Targeting ROR1 inhibits the self‐renewal and invasive ability of glioblastoma stem cells
Glioblastoma is the most malignant of brain tumours and is difficult to cure because of interruption of drug delivery by the blood–brain barrier system, its high metastatic capacity and the existence of cancer stem cells (CSCs). Although CSCs are present as a small population in malignant tumours, CSCs have been studied as they are responsible for causing recurrence, metastasis and resistance to chemotherapy and radiotherapy for cancer. CSCs have self‐renewal characteristics like normal stem cells. The aim of this study was to investigate whether receptor tyrosine kinase‐like orphan receptor 1 (ROR1) is involved in s...
Source: Cell Biochemistry and Function - February 29, 2016 Category: Biochemistry Authors: Eun‐Hwa Jung, Han‐Na Lee, Gi‐Yeon Han, Min‐Jung Kim, Chan‐Wha Kim Tags: Research Article Source Type: research
Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression
EPB41L3 may play a role as a metastasis suppressor by supporting regular arrangements of actin stress fibres and alleviating the increase in cell motility associated with enhanced metastatic potential. Downregulation of epb41l3 has been observed in many cancers, but the role of this gene in esophageal squamous cell carcinoma (ESCC) remains unclear. Our study aimed to determine the effect of epb41l3 on ESCC cell migration and invasion. We investigated epb41l3 protein expression in tumour and non‐tumour tissues by immunohistochemical staining. Expression in the non‐neoplastic human esophageal cell line Het‐1a and four ...
Source: Cell Biochemistry and Function - February 26, 2016 Category: Biochemistry Authors: Rong Zeng, Jun‐peng Huang, Xu feng Li, Wei‐bin Xiong, Gang Wu, Zhao‐jing Jiang, Shu‐jie Song, Ji‐qiang Li, Yan‐fang Zheng, Ji‐ren Zhang Tags: Research Article Source Type: research
A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT‐116 colon cancer cells
Colchicine is a tubulin‐binding natural product isolated from Colchicum autumnale. Here we report the in vitro anticancer activity of C‐ring modified semi‐synthetic derivative of colchicine; N‐[(7S)‐1,2,3‐trimethoxy‐9‐oxo‐10‐(4‐phenyl‐piperidin‐1‐yl)‐5,6,7,9 tetrahydrobenzo[a]heptalen‐7‐yl]acetamide (4h) on colon cancer HCT‐116 cell line. The compound 4h was screened for anti‐proliferative activity against different human cancer cell lines and was found to exhibit higher cytotoxicity against colon cancer cell lines HCT‐116 and Colo‐205 with IC50 of 1 and 0.8 μM respectively. Cyt...
Source: Cell Biochemistry and Function - February 25, 2016 Category: Biochemistry Authors: Ashok Kumar, Baljinder Singh, Parduman R. Sharma, Sandip B. Bharate, Ajit K. Saxena, D. M. Mondhe Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - February 25, 2016 Category: Biochemistry Tags: Issue Information Source Type: research
Circulating microRNAs, miR‐92a, miR‐100 and miR‐143, as non‐invasive biomarkers for bladder cancer diagnosis
This study explores the existence of specific plasma miRNAs as early diagnostic biomarkers for BC in Egyptian patients; and these findings suggest that plasma miR‐92a, miR‐100 and miR‐143 could be promising novel circulating biomarkers in clinical detection of BC. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - February 24, 2016 Category: Biochemistry Authors: Tarek Kamal Motawi, Sherine Maher Rizk, Taghreed Mahmoud Ibrahim, Ihab Abdel‐Rahman Ibrahim Tags: Research Article Source Type: research
Large animal models of cardiovascular disease
The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal mammalian processes. Despite our advancing knowledge and understanding of cardiovascular disease (CVD) through the principal use of rodent models, this continues to be an increasing issue in today's world. For instance, as the ageing population increases, so does the incidence of heart valve dysfunction. This may be because of changes in molecular composition and structure of ...
Source: Cell Biochemistry and Function - February 24, 2016 Category: Biochemistry Authors: H. G. Tsang, N. A. Rashdan, C. B. A. Whitelaw, B. M. Corcoran, K. M. Summers, V. E. MacRae Tags: Review Article Source Type: research
Activation of TLR5 induces podocyte apoptosis
In conclusion, TLR5 activation plays an important role in the induction of podocyte apoptosis. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - February 24, 2016 Category: Biochemistry Authors: Xu Lin, Haiting Huang, Yanwu You, Chunrong Tang, Xiangjun Gu, Meiying Huang, Junhua Tan, Jie Wang Tags: Research Article Source Type: research
Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes
The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator‐activated receptor (Ppar) γ coactivator‐1α (Pgc‐1α) and uncoupling protein 1 (Ucp1). Capsaicin has been suggested to induce the activation of brown adipocytes, which is mediated by the stimulation of sympathetic nerves. However, capsaicin may directly affect the differentiation of brown preadipocytes, brown adipocyte function, or both, through its significan...
