Decreased expression of EphA5 is associated with Fuhrman nuclear grade and pathological tumour stage in ccRCC

In this study, a set of clear cell renal cell carcinoma (ccRCC) tissues were subjected to immunohistochemistry. The relationship between EphA5 protein expression and clinicopathological parameters was statistically analysed. Our data show that EphA5 protein was negatively (0) or weakly (1+) expressed in 48 of 78 (61.5%), moderately (2+) expressed in 15 of 78 (19.2%) and strongly (3+) expressed in 15 of 78 (19.2%) tumour samples of ccRCC. Decreased expression of EphA5 was detected more often in females than in males (P = 0.017, rs = −0.267). Expression of EphA5 was related negatively to Fuhrman grade (P = 0.013, rs = −0.279) and pathological tumour stage pT (P = 0.003, rs = −0.334). No relation between the expression of EphA5 and age of patients was found (P = 0.107, rs = 0.184). Fuhrman grade and pT stage are the most important factors used in prognosis of ccRCC. Hence this study may provide a new and useful prognostic marker in the clinical practice of ccRCC.
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Tags: Original Article Source Type: research