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Cell Biochemistry and Function,Volume 36, Issue 2, Page 80-87, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 25, 2018 Category: Biochemistry Source Type: research
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Cell Biochemistry and Function,Volume 36, Issue 2, Page 88-94, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 25, 2018 Category: Biochemistry Source Type: research
Mesenchymal stem cells promote cell invasion and migration and autophagy ‐induced epithelial‐mesenchymal transition in A549 lung adenocarcinoma cells
Mesenchymal stem cells (MSCs) are recruited into the tumour microenvironment and promote tumour growth and metastasis. Tumour microenvironment‐induced autophagy is considered to suppress primary tumour formation by impairing migration and invasion. Whether these recruited MSCs regulate tumour autophagy and whether autophagy affects tumour growth are controversial. Our data showed that MSCs promote autophagy activation, reactive oxygen species production, and epithelial‐mesenchymal transition (EMT) as well as increased migration and invasion in A549 cells. Decreased expression of E‐cadherin and increased expression of...
Source: Cell Biochemistry and Function - January 25, 2018 Category: Biochemistry Authors: Dan Luo, Shiyuan Hu, Chunlan Tang, Guoxiang Liu Tags: RESEARCH ARTICLE Source Type: research
Quantitative proteomics reveals that miR ‐222 inhibits erythroid differentiation by targeting BLVRA and CRKL
Cell Biochemistry and Function,Volume 36, Issue 2, Page 95-105, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 24, 2018 Category: Biochemistry Source Type: research
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Cell Biochemistry and Function,Volume 36, Issue 2, Page 95-105, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 24, 2018 Category: Biochemistry Source Type: research
ILEI is an important intermediate participating in the formation of TGF ‐β1–induced renal tubular EMT
Cell Biochemistry and Function,Volume 36, Issue 2, Page 46-55, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 15, 2018 Category: Biochemistry Source Type: research
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Cell Biochemistry and Function,Volume 36, Issue 2, Page 46-55, March 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 15, 2018 Category: Biochemistry Source Type: research
Telmisartan ameliorates vascular endothelial dysfunction in coronary slow flow phenomenon (CSFP)
Coronary slow flow phenomenon (CSFP) is a coronary microvascular disorder with an increasing morbidity, and currently, available therapies are of limited clinical value for its cure. Hence, it is urgent to find a novel approach to CSFP treatment. Several studies show that endothelial dysfunction plays a critical role in the aetiology of CSFP. Telmisartan (TMST) is a clinically available anti‐hypertensive medicine and has shown its potential properties for improving vascular endothelial function. Thus, we aimed to investigate the effect of TMST on endothelial dysfunction in CSFP, Endothelial‐dependent flow‐mediated va...
Source: Cell Biochemistry and Function - January 8, 2018 Category: Biochemistry Authors: Zhe Jin, Qindong Tan, Bei Sun Tags: RESEARCH ARTICLE Source Type: research
Cancer cells govern miR ‐2909 exosomal recruitment through its 3′‐end post‐transcriptional modification
It is widely believed that selective packaging of nucleic acids, especially microRNAs, into exosomes secreted by the cancer cells not only ensures their growth and survival but also helps in the escape from immune surveillance. Keeping in view the fact that human cellular miR‐2909 has emerged to regulate genes involved in oncogenesis and immunity, the present study was addressed to reveal the nature of miR‐2909 expression within cancer cells of different tissue origin and its incorporation into exosomes secreted by these cells. Post‐transcriptional modification, especially 3′‐end adenylation and uridylation of mi...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Sameena Wani, Deepak Kaul Tags: RESEARCH ARTICLE Source Type: research
GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis
