Aberrant Methylation of T-cadherin Can Be a Diagnostic Biomarker for Colorectal Cancer
Conclusion: The methylation status of T-cadherin promoter was strongly associated with CRC risk. However, T-cadherin promoter methylation may have a limited prognostic value for CRC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: DUAN, B.-S., XIE, L.-F., WANG, Y. Tags: Article Source Type: research
Molecular Proteomic Characterization of a Pediatric Medulloblastoma Xenograft
Conclusion: This new xenotransplantable tumor model, offers the scientific community valuable insight on the validity of xenografts altogether, while providing the means for a novel experimental model towards the study of human MBL. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: TSANGARIS, G. T., DIMAS, K., MALAMOU, A., KATSAFADOU, A., PAPATHANASIOU, C., STRAVOPODIS, D. J., VORGIAS, C. E., GAZOULI, M., ANAGNOSTOPOULOS, A. K. Tags: Article Source Type: research
Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins
Conclusion: These novel identified proteins provide the impetus for further functional studies to dissect the mechanisms operating in the two distinct pathways of cervical carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: PAPPA, K. I., LYGIROU, V., KONTOSTATHI, G., ZOIDAKIS, J., MAKRIDAKIS, M., VOUGAS, K., DASKALAKIS, G., POLYZOS, A., ANAGNOU, N. P. Tags: Article Source Type: research
Increased Expression of Follistatin in Breast Cancer Reduces Invasiveness and Clinically Correlates with Better Survival
Conclusion: Our results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: ZABKIEWICZ, C., RESAUL, J., HARGEST, R., JIANG, W. G., YE, L. Tags: Article Source Type: research
Analysis of K-Ras Interactions by Biotin Ligase Tagging
Conclusion: Biotin ligase tagging offers a rapid and convenient approach to the characterization of K-Ras interaction networks. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: RITCHIE, C., MACK, A., HARPER, L., ALFADHLI, A., STORK, P. J. S., NAN, X., BARKLIS, E. Tags: Article Source Type: research
Cytokeratin 18-associated Histone 3 Modulation in Hepatocellular Carcinoma: A Mini Review
Unstable cytokeratins are associated with tumor transformation in the development of human hepatocellular carcinoma. We previously demonstrated that the cytokeratin 18 was modulated and that a histone H3-specific modification occured, among members of the histone family, during the development of human hepatocellular carcinoma. Evidence suggested that the modification of histone H3 was highly correlated with the modulation of cytokeratin 18 and probably plays an important role in tumorigenesis of hepatocytes. Aberrant expression of histone deacetylase leading to imbalance between acetylation and deacetylation of histones m...
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: LAI, Y.-C. C., CHENG, C.-C., LAI, Y.-S., LIU, Y.-H. Tags: Article Source Type: research
The Warburg Effect and Mass Spectrometry-based Proteomic Analysis
Compared to normal cells, cancer cells have a unique metabolism by performing lactic acid fermentation in the presence of oxygen, also known as the Warburg effect. Researchers have proposed several hypotheses to elucidate the phenomenon, but the mechanism is still an enigma. In this review, we discuss three typical models, such as "damaged mitochondria", "adaptation to hypoxia", and "cell proliferation requirement", as well as contributions from mass spectrometry analysis toward our understanding of the Warburg effect. Mass spectrometry analysis supports the "adaptation to hypoxia" model that cancer cells are using quasi-a...
