International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes
Summary Mouse‐adapted transmissible spongiform encephalopathy (TSE) strains are routinely distinguished based on reproducible disease characteristics in a given mouse line following inoculation via a consistent route. We investigated whether different administration routes (oral, intragastric (i.g.) and intracerebral (i.c.)) can alter the disease characteristics in IM mice after serial dilution of a stabilized mouse‐adapted bovine spongiform encephalopathy (BSE) strain (301V). In addition, the infectivity of distal ileum and mesenteric lymph nodes (ln) sampled at three time points (35 days postinoculation (dpi), 70 d...
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Christopher M. Vickery, Katy E. Beck, Marion M. Simmons, Stephen A. C. Hawkins, John Spiropoulos Tags: Original Article Source Type: research

Experimental rat model for alcohol‐induced osteonecrosis of the femoral head
Summary Alcohol‐induced osteonecrosis of the femoral head (ONFH) is observed in alcohol abusers and patients with alcoholic fatty liver disease. It has been reported that Toll‐like receptor 4 (TLR4) signalling plays a crucial role in the pathogenesis of alcoholic fatty liver disease. We previously reported a corticosteroid‐induced ONFH rat model, and suggested that TLR4 signalling contributes to the pathogenesis of ONFH. Thus, it is thought that the pathogenesis of alcohol‐induced ONFH is probably similar to that of corticosteroid‐induced ONFH. The aim of this study was to develop a new animal model for alcohol�...
Source: International Journal of Experimental Pathology - September 10, 2013 Category: Pathology Authors: Shunichiro Okazaki, Satoshi Nagoya, Kenji Tateda, Ryuichi Katada, Keisuke Mizuo, Satoshi Watanabe, Toshihiko Yamashita, Hiroshi Matsumoto Tags: Original Article Source Type: research

Implications of combined ovariectomy and glucocorticoid (dexamethasone) treatment on mineral, microarchitectural, biomechanical and matrix properties of rat bone
Summary Osteoporosis is one of the deleterious side effects of long‐term glucocorticoid therapy. Since the condition is particularly aggressive in postmenopausal women who are on steroid therapy, in this study we have attempted to analyse the combined effect of glucocorticoid (dexamethasone) treatment and cessation of oestrogen on rat bone. The dual aim was to generate osteoporotic bone status in a short time scale and to characterise the combination of glucocorticoid–postmenopausal osteoporotic conditions. Sprague Dawley rats (N = 42) were grouped randomly into three groups: untreated control, sham‐operated and ov...
Source: International Journal of Experimental Pathology - September 2, 2013 Category: Pathology Authors: Parameswari Govindarajan, Thaqif Khassawna, Marian Kampschulte, Wolfgang Böcker, Britta Huerter, Lutz Dürselen, Miriam Faulenbach, Christian Heiss Tags: Original Article Source Type: research

Restoration of the normal Clara cell phenotype after chronic allergic inflammation
This study highlights the role of epithelial cells in lung injuries and their contribution to anti‐inflammatory therapies. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - September 2, 2013 Category: Pathology Authors: Felix D. Roth, Amado A. Quintar, Carolina Leimgruber, Luciana García, Elisa M. Uribe Echevarría, Alicia I. Torres, Cristina A. Maldonado Tags: Original Article Source Type: research

Amphiphilic suramin dissolves Matrigel, causing an ‘inhibition’ artefact within in vitro angiogenesis assays
Summary The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two common components of these assays were noted by our group to have an unexpected and previously unreported interaction. Suramin is a commercially available compound, commonly used as a positive control for in vitro angiogenic inhibition assays. Matrigel is a popular extracellular substrate that supports a...
Source: International Journal of Experimental Pathology - September 2, 2013 Category: Pathology Authors: Natalie L. Prigozhina, Andrew J. Heisel, Jordan R. Seldeen, Nicholas D. P. Cosford, Jeffrey H. Price Tags: Original Article Source Type: research

