Cytochrome P4503A activity affects the gender difference in the development of steroid‐induced osteonecrosis in rabbits

In conclusion, this study indicates that the gender difference in cytochrome P4503A activity may be one of the important factors for the development of steroid‐induced ON, possibly due to the effects of oestradiol.

Source: International Journal of Experimental Pathology - October 28, 2013 Category: Pathology Authors: Satoshi Ikemura, Takuaki Yamamoto, Goro Motomura, Ryosuke Yamaguchi, Garida Zhao, Kenyu Iwasaki, Yukihide Iwamoto Tags: Original Article Source Type: research