Source: Cell Biochemistry and Function - January 18, 2016 Category: Biochemistry Authors: Ryosuke Kida, Hirofumi Yoshida, Masaru Murakami, Mitsuyuki Shirai, Osamu Hashimoto, Teruo Kawada, Tohru Matsui, Masayuki Funaba Tags: Research Article Source Type: research
Binding of B‐cell maturation antigen to B‐cell activating factor induces survival of multiple myeloma cells by activating Akt and JNK signaling pathways
In this study, we characterized the mechanism underlying the protein kinase B (Akt) and c‐Jun N‐terminal kinase (JNK) pathways and BCMA interactions in regulating multiple myeloma (MM) cell survival. It was found that the expression levels of B cell‐activating factor (BAFF) and BCMA were increased in MM cells as compared with those in normal controls. The proliferation of U266 cells was induced by recombinant human BAFF (rhBAFF) and could also be decreased by BCMA siRNA. The expression of Bcl‐2 protein was up‐regulated, and Bax protein was down‐regulated after rhBAFF treatment, which could be reversed by BCMA s...
Source: Cell Biochemistry and Function - January 1, 2016 Category: Biochemistry Authors: Xianjuan Shen, Yuehua Guo, Jing Qi, Wei Shi, Xinhua Wu, Shaoqing Ju Tags: Research Article Source Type: research
Protection against oxidative stress by vitamin D in cone cells
Photoreceptor degeneration (PD) refers to a group of heterogeneous outer retinal dystrophies characterized by the death of photoreceptors. Both oxidative stress and inflammation are involved in the pathogenesis of PD. We investigate whether vitamin D has a potential for the treatment of PD by evaluating the anti‐oxidative stress and anti‐inflammatory properties of the active form of vitamin D3, 1,α, 25‐dihydroxyvitamin D3, in a mouse cone cell line, 661W. Mouse cone cells were treated with H2O2 or a mixture of H2O2 and vitamin D; cell viability was determined. The production of reactive oxygen species (ROS) in treat...
Source: Cell Biochemistry and Function - January 1, 2016 Category: Biochemistry Authors: Ali Mohammad Tohari, Xinzhi Zhou, Xinhua Shu Tags: Research Article Source Type: research
Reduced expressions of calmodulin genes and protein and reduced ability of calmodulin to activate plasma membrane Ca2+‐ATPase in the brain of protein undernourished rats: modulatory roles of selenium and zinc supplementation
In conclusion, it is postulated that Se and Zn might be beneficial antioxidants in protecting against neuronal dysfunction resulting from reduced level of calmodulin such as present in protein undernutrition. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 1, 2016 Category: Biochemistry Authors: Olusegun L. Adebayo, Alka Khera, Rajat Sandhir, Gbenga A. Adenuga Tags: Research Article Source Type: research
The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide‐mediated vasorelaxation in BALB/c mice
There is strong evidence that vasodilatory nitric oxide (NO) donors have anabolic effects on bone in humans. Parathyroid hormone (PTH), the only osteoanabolic drug currently approved, is also a vasodilator. We investigated whether the NO synthase inhibitor L‐NAME might alter the effect of PTH on bone by blocking its vasodilatory effect. BALB/c mice received 28 daily injections of PTH[1–34] (80 µg/kg/day) or L‐NAME (30 mg/kg/day), alone or in combination. Hindlimb blood perfusion was measured by laser Doppler imaging. Bone architecture, turnover and mechanical properties in the femur were analysed respectively by...
Source: Cell Biochemistry and Function - January 1, 2016 Category: Biochemistry Authors: S Gohin, A Carriero, C Chenu, AA Pitsillides, TR Arnett, M Marenzana Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - January 1, 2016 Category: Biochemistry Tags: Issue Information Source Type: research
Corrigendum: BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin‐induced tau hyperphosphorylated rat model
(Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - December 21, 2015 Category: Biochemistry Tags: Corrigendum Source Type: research
Cyclophilin A as a downstream effector of PI3K/Akt signalling pathway in multiple myeloma cells
This study confirmed that Cyp A is a downstream effector of the phosphatidylinositide 3‐kinase (PI3K)/Akt signalling pathway. Cyp A was highly phosphorylated in response to interleukin‐6 treatment, which was consistent with the accumulation of phosphorylated Akt, suggesting that Cyp A is a phosphorylation target of Akt and downstream effector of the PI3K/Akt pathway. Cyclosporine A (CsA), a PPI inhibitor, inhibited the growth of multiple myeloma (MM) U266 cells. Moreover, CsA treatment inhibited the activation of the signal transducer and activator of transcription 3 (STAT3) in MM U266 cells. Several Cyp A mutants were...
Source: Cell Biochemistry and Function - December 21, 2015 Category: Biochemistry Authors: Zuo‐Lin Lin, Hsin‐Jou Wu, Jin‐An Chen, Kuo‐Chih Lin, Jung‐Hsin Hsu Tags: Research Article Source Type: research
