Expansion of adipose tissue ‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescence
Multipotent mesenchymal stromal cells are considered as a perspective tool in cell therapy and regenerative medicine. Unfortunately, autologous cell therapy does not always provide positive outcomes in elder donors, perhaps as a result of the alterations of stem cell compartments. The mechanisms of stem and progenitor cell senescence and the factors engaged are investigated intensively. In present paper, we elucidated the effects of tissue‐related O2 on morphology, functions, and transcriptomic profile of adipose tissue‐derived stromal cells (ASCs) in replicative senescence in vitro model. Replicatively senescent ASCs ...
Source: Cell Biochemistry and Function - June 6, 2017 Category: Biochemistry Authors: Andrey Ratushnyy, Margarita Lobanova, Ludmila B. Buravkova Tags: RESEARCH ARTICLE Source Type: research
All ‐trans retinoic acid upregulates the expression of ciliary neurotrophic factor in retinal pigment epithelial cells
In conclusion, our data suggest that ATRA administration upregulates CNTF expression in RPE cells. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - June 6, 2017 Category: Biochemistry Authors: Wen ‐Di Zhou, Lu‐Lu Wang, Lan‐Bo Zhou, Wei Bin, Tian‐Ping Bao, Yi Zhang, Jin Shu, Wei‐Xia Yang, Liang‐Liang Hui, Rui Jin, Li‐Li Zhuang, Guo‐Ping Zhou Tags: RESEARCH ARTICLE Source Type: research
SET domain ‐containing protein 5 is required for expression of primordial germ cell specification‐associated genes in murine embryonic stem cells
Primordial germ cell (PGC) specification is one of the most fundamental processes in developmental biology. Because PGCs are a common source of both gametes, generation of PGCs from embryonic stem cells (ESCs) is a useful model for analysing the germ line lineage. Although several studies focused on the role of epigenetic regulation on PGC differentiation from ESCs in vitro have been published, germ line commitment remains poorly understood. Here, we show that SET domain‐containing protein (Setd5), which has a previously unknown function, is essential for regulating germ cell‐associated genes in murine ESCs (mESCs). Ev...
Source: Cell Biochemistry and Function - June 1, 2017 Category: Biochemistry Authors: Seung Eun Yu, Min Seong Kim, Su Hyung Park, Byong Chul Yoo, Kyung Hee Kim, Yeun Kyu Jang Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - June 1, 2017 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Corrigendum: Strain ‐ and time‐dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis
(Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - April 24, 2017 Category: Biochemistry Authors: Steven A. Bloomer, Alicia K. Olivier, Ottar M. Bergmann, M. Meleah Mathahs, Kimberly A. Broadhurst, Hasan Hicsasmaz, Kyle E. Brown Tags: CORRIGENDUM Source Type: research
MicroRNA ‐10b regulates the renewal of spermatogonial stem cells through Kruppel‐like factor 4
MicroRNAs (miRs) are functionally important in spermatogenesis, which is the self‐renewal or differentiation of spermatogonial stem cells (SSCs). Here, we report a novel role for miR‐10b in regulating the self‐renewal of mouse SSCs. We showed that miR‐10b was highly expressed in mouse SSCs in vitro and enhanced SSC proliferation. Knockdown of miR‐10b significantly increased the apoptosis of SSCs compared with controls. Kruppel‐like factor 4 was found to be a target gene of miR‐10b in the enhancement of SSC proliferation. These findings further our understanding of the self‐renewal and differentiation of SSC...
Source: Cell Biochemistry and Function - April 24, 2017 Category: Biochemistry Authors: Jiang Li, Xiang Liu, Xiaopeng Hu, Geng G. Tian, Wenzhi Ma, Xiuying Pei, Yanrong Wang, Ji Wu Tags: RESEARCH ARTICLE Source Type: research
Cortisol is associated with low frequency of interleukin 10 –producing B cells in patients with atherosclerosis
This study tests a hypothesis that a psychological stress hormone, cortisol, suppresses IL‐10 expression in peripheral B cells of patients with atherosclerosis. Peripheral blood samples were collected from patients with coronary artery atherosclerosis. B cells were isolated from the blood samples to be analyzed for the expression of IL‐10 and micro RNA (miR) 98 by real‐time polymerase chain reaction. We observed that the frequency of IL‐10+ B cell was less in patients with atherosclerosis than healthy controls. The serum cortisol levels were higher in the patients than that in healthy controls. Peripheral B‐cell ...
