Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin

Summary Transplantable murine melanomas are well‐established models for the study of experimental cancer therapies. The aim of this study was to analyse the behaviour of four different B16 murine melanoma cell sublines after inoculation in C57BL/6J host, more specifically skin‐targeted analysis, with respect to two parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non‐invasive and invasive determinations showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, succeeded by B16F10 and followed in a similar diminished manner of aggressiveness by B16GMCSF and B16FLT3 cell lines.
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Tags: Original Article Source Type: research