Role of the p38 mitogen ‐activated protein kinase signaling pathway in estrogen‐mediated protection following flap ischemia‐reperfusion injury

This study provides an explanation for how estrogen alleviates I/R injury‐induced damage that occurs during skin flap transplantation. In a rat pathological model, I/R injury leads to skin necrosis, skin structure damage, neutrophil infiltration, and inflammatory cytokine secretion, which are probably downstream effects of activation of the p38‐MAPK pathway. On the other hand, estradiol treatment triggers the expression of MAPK phosphatase‐2, a putative phosphatase of p38‐MAPK, and reduced all examined pathological phenomena. Therefore, estrogen may reduce the deleterious effect of I/R injury on skin flap transplantation through modulating the p38‐MAPK pathway.

Source: Cell Biochemistry and Function - October 16, 2016 Category: Biochemistry Authors: JiHui Ju, JianLong Wu, RuiXing Hou Tags: RESEARCH ARTICLE Source Type: research