GdX, also named ubiquitin‐like protein 4A, is a ubiquitin‐domain protein characterized by a ubiquitin‐like domain that regulates the movement of misfolded proteins from the endoplasmic reticulum membrane to proteasome. However, its function in skeletal biology remains unclear. Here, we report that GdX plays a crucial role in skeletal development as mice lacking GdX exhibit skeletal dysplasias, mild kyphosis, and scoliosis. During embryonic stage, GdX knockout mice display decreased bone mineral density and trabecular bone accompanied by delayed osteogenic formation. GdX knockout mice also have blended spine and small...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Jiao Liang, Jun Li, Yanxia Fu, Fangli Ren, Jiake Xu, Mengyu Zhou, Peiyu Li, Haotian Feng, Yinyin Wang Tags: RESEARCH ARTICLE Source Type: research
ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia
This study proved that mechano‐growth factor E (MGF E) peptide could improve the severe hypoxia‐induced cell contraction and decline of cell adhesion and migration of BMSCs. Besides, MGF E peptide weakened the effects of severe hypoxia on the cytoskeleton arrangement‐ and mobility‐relevant protein expression levels in BMSCs. The underlying molecular mechanism was also verified. Finally, it was confirmed that MGF E peptide showed an adverse effect on the expression level of vascular endothelial growth factor α in BMSCs under severe hypoxia but could make up for this deficiency through accelerating cell proliferatio...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Yongqiang Sha, Li Yang, Yonggang Lv Tags: RESEARCH ARTICLE Source Type: research
DJ ‐1 plays an obligatory role in the cardioprotection of delayed hypoxic preconditioning against hypoxia/reoxygenation‐induced oxidative stress through maintaining mitochondrial complex I activity
DJ‐1 was recently reported to mediate the cardioprotection of delayed hypoxic preconditioning (DHP) by suppressing hypoxia/reoxygenation (H/R)‐induced oxidative stress, but its mechanism against H/R‐induced oxidative stress during DHP is not fully elucidated. Here, using the well‐established cellular model of DHP, we again found that DHP significantly improved cell viability and reduced lactate dehydrogenase release with concurrently up‐regulated DJ‐1 protein expression in H9c2 cells subjected to H/R. Importantly, DHP efficiently improved mitochondrial complex I activity following H/R and attenuated H/R‐induc...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Hao Ding, Xing ‐Wang Xu, Huan Wang, Lin Xiao, Le Zhao, Guang‐Ling Duan, Xiao‐Ran Li, Zhao‐Xia Ma, He‐Ping Chen Tags: RESEARCH ARTICLE Source Type: research
Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells
Autophagy plays a major role in the adaptive metabolic response of cancer cells during adverse conditions such as nutrient deprivation. However, specific data that assess metabolite profiles in context with adenosine triphosphate (ATP) availability and cell death susceptibility remain limited. Human breast cancer cells, MDAMB231, and normal breast epithelial cells, MCF12A, were subjected to short‐term amino acid starvation and the cellular apoptotic and autophagic responses assessed. The role of autophagy in the control of cellular amino acid, ATP, free fatty acid, and glucose levels during amino acid starvation were com...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Mark Thomas, Tanja Davis, Ben Loos, Balindiwe Sishi, Barbara Huisamen, Hans Strijdom, Anna ‐Mart Engelbrecht Tags: RESEARCH ARTICLE Source Type: research
Fish bone peptide promotes osteogenic differentiation of MC3T3 ‐E1 pre‐osteoblasts through upregulation of MAPKs and Smad pathways activated BMP‐2 receptor
The objective of this study was to investigate the effects of a bioactive peptide isolated from the bone of the marine fish, Johnius belengerii, on the osteoblastic differentiation of MC3T3‐E1 pre‐osteoblasts. Post consecutive purification by liquid chromatography, a potent osteogenic peptide, composed of 3 amino acids, Lys‐Ser‐Ala (KSA, MW: 304.17 Da), was identified. The purified peptide promoted cell proliferation, alkaline phosphatase activity, mineral deposition, and expression levels of phenotypic markers of osteoblastic differentiation in MC3T3‐E1 pre‐osteoblast. The purified peptide induced phosphoryla...
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Seong ‐Yeong Heo, Seok‐Chun Ko, Seung Yun Nam, Junghwan Oh, Young‐Mog Kim, Jae‐Il Kim, Namwon Kim, Myunggi Yi, Won‐Kyo Jung Tags: RESEARCH ARTICLE Source Type: research
Inhibition of the CSF ‐1 receptor sensitizes ovarian cancer cells to cisplatin
This study may help to increase understanding of the molecular mechanisms underlying cisplatin resistance in tumours. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Rong Yu, Hao Jin, Congcong Jin, Xuefeng Huang, Jinju Lin, Yili Teng Tags: RESEARCH ARTICLE Source Type: research
