BIOCHEMICAL EVOLUTION: THE PURSUIT OF PERFECTION 2nd Edition Written by Athel Cornish ‐Bowden Garland Science $49.95; £29.95; EUR 42,00
(Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Nigel Loveridge Tags: BOOK REVIEW Source Type: research
Modulation of brown adipocyte activity by milk by ‐products: Stimulation of brown adipogenesis by buttermilk
Brown adipocytes dissipate chemical energy in the form of heat through the expression of mitochondrial uncoupling protein 1 (Ucp1); Ucp1 expression is further upregulated by the stimulation of β‐adrenergic receptors in brown adipocytes. An increase in energy expenditure by activated brown adipocytes potentially contributes to the prevention of or therapeutics for obesity. The present study examined the effects of milk by‐products, buttermilk and butter oil, on brown adipogenesis and the function of brown adipocytes. The treatment with buttermilk modulated brown adipogenesis, depending on the product tested; during bro...
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Hiroki Asano, Ryosuke Kida, Kengo Muto, Takayuki Y. Nara, Ken Kato, Osamu Hashimoto, Teruo Kawada, Tohru Matsui, Masayuki Funaba Tags: RESEARCH ARTICLE Source Type: research
Micro RNA ‐550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes
In conclusion, miR‐550a mediates the TNF‐α‐induced suppression of cyp27b1 expression in peripheral B cells of patients with diabetes, which can be blocked by inhibition of miR‐550a. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Jinggui He, Xiyun Guo, Zhi ‐Qiang Liu, Ping‐Chang Yang, Shaobo Yang Tags: RESEARCH ARTICLE Source Type: research
Strain ‐ and time‐dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis
The objective of this study was to investigate the contributions of inflammation and oxidative stress to altered hepatic iron metabolism in a murine model of NASH using inbred strains of mice with differing susceptibilities to injury. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Steven A. Bloomer, Alicia K. Olivier, Ottar M. Bergmann, M. Meleah Mathahs, Kimberly A. Broadhurst, Hasan Hicsasmaz, Kyle E. Brown Tags: RESEARCH ARTICLE Source Type: research
A possible S ‐glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study
This study suggests that glyoxalase II, through a specific interaction of its catalytic site with target proteins, could be able to perform a rapid and specific protein S‐glutathionylation using its natural substrate S‐d‐lactoylglutathione.
SignificanceThis article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S‐glutathionylation using its natural substrate SLG, a glutathione derived compound. In this perspective, Glo2 can play a new important regulatory role inS‐glutathionylation, acquiring further significance in cellular post‐t...
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Luisa Ercolani, Andrea Scir è, Roberta Galeazzi, Luca Massaccesi, Laura Cianfruglia, Adolfo Amici, Francesco Piva, Lorena Urbanelli, Carla Emiliani, Giovanni Principato, Tatiana Armeni Tags: RESEARCH ARTICLE Source Type: research
Regulation mechanism of PDK1 on macrophage metabolism and function
PDK1 is a member of the atypical glandular cell kinases family that regulates the activities of most atypical glandular cell kinases during different development stages and treatment of cancers. PDK1 is also a critical glucose metabolism enzyme regulating glucolysis or glucose oxidase in cells, and more research is needed to further understand the underlying mechanism. The research of PDK1 presented by recent studies focuses much on cancer treatment and has helped researchers gain much insight in this regard. Given the close relationship between inflammation and cancer, it is of great significance to discover the function ...
Source: Cell Biochemistry and Function - December 8, 2016 Category: Biochemistry Authors: Yueqin Yang, Weiwei Kong, Zhi Xia, Lin Xiao, Song Wang Tags: REVIEW ARTICLE Source Type: research
Mitochondrial ryanodine ‐sensitive Ca2+ channels of rat liver
To examine ryanodine‐sensitive Ca2+ channels in mitochondria of rat hepatocytes and their role in energy state of the cells via investigation of the ryanodine effect on mitochondrial membrane potential.
Oxygen consumption was measured by polarography using the Clark electrode. The substrates of oxidation such as pyruvate (5mM), α‐ketoglutarate (5mM), or succinate (5mM) were used. Oxidative phosphorylation was stimulated by the addition of adenosine diphosphate (200nM). Mitochondrial membrane potential was measured using a voltage‐sensitive fluorescent probe tetramethylrhodamine‐methyl‐ester (0.1μM) and was anal...
Source: Cell Biochemistry and Function - November 30, 2016 Category: Biochemistry Authors: N.I. Kupynyak, O.V. Ikkert, S.G. Shlykov, L.G. Babich, V.V. Manko Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - November 30, 2016 Category: Biochemistry Tags: Issue Information Source Type: research
ZAK β antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα
In this study, we show that the expression of ZAKα activated apoptosis through both a FAS‐dependent pathway and a mitochondria‐dependent pathway by subsequently inducing caspase‐3. ZAKβ, an isoform of ZAKα, is dramatically expressed during cardiac hypertrophy and apoptosis. The interaction between ZAKα and ZAKβ was demonstrated here using immunoprecipitation. The results show that ZAKβ has the ability to diminish the expression level of ZAKα. These findings reveal an inherent regulatory role of ZAKβ to antagonize ZAKα and to subsequently downregulate the cardiac hypertrophy and apoptosis induced by ZAKα. (S...
