ZAK β antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα

In this study, we show that the expression of ZAKα activated apoptosis through both a FAS‐dependent pathway and a mitochondria‐dependent pathway by subsequently inducing caspase‐3. ZAKβ, an isoform of ZAKα, is dramatically expressed during cardiac hypertrophy and apoptosis. The interaction between ZAKα and ZAKβ was demonstrated here using immunoprecipitation. The results show that ZAKβ has the ability to diminish the expression level of ZAKα. These findings reveal an inherent regulatory role of ZAKβ to antagonize ZAKα and to subsequently downregulate the cardiac hypertrophy and apoptosis induced by ZAKα.

Source: Cell Biochemistry and Function - November 15, 2016 Category: Biochemistry Authors: Chien ‐Yao Fu, Wei‐Wen Kuo, Tsung‐Jung Ho, Su‐Ying Wen, Ling‐Chun Lin, Yan‐Shen Tseng, Hui‐Chuan Hung, Vijaya Padma Viswanadha, Jaw‐Ji Yang, Chih‐Yang Huang Tags: RESEARCH ARTICLE Source Type: research