Hypermethylation of ATP ‐binding cassette B1 (ABCB1) multidrug resistance 1 (MDR1) is associated with cisplatin resistance in the A549 lung adenocarcinoma cell line

In conclusion, this in vitro and human tissue study of lung adenocarcinoma cells demonstrated that hypermethylation of the ABCB1 gene correlated with increased gene expression and was associated with the acquisition of resistance to the cisplatin analogue, DDP in human lung adenocarcinoma cells. Taken together, our study highlighted the connection between increased ABCB1 methylation level and upregulated expression of the gene in lung cancer. Moreover, the abnormally high expression of ABCB1 in A549 cells contributed to the development of the DDP resistance.

Source: International Journal of Experimental Pathology - July 31, 2016 Category: Pathology Authors: Angui Li, Jianfei Song, Qi Lai, Bangqing Liu, Haiyong Wang, Yinhui Xu, Xiaoyan Feng, Xiaolin Sun, Zhenzong Du Tags: Original Article Source Type: research