Source: Cell Biochemistry and Function - November 15, 2016 Category: Biochemistry Authors: Chien ‐Yao Fu, Wei‐Wen Kuo, Tsung‐Jung Ho, Su‐Ying Wen, Ling‐Chun Lin, Yan‐Shen Tseng, Hui‐Chuan Hung, Vijaya Padma Viswanadha, Jaw‐Ji Yang, Chih‐Yang Huang Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐383 is a tumor suppressor in human lung cancer by targeting endothelial PAS domain‐containing protein 1
Lung cancer is the deadliest of all human cancers worldwide. The role of microRNA (miR)‐383 has been controversial in the initiation and progression of different cancers. We aimed to investigate the function of miR‐383 in human lung cancer both in vitro and in vivo. MicroRNA‐383 levels were analyzed in noncancerous versus cancerous human lung tissues and in normal versus lung cancer cell lines. Effect of miR‐383 on cell migration and invasion was examined in vitro and on tumor growth by using a xenograft mouse model in vivo. Potential mRNA target of miR‐383 was predicted, and underlying mechanism was explored as ...
Source: Cell Biochemistry and Function - November 14, 2016 Category: Biochemistry Authors: Hongjing Ma, Bin Liu, Shuoying Wang, Jing Liu Tags: RESEARCH ARTICLE Source Type: research
Role of the p38 mitogen ‐activated protein kinase signaling pathway in estrogen‐mediated protection following flap ischemia‐reperfusion injury
This study provides an explanation for how estrogen alleviates I/R injury‐induced damage that occurs during skin flap transplantation. In a rat pathological model, I/R injury leads to skin necrosis, skin structure damage, neutrophil infiltration, and inflammatory cytokine secretion, which are probably downstream effects of activation of the p38‐MAPK pathway. On the other hand, estradiol treatment triggers the expression of MAPK phosphatase‐2, a putative phosphatase of p38‐MAPK, and reduced all examined pathological phenomena. Therefore, estrogen may reduce the deleterious effect of I/R injury on skin flap transplan...
Source: Cell Biochemistry and Function - October 16, 2016 Category: Biochemistry Authors: JiHui Ju, JianLong Wu, RuiXing Hou Tags: RESEARCH ARTICLE Source Type: research
The 37 ‐kDa laminin receptor precursor regulates the malignancy of human glioma cells
In this study, we found the higher expression of 37LRP in the glioma cells compared with the normal brain cells. We also indicated that the downregulation of 37LRP could affect the glioma biomarker expression and also weaken the proliferative, migratory, and metastatic capacity of glioma cells in vitro. Furthermore, 37LRP silencing inhibited the glioma tumor growth in vivo. Collectively, these data demonstrated that 37LRP regulates the metastasis of glioma cells in vitro and tumor growth in vivo, suggesting that 37LRP may function as a potential molecular target in the glioma treatment. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - October 16, 2016 Category: Biochemistry Authors: Hongjie Wu, Jing Li, Dongxiao Xu, Donghui Jv, Xiaofeng Meng, Peng Qiao, Tao Cui, Baozhong Shi Tags: RESEARCH ARTICLE Source Type: research
Serum miR ‐221 serves as a biomarker for Parkinson's disease
This study aims to investigate the potential of 16 previous reported PD‐associated miRNAs as novel biomarkers for PD. The expression of 16 serum miRNAs was measured by quantitative reverse transcriptase polymerase chain reaction in 138 PD patients and 112 control populations. Analyses were undertaken to assess the specificity and sensitivity of miRNAs to predict PD. In addition, the relationship between deregulated miRNAs and Part III of the United Parkinson's Disease Rating Scale (UPDRS‐III) and Part V of the UPDRS (UPDRS‐V; the modified Hoehn and Yahr staging of PD) in PD patients was also assessed. It was found th...
Source: Cell Biochemistry and Function - October 16, 2016 Category: Biochemistry Authors: Wenbin Ma, Yingying Li, Chao Wang, Fan Xu, Meiling Wang, Yiming Liu Tags: RESEARCH ARTICLE Source Type: research
miR ‐204‐5p targeting SIRT1 regulates hepatocellular carcinoma progression
This study aimed to investigate the cellular function and molecular mechanism of miR‐204‐5p in HCC. SIRT1 mRNA and miR‐204‐5p were examined by real‐time reverse transcription polymerase chain reaction. SIRT1 protein levels were measured by Western blotting. Cell proliferation assay was performed to confirm colony formation. Invasion assay was performed by transwell system. SPSS 15.0 for Windows was used for statistical analysis. SIRT1 was a potential oncogene in cancer, which was identified as a direct target of miR‐204‐5p. Overexpression of miR‐204‐5p in human HCC cell lines (BEL‐7405 and QGY‐7701) c...
Source: Cell Biochemistry and Function - October 16, 2016 Category: Biochemistry Authors: Guangbin Jiang, Li Wen, Hongmei Zheng, Zhiyuan Jian, Weiping Deng Tags: RESEARCH ARTICLE Source Type: research
Gene expression profiles of human subcutaneous and visceral adipose ‐derived stem cells
Subcutaneous and visceral adipose tissues show a different risk effect on metabolic disorders because they have distinct cellular properties. We isolated stem cells from the separate human adipose tissues to investigate that subcutaneous and visceral fat depots have metabolic differences. Adipose‐derived stem cells (ASCs) were characterized by immunophenotype and differentiation potentials into adipogenic, osteogenic, and chondrogenic lineages. Although subcutaneous and visceral ASCs (S‐ASC and V‐ASC) express same surface markers (CD31−, CD34−, CD45−, CD73+, CD90+, and CD105+) and have differentiation potential...
Source: Cell Biochemistry and Function - September 30, 2016 Category: Biochemistry Authors: Boyun Kim, Boram Lee, Mi ‐Kyung Kim, Seung Pyo Gong, Noh Hyun Park, Hyun Hoon Chung, Hee Seung Kim, Jae Hong No, Woong Yang Park, Ae Kyung Park, Jeong Mook Lim, Yong Sang Song Tags: RESEARCH ARTICLE Source Type: research