Source: Cell Biochemistry and Function - April 24, 2017 Category: Biochemistry Authors: Yizhong Huo, Yan Chu, Lixin Guo, Linli Liu, Xiaojun Xia, Tierui Wang Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐141‐3p targets DAPK1 and inhibits apoptosis in rat ovarian granulosa cells
In this study, we aimed to characterize the target of miR‐141‐3p in rat ovarian granulosa cells. 3‐(4,5‐Dimethylthiazol‐2‐Yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) assay showed that cell viability was dramatically increased when miR‐141‐3p was overexpressed but was decreased when miR‐141‐3p was interfered. Flow cytometry showed that cell apoptotic rate was dramatically decreased when miR‐141‐3p was overexpressed but was increased when miR‐141‐3p was interfered. Bioinformatics analysis predicted that death‐associated protein kinase 1 (DAPK1) might be the target gene of miR‐141‐3p becaus...
Source: Cell Biochemistry and Function - April 1, 2017 Category: Biochemistry Authors: Dandan Li, Duo Xu, Ying Xu, Lu Chen, Chunjin Li, Xiaowei Dai, Lili Zhang, Lianwen Zheng Tags: RESEARCH ARTICLE Source Type: research
Gold nanoparticles –conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt–mediated pathway in breast cancer cell lines (MCF‐7 and MDA‐MB‐231)
In conclusion, administration of AuNPs‐Qu‐5 in breast cancer cell lines curtails cell proliferation through induction of apoptosis and also suppresses EGFR signalling. AuNPs‐Qu‐5 is more potent than free quercetin in causing cancer cell death, and hence, this could be a potential drug delivery system in breast cancer therapy. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - April 1, 2017 Category: Biochemistry Authors: Solaimuthu Balakrishnan, Sudip Mukherjee, Sourav Das, Firdous Ahmad Bhat, Paulraj Raja Singh, Chitta Ranjan Patra, Jagadeesan Arunakaran Tags: RESEARCH ARTICLE Source Type: research
Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL ‐6
Bisphenol A (BPA) can be accumulated into the human body via food intake and inhalation. Numerous studies indicated that BPA can trigger the tumorigenesis and progression of cancer cells. Laryngeal cancer cells can be exposed to BPA directly via food digestion, while there were very limited data concerning the effect of BPA on the development of laryngeal squamous cell carcinoma (LSCC). Our present study revealed that nanomolar BPA can trigger the proliferation of LSCC cells. Bisphenol A also increased the in vitro migration and invasion of LSCC cells and upregulated the expression of matrix metallopeptidase 2. Among vario...
Source: Cell Biochemistry and Function - April 1, 2017 Category: Biochemistry Authors: Shisheng Li, Bin Wang, Qinglai Tang, Jiajia Liu, Xinming Yang Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - April 1, 2017 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Osteoclast differentiation gene expression profiling reveals chemokine CCL4 mediates RANKL ‐induced osteoclast migration and invasion via PI3K pathway
This study indicated that chemokine CCL4 is an important regulator for OCs migration via PI3K pathway, providing a novel therapy target for bone resorptive diseases. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - March 30, 2017 Category: Biochemistry Authors: Wenhua Xuan, Xiaoke Feng, Chen Qian, Liuying Peng, Yumeng Shi, Lingxiao Xu, Fang Wang, Wenfeng Tan Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - March 8, 2017 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
TRPA1 contributed to the neuropathic pain induced by docetaxel treatment
Peripheral mechanical neuropathic pain is a serious side effect of docetaxel chemotherapy for cancer. However, the underlying mechanism for this side effect is unknown. In the present study, we found that docetaxel treatment induced mechanical allodynia in rats. We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the dorsal root ganglion neurons from the docetaxel treated rats. In addition, application the TRPA1 blocker Ap18 reversed the docetaxel‐induced mechanical hypersensiti...
Source: Cell Biochemistry and Function - March 1, 2017 Category: Biochemistry Authors: Kun Huang, Donglin Bian, Bin Jiang, Qixi Zhai, Ningning Gao, Ruiying Wang Tags: RAPID COMMUNICATION Source Type: research
Differential activities of peroxisomes along the mouse intestinal epithelium
The presence of peroxisomes in mammalian intestine has been revealed formerly by catalase staining combined with electron microscopy. Despite the central role of intestine in lipid uptake and the established importance of peroxisomes in different lipid‐related pathways, few data are available on the physiological role of peroxisomes in intestinal metabolism, more specifically, α‐, β‐oxidation, and etherlipid synthesis. Hence, the peroxisomal compartment was analyzed in more detail in mouse intestine. On the basis of immunohistochemistry, the organelles are mainly confined to the epithelial cells. The expression of ...
Source: Cell Biochemistry and Function - March 1, 2017 Category: Biochemistry Authors: Petruta L. Morvay, Myriam Baes, Paul P. Van Veldhoven Tags: RESEARCH ARTICLE Source Type: research
