ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia

This study proved that mechano‐growth factor E (MGF E) peptide could improve the severe hypoxia‐induced cell contraction and decline of cell adhesion and migration of BMSCs. Besides, MGF E peptide weakened the effects of severe hypoxia on the cytoskeleton arrangement‐ and mobility‐relevant protein expression levels in BMSCs. The underlying molecular mechanism was also verified. Finally, it was confirmed that MGF E peptide showed an adverse effect on the expression level of vascular endothelial growth factor α in BMSCs under severe hypoxia but could make up for this deficiency through accelerating cell proliferation.

Source: Cell Biochemistry and Function - January 1, 2018 Category: Biochemistry Authors: Yongqiang Sha, Li Yang, Yonggang Lv Tags: RESEARCH ARTICLE Source Type: research