Endothelial nitric oxide synthase gene polymorphisms and prostate cancer risk in Serbian population
This study aimed to evaluate the association of NOS3 gene polymorphisms (−786T>C, −764A>G, −714G>T, −690C>T, −649G>A and 894G>T) with PCa risk and progression. 150 patients with PCa, 150 patients with BPH and 100 age‐matched healthy controls were recruited in this study. Genotyping of promoter polymorphisms was performed by bi‐directional DNA sequencing, and for 894G>T by RFLP analysis. There was no significant association between the alleles and genotypes of these genetic variants and PCa risk. For −786T>C polymorphism, we found that C allele is associated with absence of metastases...
Source: International Journal of Experimental Pathology - August 1, 2013 Category: Pathology Authors: Ana Branković, Goran Brajušković, Zorana Nikolić, Vinka Vukotić, Snežana Cerović, Dušanka Savić‐Pavićević, Stanka Romac Tags: Original Article Source Type: research

Tendinopathy – from basic science to treatment
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 9, 2013 Category: Pathology Tags: British Society for Matric Biology Special Meeting (Autumn 2012) Report and Abstracts Source Type: research

Synthetic and degradable patches: an emerging solution for rotator cuff repair
Summary The use of rotator cuff augmentation has increased dramatically over the last 10 years in response to the high rate of failure observed after non‐augmented surgery. However, although augmentations have been shown to reduce shoulder pain, there is no consensus or clear guideline as to what is the safest or most efficacious material. Current augmentations, either available commercially or in development, can be classified into three categories: non‐degradable structures, extra cellular matrix (ECM)‐based patches and degradable synthetic scaffolds. Non‐degradable structures have excellent mechanical propertie...
Source: International Journal of Experimental Pathology - July 9, 2013 Category: Pathology Authors: Osnat Hakimi, Pierre‐Alexis Mouthuy, Andrew Carr Tags: Review Article Source Type: research

Fatigue loading of tendon
This article aims to review these models and our current understanding of tendon fatigue damage. We review the strengths and limitations of different methodologies for characterizing tendon fatigue, considering in vitro methods that adopt both viable and non‐viable samples, as well as the range of different in vivo approaches. By comparing data across model systems, we review the current understanding of fatigue damage development. Additionally, we compare these findings with data from tendinopathic tissue biopsies to provide some insights into how these models may relate to the aetiology of tendinopathy. Fatigue‐induc...
Source: International Journal of Experimental Pathology - July 9, 2013 Category: Pathology Authors: Jennifer H. Shepherd, Hazel R. C. Screen Tags: Review Article Source Type: research

Continuum model of tendon pathology – where are we now?
Summary Chronic tendon pathology is a common and often disabling condition, the causes of which remain poorly understood. The continuum model of tendon pathology was proposed to provide a model for the staging of tendon pathology and to assist clinicians in managing this often complex condition (Br. J. Sports Med., 43, 2009, 409). The model presents clinical, histological and imaging evidence for the progression of tendon pathology as a three‐stage continuum: reactive tendinopathy, tendon disrepair and degenerative tendinopathy. It also provides clinical information to assist in identifying the stage of pathology, in add...
Source: International Journal of Experimental Pathology - July 9, 2013 Category: Pathology Authors: Karen McCreesh, Jeremy Lewis Tags: Review Article Source Type: research

Foreword
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - July 9, 2013 Category: Pathology Tags: Foreword Source Type: research

Musculoskeletal regeneration and its implications for the treatment of tendinopathy
Summary Tendinopathies are common muskoloskeletal injuries that lead to pain and disability. Development and pathogenesis of tendinopathy is attributed to progressive pathological changes to the structure, function, and biology of tendon. The nature of this disease state, whether acquired by acute or chronic injury, is being actively investigated. Scarring, disorganized tissue, and loss of function characterize adult tendon healing. Recent work from animal models has begun to reveal the potential for adult mammalian tendon regeneration, the replacement of diseased with innate tissue. This review discusses what is known abo...
Source: International Journal of Experimental Pathology - June 17, 2013 Category: Pathology Authors: Jedd B. Sereysky, Evan L. Flatow, Nelly Andarawis‐Puri Tags: Review Article Source Type: research

Mitochondrial DNA depletion may also have a role in pathogenesis of osteosarcoma
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - June 17, 2013 Category: Pathology Authors: Bulent Kurt, Yasemin Gulcan‐Kurt, Tuncer Cayci, Emin Ozgur Akgul Tags: Letter to the Editor Source Type: research

Authors' Reply
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - June 17, 2013 Category: Pathology Authors: Man Yu, Qinghua Zou Tags: Letter to the Editor Source Type: research

Mitochondrial DNA depletion may also have a role in pathogenesis of osteosarcoma
International Journal of Experimental Pathology, EarlyView. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - June 17, 2013 Category: Pathology Source Type: research