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: ZHOU, W., LIOTTA, L. A., PETRICOIN, E. F. Tags: Article Source Type: research
Proteomics Analysis of Tissue Samples Reveals Changes in Mitochondrial Protein Levels in Parathyroid Hyperplasia over Adenoma
Conclusion: Most proteins found to be over-expressed in the hyperplasia samples were mitochondrial, underlying the importance of the mitochondrial activity as a potential biomarker for differentiation of parathyroid hyperplasia from adenoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 26, 2017 Category: Cancer & Oncology Authors: AKPINAR, G., KASAP, M., CANTURK, N. Z., ZULFIGAROVA, M., ISLEK, E. E., GULER, S. A., SIMSEK, T., CANTURK, Z. Tags: Article Source Type: research
Prognostic Evaluation of Epidermal Growth Factor Receptor (EGFR) Genotype and Phenotype Parameters in Triple-negative Breast Cancers
Conclusion: EGFR gene amplification and mutations are rare in TNBC, the latter of no apparent clinical relevance. Surrogate markers of EGFR-related chromosomal aberrations and combined EGFR/p53 IHC phenotypes appear to be associated with favorable prognosis in patients with operable TNBC receiving conventional adjuvant chemotherapy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 26, 2017 Category: Cancer & Oncology Authors: LEVVA, S., KOTOULA, V., KOSTOPOULOS, I., MANOUSOU, K., PAPADIMITRIOU, C., PAPADOPOULOU, K., LAKIS, S., KOUKOULIAS, K., KARAVASILIS, V., PENTHEROUDAKIS, G., BALASSI, E., ZAGOURI, F., KAKLAMANOS, I. G., PECTASIDES, D., RAZIS, E., ARAVANTINOS, G., PAPAKOSTAS Tags: Article Source Type: research
Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)
Conclusion: We identified a cost-effective, time-saving and reliable methodological approach that could improve the analytical accuracy of the liquid biopsy and appears promising in studying CTCs from cancer patients for both research and clinical purposes. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 26, 2017 Category: Cancer & Oncology Authors: PALMIROTTA, R., LOVERO, D., SILVESTRIS, E., FELICI, C., QUARESMINI, D., CAFFORIO, P., SILVESTRIS, F. Tags: Article Source Type: research
Mining Exosomal Genes for Pancreatic Cancer Targets
Conclusion: The database of exosomal genes established in this study provides a framework for developing novel biomarkers and drug therapy targets for pancreatic cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 26, 2017 Category: Cancer & Oncology Authors: MAKLER, A., NARAYANAN, R. Tags: Article Source Type: research
Long Non-coding RNAs and their Role in Metastasis
The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be uncovered. A large body of evidence has revealed their essential role in all stages of cancirogenesis and metastasis. In this review we focus on the role of lncRNAs in metastasis. We grouped selected lncRNAs into three categories based on in vitro and in vivo mode of action-related studies and clinical relevan...
Source: Cancer Genomics and Proteomics - April 26, 2017 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUGER, R. Tags: Article Source Type: research
Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9
Conclusion: Overexpression of miR-196b may contribute to invasion activities in recurrent EOC by regulating the HOXA9 gene. Moreover, miR-196b can be a potential biomarker in recurrent EOC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: CHONG, G. O., JEON, H.-S., HAN, H. S., SON, J. W., LEE, Y. H., HONG, D. G., PARK, H. J., LEE, Y. S., CHO, Y. L. Tags: Article Source Type: research
Pediatric Ependymoma: A Proteomics Perspective
Conclusion: Through the proposed nanoLC-MS/MS method herein we report, for the firs time, the ependymoma proteome database. A large number of similarities regarding proteome content are revealed compared to other two pediatric brain tumor entities; astrocytomas and medulloblastomas. Furthermore, through our approach, the majority of currently proposed markers for ependymoma (e.g. nucleolin, nestin, Ki67 and laminin subunit A2) as well as all major key players of the phosphoinositide 3-kinase pathway (seemingly implicated in ependymoma), were definitely detected. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: TSANGARIS, G. T., PAPATHANASIOU, C., ADAMOPOULOS, P. G., SCORILAS, A., VORGIAS, C. E., PRODROMOU, N., STATHOPOULOU, F. T., STRAVOPODIS, D. J., ANAGNOSTOPOULOS, A. K. Tags: Article Source Type: research
The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan
Conclusion: The 1G allele of MMP1 promoter 1607 may have a protective effect on HCC risk for non-smokers in Taiwan and further validations are needed in other population groups. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: LAI, Y.-L., GONG, C.-L., FU, C.-K., YUEH, T.-C., TSAI, C.-W., CHANG, W.-S., HSIAO, C.-L., YEN, S.-T., LI, H.-T., JENG, L.-B., WANG, S.-C., BAU, D.-T. Tags: Article Source Type: research
