Neuromuscular junctions (NMJs): ultrastructural analysis and nicotinic acetylcholine receptor (nAChR) subunit mRNA expression in offspring subjected to protein restriction throughout pregnancy

In conclusion, our results demonstrate that a low‐protein diet (6%) imposed throughout pregnancy impairs the expression of mRNAs encoding the nAChR α, γ and ε subunits in EDL NMJs and promotes morphological changes in SOL NMJs of 30‐day‐old offspring, indicating specific differences among muscle types following long‐term maternal protein restriction.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fiep.12229

Source: International Journal of Experimental Pathology - December 1, 2016 Category: Pathology Authors: Paula Aiello Tom é de Souza Castro, Ludimila Canuto Faccioni, Patrícia Aline Boer, Robson Francisco Carvalho, Selma Maria Michelin Matheus, Maeli Dal‐Pai‐Silva Tags: Original Article Source Type: research