmosis model, which includes conventional (CV) and GF NIH Swiss mice. CV and GF mice orally inoculated with T. gondii had similar survival curves. However, disease developed differently in the two animal groups. In CV mice, intestinal permeability increased and levels of intestinal pro‐inflammatory cytokines were altered. In GF animals, there were discrete epithelial degenerative changes and mucosal oedema, but the liver and lungs displayed significant lesions. We conclude that, despite similar survival curv...
Source: International Journal of Experimental Pathology - September 11, 2017 Category: Pathology Authors: Bruna B. Nascimento, Christiane T. Cartelle, Maria de L. Noviello, Breno V. Pinheiro, Ricardo W. Almeida Vitor, Danielle da G. Souza, Simone Vasconcelos Generoso, Valbert N. Cardoso, Flaviano dos S. Martins, Jacques R. Nicoli, Rosa M. E. Arantes Tags: Original Article Source Type: research

British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell ‐extracellular matrix communication
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - August 28, 2017 Category: Pathology Tags: BSMB Abstracts Source Type: research

Histological, morphometric, protein and gene expression analyses of rat retinas with ischaemia –reperfusion injury model treated with sildenafil citrate
SummaryThe aim of this study was to better understand the role of apoptosis in a retinal ischaemia–reperfusion injury model and to determine whether sildenafil citrate treatment can prevent retinal cell apoptosis. Thirty‐six rats were divided into a control group (n = 6) and two experimentally induced ischaemia–reperfusion groups (7 and 21 days; n = 15 per group). The induced ischaemia–reperfusion groups were treated with sildenafil for 7 and 21 days (n = 10 per group), and 10 animals were treated with a placebo for the same period (n = 5 per group). Paracentesis of the anterior chamber was performed with...
Source: International Journal of Experimental Pathology - August 28, 2017 Category: Pathology Authors: Diogo S. Zanoni, Germana A. Da Silva, Raaya Ezra ‐Elia, Márcio Carvalho, Juliany G. Quitzan, Ron Ofri, José L. Laus, Renee Laufer‐Amorim Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - August 28, 2017 Category: Pathology Tags: Issue Information Source Type: research

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice
Summary Sepsis is associated with high mortality. Both critically ill humans and animal models of sepsis exhibit changes in their glucose homeostasis, that is, hypoglycaemia, with the progression of infection. However, the relationship between basal glycaemia, glucose tolerance and insulin sensitivity is not well understood. Thus, we aimed to evaluate this glucose homeostasis triad at the late stage of sepsis (24 h after surgery) in male Swiss mice subjected to lethal and sublethal sepsis by the caecal ligation and puncture (CLP) model. The percentage of survival 24 h after CLP procedure in the Lethal and Sublethal group...
Source: International Journal of Experimental Pathology - August 1, 2017 Category: Pathology Authors: Francielle B. D. Ferreira, Cristiane Santos, Maciel A. Bruxel, Everson A. Nunes, Fernando Spiller, Alex Rafacho Tags: Original Article Source Type: research

Diets rich in saturated fat and fructose induce anxiety and depression ‐like behaviours in the rat: is there a role for lipid peroxidation?
Summary Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high‐fat diet (HF) and rats fed high‐fat and high‐fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water. Behavioural and biochemical parameters were determined. Anxiety was measured by t...
Source: International Journal of Experimental Pathology - August 1, 2017 Category: Pathology Authors: Silvia Gancheva, Bistra Galunska, Maria Zhelyazkova ‐Savova Tags: Original Article Source Type: research

Carnosine decreased oxidation and glycation products in serum and liver of high ‐fat diet and low‐dose streptozotocin‐induced diabetic rats
Summary High‐fat diet (HFD) and low‐dose streptozotocin (STZ)‐treated rats provide useful animal model for type II diabetes mellitus. Oxidative stress and advanced glycation end products (AGEs) play a role in the development of diabetic complications. Carnosine (CAR) has anti‐oxidant and anti‐glycating properties. We investigated the effects of CAR on oxidation and glycation products in HFD+STZ rats. Rats were fed with HFD (60% of total calories from fat) for 4 weeks, and then a single dose of STZ (40 mg/kg; i.p.) was applied. Rats with blood glucose levels above 200 mg/dl were fed with HFD until the end of th...
Source: International Journal of Experimental Pathology - August 1, 2017 Category: Pathology Authors: Abdurrahman Fatih Ayd ın, İlknur Bingül, Canan Küçükgergin, Işın Doğan‐Ekici, Semra Doğru Abbasoğlu, Müjdat Uysal Tags: Original Article Source Type: research

Androgen and oestrogen receptors as potential prognostic markers for patients with ductal carcinoma in  situ treated with surgery and radiotherapy
Summary Ductal carcinoma in situ (DCIS) is a heterogeneous disease that has been investigated less extensively than invasive breast cancer. Women with DCIS are mainly treated with conservative surgery almost exclusively followed by radiotherapy. However, as radiation treatment is not always effective, the search for biomarkers capable of identifying DCIS lesions that could progress to invasive cancer is ongoing. Although conventional biomarkers have been thoroughly studied in invasive tumours, little is known about the role played by androgen receptor (AR), widely expressed in DCIS. A series of 42 DCIS patients treated wi...
Source: International Journal of Experimental Pathology - August 1, 2017 Category: Pathology Authors: Sara Ravaioli, Maria Maddalena Tumedei, Flavia Foca, Roberta Maltoni, Andrea Rocca, Ilaria Massa, Elisabetta Pietri, Sara Bravaccini Tags: Original Article Source Type: research