International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - May 28, 2015 Category: Pathology Tags: Issue Information Source Type: research

Application of talcum powder, trichloroacetic acid and silver nitrate in female rats for non‐surgical sterilization: evaluation of the apoptotic pathway mRNA and miRNA genes
This study demonstrates the expression levels of antioxidant, apoptotic and anti‐apoptotic genes after administration of talc powder, TCA and silver nitrate for non‐surgical sterilization in female rat models. The expression changes of some microRNAs (miR‐15b, miR‐21, miR‐34a and miR‐98) that play key roles in apoptosis pathway were also included. All expression analyses were evaluated with real‐time PCR. The expression levels of all genes appeared to be upregulated in the talcum powder group, but the results were not statistically significant. Increased expression of Gsr and Sod1 genes was statistically sign...
Source: International Journal of Experimental Pathology - April 17, 2015 Category: Pathology Authors: Onder Yumrutas, Murat Kara, Remzi Atilgan, Salih Burcin Kavak, Ibrahim Bozgeyik, Ekrem Sapmaz Tags: Original Article Source Type: research

Fell‐Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra
Summary Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens, chemokines), membrane receptors and cell adhesion proteins such as fibronectin, fibrillin and various types of collagen. The protein‐binding properties of HS, together with its strategic positioning in the pericellular domain, are indicative of key roles in mediating the flow of regulatory signals ...
Source: International Journal of Experimental Pathology - April 1, 2015 Category: Pathology Authors: John Gallagher Tags: Original Article Source Type: research

Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin
Summary Simvastatin can modulate lipid and bone metabolism. However, information related to the interaction between diet and simvastatin on bone structure and biomechanics is scarce. Thus, this study evaluated the effects of simvastatin on femoral biomechanics and cortical/trabecular bone structure in wild‐type mice nourished with a hyperlipidic diet. Three‐month‐old male wild‐type mice (C57BL6 strain) were divided into four groups: (1) group W, nourished with a standard diet; (2) group WH, fed a hyperlipidic diet; (3) group WS, nourished with a standard diet plus oral simvastatin (20 mg/kg/day); and (4) group WHS...
Source: International Journal of Experimental Pathology - April 1, 2015 Category: Pathology Authors: Evelise Aline Soares, Rômulo Dias Novaes, Wilson Romero Nakagaki, Geraldo José Medeiros Fernandes, José Antônio Dias Garcia, José Angelo Camilli Tags: Original Article Source Type: research

Nitrogen‐containing bisphosphonate therapy: assessment of the alveolar bone structure in mice – a blind randomized controlled trial
This study aimed to assess the effect of zoledronic acid exposure on structures of the alveolar bone of rats. The sample was composed of 42 male Wistar rats. Animals in the T1 and T2 groups received weekly doses of 0.2 mg/kg intraperitoneal zoledronic acid for 3 weeks, while animals in the T3 group received the same treatment for 8 weeks. The control groups C1, C2 and C3 received equivalent doses of saline. The first upper molars of Wistar rats in the C2, T2, C3 and T3 groups were extracted. Cone‐beam computerized tomography scans were performed, and the image density was analysed by grey levels. The presence and type...
Source: International Journal of Experimental Pathology - April 1, 2015 Category: Pathology Authors: Viviane N. Pacheco, Renan Langie, Adriana Etges, Deise Ponzoni, Edela Puricelli Tags: Original Article Source Type: research

Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma
In this study, we aimed to identify the expression and potential role of cortactin and HDAC6 in PfCa. Therefore, 16 PfCa specimens containing 48 foci with distinctive lesions were collected to identify the status of cortactin and HDAC6 by immunohistochemistry. Their correlation between clinicopathological characteristics and prognostic values were further analysed. The effect of cortactin and HDAC6 on prostate cancer cell migration and invasion was then evaluated in IA8 cells. The results showed that expression of cortactin and HDAC6 was significantly higher in PfCa foci, compared to that of high‐grade prostatic intraepi...
Source: International Journal of Experimental Pathology - April 1, 2015 Category: Pathology Authors: Huilian Hou, Le Zhao, Wei Chen, Jing Li, Qinqin Zuo, Guanjun Zhang, Xuebin Zhang, Xu Li Tags: Original Article Source Type: research

Prepubertal exposure to bisphenol‐A induces ERα upregulation and hyperplasia in adult gerbil female prostate
Summary Prostate physiology is highly dependent on oestrogenic and androgenic homeostasis. Interferences in this equilibrium, especially in early periods of life, may disrupt the prostate and increase the susceptibility to the development of diseases with ageing. Taking this into account, and considering the increase of environmental chemicals with endocrine‐disrupting potential such as bisphenol‐A (BPA), this study aimed to evaluate the prostates of adult female gerbils exposed to BPA and BPA plus testosterone from pubertal to adult periods. Morphological, stereological and chemical analyses revealed that long‐term ...
Source: International Journal of Experimental Pathology - April 1, 2015 Category: Pathology Authors: Mônica S. Campos, André L. V. Galvão, Daniel A. O. Rodríguez, Manoel F. Biancardi, Mara R. Marques, Patrícia S. L. Vilamaior, Fernanda C. A. Santos, Sebastião R. Taboga Tags: Original Article Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 25, 2015 Category: Pathology Tags: Issue Information Source Type: research

CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation
In conclusion, expression of CYP3A isoforms is noted in Ewing's sarcoma family tumours and high CYP3A4 expression may be associated with metastasis. Additional studies are needed to further investigate the role of CYP3A4 in the prognosis of these tumours. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 9, 2015 Category: Pathology Authors: Zia Hamid, Graeme I. Murray, Carrie A. Vyhlidal, J. Steven Leeder, Ahmed E. Anwar, Marilyn M. Bui, Atif A. Ahmed Tags: Original Article Source Type: research

Effect of different fixative solutions on eyes with experimental proliferative vitreoretinopathy
In conclusion, a mixture of buffered formaldehyde 1% and glutaraldehyde 1.25% combined with standardized scleral incision resulted in consistent pathological changes. A reliable PVR model is a condition sine qua non to evaluate antifibrotic treatment strategies. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 9, 2015 Category: Pathology Authors: Khaled Nassar, Julia Lüke, Matthias Lüke, Mahmoud Kamal, Mahmoud M. Soliman, Salvatore Grisanti, Swaantje Grisanti Tags: Original Article Source Type: research

Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats
Summary The aim of this study was to determine the effects of previous administration of metyrapone (met) on the acute lung injury (ALI) induced by caecal ligation and puncture (CLP) and to explore met's relationship with endogenous glucocorticoids (GCs) as measured by inflammatory, oxidative and functional parameters. One hundred and thirty‐five Wistar rats were divided into three main groups: Control (Naïve), Sham and CLP. The animals received pretreatment one hour before surgery. The Naïve group did not undergo any procedure or pretreatment. The Sham group only had the caecum exposed and was pretreated with saline. ...
Source: International Journal of Experimental Pathology - February 9, 2015 Category: Pathology Authors: Erika K. Incerpi, Luiz M. Oliveira, Elisângela M. Pereira, Roseli Soncini Tags: Original Article Source Type: research

Effect of strawberry (Fragaria × ananassa) leaf extract on diabetic nephropathy in rats
Summary Diabetic nephropathy is a clinical syndrome characterized by albuminuria, hypertension and progressive renal insufficiency. The aim of this study was to investigate the effect of strawberry (Fragaria × ananassa) leaf extract on diabetic nephropathy in rats. Streptozotocin (STZ) diabetic rats were orally treated with three doses (50, 100 and 200 mg/kg) of strawberry leaf extract for 30 days. Nephropathy biomarkers in plasma and kidney were examined at the end of the experiment. The three doses of strawberry leaf extract significantly decreased the levels of blood glucose, urea nitrogen, plasma creatinine, kidne...
Source: International Journal of Experimental Pathology - February 3, 2015 Category: Pathology Authors: Doaa S. Ibrahim, Marwa A. E. Abd El‐Maksoud Tags: Original Article Source Type: research

Vasoactive intestinal peptide suppresses macrophage‐mediated inflammation by downregulating interleukin‐17A expression via PKA‐ and PKC‐dependent pathways
Summary Interleukin (IL)‐17A is a pro‐inflammatory cytokine that markedly enhances inflammatory responses in the lungs by recruiting neutrophils and interacting with other pro‐inflammatory mediators. Reducing the expression of IL‐17A could attenuate inflammation in the lungs. However, whether VIP exerts its anti‐inflammatory effects by regulating the expression of IL‐17A has remained unclear. Here, we show that there is a remarkable increase of IL‐17A in bronchoalveolar lavage fluid (BALF) and lung tissue of mice with acute lung injury (ALI). Moreover, lipopolysaccharides (LPS) stimulated elevated expression...
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Wen‐Zhuo Ran, Liang Dong, Chun‐Yan Tang, Yong Zhou, Guo‐Ying Sun, Tian Liu, Yong‐Ping Liu, Cha‐Xiang Guan Tags: Original Article Source Type: research

Influence of dietary supplementation with flaxseed and lactobacilli on the mucosal morphology and proliferative cell rate in the jejunal mucosa of piglets after weaning
Summary The aim of the study was to investigate the influence of flaxseed and lactobacilli supplementation to the diet of piglets during the time period between 10 days before and 21 days after weaning. The morphometry of the jejunal mucosa and proliferative ratio of both epithelial and lamina propria cells were compared with those found in a group of piglets fed with the usual diet added with sunflower oil during the same time period. The addition of flaxseed oil to the diet significantly increased the crypt depth in comparison with both groups supplemented with sunflower (P < 0.05 and 0.001 respectively) on the we...
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Zuzana Jonecova, Stefan Toth, Rachele Ciccocioppo, Luis Rodrigo, Peter Kruzliak, Radomira Nemcova Tags: Original Article Source Type: research

Insulin‐like growth factor‐1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression
This study suggests that IGF‐1R expression could be associated with better clinical outcome in cHL but is significantly associated with the expression of MET receptor. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 1, 2015 Category: Pathology Authors: Young Wha Koh, Dok Hyun Yoon, Cheolwon Suh, Hee Jeong Cha, Jooryung Huh Tags: Original Article Source Type: research