International Journal of Experimental Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma
Summary Pancreatic cancer is the fourth most common cause of cancer‐related mortality. Novel molecular biomarkers need to be identified for personalized medicine and to improve survival. The aim of this study was to examine chloride intracellular channel 4 (CLIC4) and Indian Hedgehog (Ihh) expression in benign and malignant lesions of the pancreas and to examine the eventual association between CLIC4 and Ihh expression, with clinicopathological features and prognosis of pancreatic cancer. A retrospective study of specimens collected from January 2000 to December 2011 at the Department of Pathology of the Second and Third...
Source: International Journal of Experimental Pathology - February 15, 2017 Category: Pathology Authors: Qiong Zou, Zhulin Yang, Daiqiang Li, Ziru Liu, Yuan yuan Tags: Original Article Source Type: research

Acute effects of phenylbutyrate on glutamine, branched ‐chain amino acid and protein metabolism in skeletal muscles of rats
Summary Phenylbutyrate (PB) acts as chemical chaperone and histone deacetylase inhibitor, which is used to decrease ammonia in urea cycle disorders and has been investigated for use in the treatment of a number of lethal illnesses. We performed in vivo and in vitro experiments to examine the effects of PB on glutamine (GLN), branched‐chain amino acid (BCAA; valine, leucine and isoleucine) and protein metabolism in rats. In the first study, animals were sacrificed one hour after three injections of PB (300mg/kg b.w.) or saline. In the second study, soleus (SOL, slow twitch) and extensor digitorum longus (EDL, fast twitc...
Source: International Journal of Experimental Pathology - February 1, 2017 Category: Pathology Authors: Milan Holecek, Melita Vodenicarovova, Pavel Siman Tags: Original Article Source Type: research

Models to define the stages of articular cartilage degradation in osteoarthritis development
Summary Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary car...
Source: International Journal of Experimental Pathology - February 1, 2017 Category: Pathology Authors: Blandine Poulet Tags: Review Article Source Type: research

Grape juice concentrate alleviates epididymis and sperm damage in cadmium ‐intoxicated rats
In conclusion, our study indicates long‐term GJC as a promising therapy against reproductive chemical intoxication injury damage, preserving sperm prior to ejaculation. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - February 1, 2017 Category: Pathology Authors: Celina de A. Lamas, Livia Cuquetto ‐Leite, Emanueli Nascimento da Silva, Bruna F. Thomazini, Gabriel da S. Cordeiro, Fabrícia de S. Predes, Andrea P.B. Gollücke, Heidi Dolder Tags: Original Article Source Type: research

British Society for Matrix Biology / Bone Research Society Third Joint Meeting: Autumn 2015 Meeting Report
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 28, 2016 Category: Pathology Tags: Abstract Source Type: research

Issue Information
(Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 28, 2016 Category: Pathology Tags: Issue Information Source Type: research

Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A ‐induced liver fibrosis in male rats
Summary Bisphenol A (BPA) is a key monomer in the production of plastics. It has been shown to be hepatotoxic. Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of chronic exposure to BPA on the development of hepatic fibrosis in male rats and to determine the cross‐talk between the hepatic cytokine network, oxidative stress and apoptosis. For this purpose, 30 male Wistar albino rats were divided into three equal groups as follows: the first group was given no treatment (normal control gro...
Source: International Journal of Experimental Pathology - December 6, 2016 Category: Pathology Authors: Sahar El ‐Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasan Tags: Original Article Source Type: research

Fish pollutants MeHg and Aroclor cause permanent structural damage in male gonads and kidneys after prepubertal exposure
In conclusion, fish pollutants MeHg and Aroclor caused permanent structural damage in male gonads and kidneys after prepubertal exposure, without showing clear chemical interactions. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 4, 2016 Category: Pathology Authors: Mariana S. Garcia, Dulce Helena J. Constantino, Ana P. G. Silva, Juliana E. Perobelli Tags: Original Article Source Type: research

Fish pollutants MeHg and Aroclor cause permanent structural damage in male gonad and kidney after prepubertal exposure
In conclusion, fish pollutants MeHg and Aroclor caused permanent structural damage in male gonads and kidneys after prepubertal exposure, without showing clear chemical interactions. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 4, 2016 Category: Pathology Authors: Mariana S. Garcia, Dulce Helena J. Constantino, Ana P. G. Silva, Juliana E. Perobelli Tags: Original Article Source Type: research

