Esophageal cancer‐derived microvesicles induce regulatory B cells
In conclusion, Eca‐derived Mvc can induce TGF‐β+ B cells; the latter suppress CD8+ T‐cell activities. The MMP9‐laden Mvcs may be a new therapeutic target in the treatment of Eca. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - May 25, 2015 Category: Biochemistry Authors: Yun Li, Jun An, Shaohong Huang, Jinyuan He, Junhang Zhang Tags: Research Article Source Type: research
Instant coffee extract with high chlorogenic acids content inhibits hepatic G‐6‐Pase in vitro, but does not reduce the glycaemia
Coffee is the main source of chlorogenic acid in the human diet, and it contains several chlorogenic acid isomers, of which the 5‐caffeoylquinic acid (5‐CQA) is the predominant isomer. Because there are no available data about the action of chlorogenic acids from instant coffee on hepatic glucose‐6‐phosphatase (G‐6‐Pase) activity and blood glucose levels, these effects were investigated in rats. The changes on G‐6‐Pase activity and liver glucose output induced by 5‐CQA were also investigated. Instant coffee extract with high chlorogenic acids content (37.8%) inhibited (p < 0.05) the G‐6‐Pase ac...
Source: Cell Biochemistry and Function - May 11, 2015 Category: Biochemistry Authors: Bruna Kempfer Bassoli, Priscila Cassolla, Glaucia Regina Borba‐Murad, Jorgete Constantin, Clairce Luzia Salgueiro‐Pagadigorria, Roberto Barbosa Bazotte, Helenir Medri Souza Tags: Research Article Source Type: research
PPAR‐α agonist elicits metabolically active brown adipocytes and weight loss in diet‐induced obese mice
This study aimed to examine the effects of fenofibrate on energy expenditure, body mass (BM) and gene expression of thermogenic factors in brown adipose tissue of diet‐induced obese mice. Male C57BL/6 mice were fed a standard chow (SC; 10% lipids) diet or a high‐fat (HF; 50% lipids) diet for 10 weeks. Afterwards, groups were subdivided as SC, SC‐F, HF and HF‐F (n = 10, each). Treatment with fenofibrate (100 mg kg−1 BM mixed into the diet) lasted 5 weeks. Treated groups had reduced final BM compared with their counterparts (p < 0·05), explained by the increase in energy expenditure, CO2 product...
Source: Cell Biochemistry and Function - May 11, 2015 Category: Biochemistry Authors: Tamiris Lima Rachid, Aline Penna‐de‐Carvalho, Isabele Bringhenti, Marcia Barbosa Aguila, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello Tags: Research Article Source Type: research
Amyloid beta peptide (1–42)‐mediated antioxidant imbalance is associated with activation of protein kinase C in red blood cells
Glycolysis and pentose phosphate pathway (PPP) in red blood cell (RBC) are modulated by the cell oxygenation state. This metabolic modulation is connected to variations in intracellular nicotinamide adenine dinucleotide phosphate‐reduced form (NADPH) and adenosine triphosphate (ATP) levels as a function of the oxygenation state of the cell, and, consequently, it should have physiologic relevance. In the present study, we analysed the effects of amyloid beta peptide (1–42) (Abeta) on RBC metabolism and its relationship with the activity of protein kinase C (PKC). Our results showed that metabolic response to Abeta depen...
Source: Cell Biochemistry and Function - April 23, 2015 Category: Biochemistry Authors: Cristiana Carelli‐Alinovi, Bruno Giardina, Francesco Misiti Tags: Research Article Source Type: research
Chinese medicine Tongxinluo increases tight junction protein levels by inducing KLF5 expression in microvascular endothelial cells
Tongxinluo (TXL) is a compound prescription formulated according to the meridian theory of traditional Chinese medicine. It may play an important role in cardiovascular protection by improving endothelial cell function. The aim of present study was to investigate whether endothelial protection with TXL is related to its regulation of tight junction protein expression. Human cardiac microvascular endothelial cells (HCMECs) were cultured and treated with 10−7 mol l−1 angiotensin II (Ang II) and the different doses of TXL; the expression of tight junction proteins occludin, claudin, VE‐cadherin and beta‐catenin wa...
Source: Cell Biochemistry and Function - April 23, 2015 Category: Biochemistry Authors: Li‐Min Li, Bing Zheng, Ruo‐Nan Zhang, Li‐Shuang Jin, Cui‐Ying Zheng, Chang Wang, Pei‐Pei Zhou, Zong‐Wei Guo, Dong Ma, Jin‐Kun Wen Tags: Research Article Source Type: research
