Stimulation of the Estrogen Axis Induces Epithelial-Mesenchymal Transition in Human Salivary Cancer cells
Conclusion: These results indicate that hormone therapy used in breast cancer may also be effective for ER-positive SAC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: SUMIDA, T., ISHIKAWA, A., MORI, Y. Tags: Article Source Type: research
Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells
Conclusion: Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: DAGDEMIR, A., JUDES, G., LEBERT, A., ECHEGUT, M., KARSLI-CEPPIOGLU, S., RIFAI, K., DAURES, M., NGOLLO, M., DUBOIS, L., PENAULT-LLORCA, F., BIGNON, Y.-J., BERNARD-GALLON, D. Tags: Article Source Type: research
Expression of microRNAs of C19MC in Different Histological Types of Testicular Germ Cell Tumour
Conclusion: miRNAs of C19MC are overexpressed in more aggressive types of TGCT, suggesting they contribute to malignancy. Furthermore, they might serve as serum biomarkers for these types of TGCT. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: FLOR, I., SPIEKERMANN, M., LONING, T., DIECKMANN, K.-P., BELGE, G., BULLERDIEK, J. Tags: Article Source Type: research
Gene-expression Profiling in Patients with Plasma Cell Myeloma Treated with Novel Agents
Conclusion: In the IMiD-treated groups we found significant changes of expression of angiogenic genes in responders compared to non-responders, whereas in the bortezomib-based group the difference in expression of angiogenic genes was not significant. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: MEDINGER, M., HALTER, J., HEIM, D., BUSER, A., GERULL, S., LENGERKE, C., PASSWEG, J. Tags: Article Source Type: research
Overexpression of HPV16 E6* Alters {beta}-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells
Conclusion: E6* modifies the expression of proteins involved in mitochondrial dysfunction and oxidative phosphorylation in C33A cells, and β-integrin signaling in SiHa cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: EVANS, W., FILIPPOVA, M., FILIPPOV, V., BASHKIROVA, S., ZHANG, G., REEVES, M. E., DUERKSEN-HUGHES, P. Tags: Article Source Type: research
Dissection of the Process of Brain Metastasis Reveals Targets and Mechanisms for Molecular-based Intervention
We describe the process of penetration of the blood-brain-barrier (BBB) by disseminated tumor cells, establishment of a metastatic niche, colonization and outgrowth in the brain parenchyma. Furthermore, the role of angiogenesis in colonization of the brain parenchyma, interactions of extravasated tumor cells with microglia and astrocytes, as well as their propensity for neuromimicry, is discussed. We outline targets suitable for prevention of metastasis and summarize targets suitable for treatment of established brain metastases. Finally, we highlight the implications of findings revealing druggable mutations in brain meta...
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUGER, R. Tags: Article Source Type: research
Does Post-Surgery Placement of Rectus Sheath Block Analgesia Alter the Oxidative Stress Biomarker 8-OHdG Concentrations: A Randomised Trial of Patients with Cancer and Benign Disease
Conclusion: The results suggest that the placement of RSB analgesia does not significantly alter the oxidative stress marker 8-OHdG concentrations in patients with benign disease or cancer patients. A new finding with possible clinical relevance is a significant inverse correlation between the individual plasma values of the hs-CRP and 8-OHdG in patients with benign disease and cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: PURDY, M., KOKKI, M., ANTTILA, M., ASPINEN, S., JUVONEN, P., SELANDER, T., KOKKI, H., PULKKI, K., ESKELINEN, M. Tags: Article Source Type: research
TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing
Conclusion: These results demonstrate that targeted sequencing can reliably identify mutations in individual tumors that make this technology a possibility for clinical use. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: ZHENG, H., WANG, Y., TANG, C., JONES, L., YE, H., ZHANG, G., CAO, W., LI, J., LIU, L., LIU, Z., ZHANG, C., LOU, F., LIU, Z., LI, Y., SHI, Z., ZHANG, J., ZHANG, D., SUN, H., DONG, H., DONG, Z., GUO, B., YAN, H., LU, Q., HUANG, X., CHEN, S.-Y. Tags: Article Source Type: research
Dual Roles of 17-{beta} Estradiol in Estrogen Receptor-dependent Growth Inhibition in Renal Cell Carcinoma
Conclusion: Our data revealed the potential dual roles of E2 in regulating RCC growth via autophagy and apoptosis pathways. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: CHEN, K.-C., LIN, C.-M., HUANG, C.-J., CHEN, S.-K., WU, S.-T., CHIANG, H.-S., KU, W.-C. Tags: Article Source Type: research
SATB1 is Down-regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR-21-5p Overexpression and Poor Prognosis
Conclusion: Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p. Our data suggest that SATB1 may have a potential value as a prognostic marker in ccRCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: KOWALCZYK, A. E., KRAZINSKI, B. E., GODLEWSKI, J., GRZEGRZOLKA, J., KIEWISZ, J., KWIATKOWSKI, P., SLIWINSKA-JEWSIEWICKA, A., DZIEGIEL, P., KMIEC, Z. Tags: Article Source Type: research
Promotion of Cellular Growth and Motility Is Independent of Enzymatic Activity of Fibroblast Activation Protein-{alpha}
Conclusion: Promotion of cellular growth and motility is independent of the enzymatic activity of FAPα in breast cancer cells. The PI3K/AKT and MMP2/9 signaling pathways might be involved in such regulation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: LV, B., XIE, F., ZHAO, P., MA, X., JIANG, W. G., YU, J., ZHANG, X., JIA, J. Tags: Article Source Type: research
Expression of Genes with Copy Number Alterations and Survival of Patients with Pancreatic Adenocarcinoma
Conclusion: Some of these genes can be further investigated as potential prognostic markers. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: BIRNBAUM, D. J., BERTUCCI, F., FINETTI, P., ADELAIDE, J., GIOVANNINI, M., TURRINI, O., DELPERO, J. R., RAOUL, J. L., CHAFFANET, M., MOUTARDIER, V., BIRNBAUM, D., MAMESSIER, E. Tags: Article Source Type: research
The Significance of Proteomic Biomarkers in Male Breast Cancer
Breast cancer in men (MBC) is an uncommon malignancy and accounts for only 1% of all diagnosed breast cancers. By using genomic and transcriptomic approaches, researchers have been able to expand our insight into the genetic basis of breast cancer, by providing new biomarkers. We currently know that gene analysis by itself does not show the complete picture. Along with the genomic approach, proteomics are crucial for the improvement of breast cancer diagnosis, sub-classification, for predicting response to different treatment modalities and for predicting prognosis. There are great challenges in identifying discriminatory ...
Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: ZOGRAFOS, E., GAZOULI, M., TSANGARIS, G., MARINOS, E. Tags: Article Source Type: research
Role of BRAF and RAS Mutations in Extrathyroidal Extension in Papillary Thyroid Cancer
Conclusion: BRAF V600E mutation predisposes PTC cells toward invasive phenotypes, while RAS mutation confers resistance to ETE. The differential regulation appears to be mediated through WNT4. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: PARK, J. Y., YI, J. W., PARK, C. H., LIM, Y., LEE, K. H., LEE, K. E., KIM, J. H. Tags: Article Source Type: research
Doxorubicin Treatment of Cancer Cells Impairs Reverse Transcription and Affects the Interpretation of RT-qPCR Results
Conclusion: DOX may alter the reverse transcription and amplification reactions of RT-qPCR, thus creating a risk of misinterpretation of gene expression results. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: DROZD, E., KRZYSZTOŃ-RUSSJAN, J., GRUBER, B. Tags: Article Source Type: research