Neonatal exposure to ethinylestradiol increases ventral prostate growth and promotes epithelial hyperplasia and inflammation in adult male gerbils
This study demonstrated that the exposure to EE during postnatal development causes histophysiological alterations in this gland, predisposing to the development of prostatic lesions during life. These results are important for public health, considering that women worldwide have commonly used EE. Moreover, the bioaccumulation of this chemical has increased in different ecosystems. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 4, 2016 Category: Pathology Authors: Luiz R. Falleiros ‐Júnior, Ana P. S. Perez, Sebastião R. Taboga, Fernanda C. A. Santos, Patrícia S. L. Vilamaior Tags: Original Article Source Type: research

Low ‐level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical‐size defects and increases TGF‐β, FGF‐2, OPG/RANK and osteocalcin expression
Summary The aim of this study was to evaluate the effect of collagen sponge scaffold (CSS) implantation associated with low‐level laser therapy (LLLT) on repairing bone defects. A single 5‐mm cranial defect was surgically created in forty Wistar rats, which then received one of the following four interventions (n = 10 per group): no treatment (G0); bone defect implanted with collagen sponge scaffold (CSS) alone (G1); defect treated with low‐level laser therapy (LLLT) (wavelength 780 nm; total energy density 120 J/cm2; power 50 mW) alone (G2); and CSS associated with LLLT treatment (G3). After surgery, animals in...
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Lana Sarita de Souza Oliveira, Aurigena Antunes Ara újo, Raimundo Fernandes Araújo Júnior, Carlos Augusto Galvão Barboza, Boniek Castillo Dutra Borges, José Sandro Pereira Silva Tags: Original Article Source Type: research

Neuromuscular junctions (NMJs): ultrastructural analysis and nicotinic acetylcholine receptor (nAChR) subunit mRNA expression in offspring subjected to protein restriction throughout pregnancy
In conclusion, our results demonstrate that a low‐protein diet (6%) imposed throughout pregnancy impairs the expression of mRNAs encoding the nAChR α, γ and ε subunits in EDL NMJs and promotes morphological changes in SOL NMJs of 30‐day‐old offspring, indicating specific differences among muscle types following long‐term maternal protein restriction. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Paula Aiello Tom é de Souza Castro, Ludimila Canuto Faccioni, Patrícia Aline Boer, Robson Francisco Carvalho, Selma Maria Michelin Matheus, Maeli Dal‐Pai‐Silva Tags: Original Article Source Type: research

Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice
In conclusion, our results indicate that female C57BL/6 mice have a progressive age‐dependent loss of subcutaneous and visceral WAT browning, and this process runs in parallel with BAT morphological changes towards a fat storer phenotype, independent of cycling or disturbances in glucose metabolism. (Source: International Journal of Experimental Pathology)
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Leidyanne Ferreira Gon çalves, Thaissa Queiroz Machado, Camila Castro‐Pinheiro, Nathalia Guimaraes Souza, Karen Jesus Oliveira, Caroline Fernandes‐Santos Tags: Original Article Source Type: research

Fell Muir Review: Collagen fibril formation in  vitro and in vivo
Summary It is a great honour to be awarded the Fell Muir Prize for 2016 by the British Society of Matrix Biology. As recipient of the prize, I am taking the opportunity to write a minireview on collagen fibrillogenesis, which has been the focus of my research for 33 years. This is the process by which triple helical collagen molecules assemble into centimetre‐long fibrils in the extracellular matrix of animals. The fibrils appeared a billion years ago at the dawn of multicellular animal life as the primary scaffold for tissue morphogenesis. The fibrils occur in exquisite three‐dimensional architectures that match the ...
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Karl E. Kadler Tags: Review Article Source Type: research

Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit ‐eating bats (Artibeus lituratus)
We examined the effects of low, commercially recommended concentrations (0, 1.05 and 2.1 g/l) of an organochlorine insecticide endosulfan (EDS) formulation on oxidative responses in the liver and kidneys of Neotropical fruit bats (Artibeus lituratus), as well as possible liver morphological alterations following a 35‐day oral exposure. Superoxide dismutase activity was significantly decreased upon exposure to 1.05 g/l of EDS in the liver and kidneys, catalase was decreased in the liver of 2.1 g/l EDS‐exposed bats, while glutathione S‐transferase was increased in the liver of 2.1 g/l EDS‐exposed bats. Protein ca...
Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Jerusa Maria Oliveira, Alessandro Brinati, Liany Divina Lima Miranda, Danielle Barbosa Morais, Jos é Cola Zanuncio, Reggiani Vilela Gonçalves, Maria do Carmo Gouveia Peluzio, Mariella Bontempo Freitas Tags: Original Article Source Type: research