2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells
Conclusion: Herein, mitochondrial biogenesis pathway regulation and SDHA were presented as novel targets of 2-ME, and moreover, 2-ME was demonstrated as a potent inhibitor of SIRT3. L-lactate was confirmed to exert pro-carcinogenic effects on osteosarcoma cells via the induction of the mitochondrial biogenesis pathway. Thus, L-lactate level may be considered as a prognostic biomarker for osteosarcoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: GORSKA-PONIKOWSKA, M., KUBAN-JANKOWSKA, A., EISLER, S. A., PERRICONE, U., LO BOSCO, G., BARONE, G., NUSSBERGER, S. Tags: Article Source Type: research
Genetic Variations in the 3-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk
Conclusion: PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: ZHANG, Q., WANG, W., XU, W., DU, M., MA, G., LIU, H., CHU, H., TONG, N., WANG, M., SHAO, J., ZHANG, Z., YUAN, L., QIAN, J. Tags: Article Source Type: research
Consistent Involvement of Chromosome 13 in Angiolipoma
Conclusion: Chromosome 13 was consistently involved in all three angiolipomas. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., ANDERSEN, K., LOBMAIER, I., BJERKEHAGEN, B., HEIM, S. Tags: Article Source Type: research
Regulation of {beta}-Catenin Phosphorylation by PR55{beta} in Adenoid Cystic Carcinoma
Conclusion: Our study provides new insight into the interaction between PR55β and β-catenin and suggests that PR55β may be a target for the clinical treatment of AdCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: ISHIBASHI, K., ISHII, K., SUGIYAMA, G., KAMATA, Y., SUZUKI, A., KUMAMARU, W., OHYAMA, Y., NAKANO, H., KIYOSHIMA, T., SUMIDA, T., YAMADA, T., MORI, Y. Tags: Article Source Type: research
Applications of Support Vector Machine (SVM) Learning in Cancer Genomics
Machine learning with maximization (support) of separating margin (vector), called support vector machine (SVM) learning, is a powerful classification tool that has been used for cancer genomic classification or subtyping. Today, as advancements in high-throughput technologies lead to production of large amounts of genomic and epigenomic data, the classification feature of SVMs is expanding its use in cancer genomics, leading to the discovery of new biomarkers, new drug targets, and a better understanding of cancer driver genes. Herein we reviewed the recent progress of SVMs in cancer genomic studies. We intend to comprehe...
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: HUANG, S., CAI, N., PACHECO, P. P., NARANDES, S., WANG, Y., XU, W. Tags: Article Source Type: research
The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets
We present an overview on metastasis-promoting, -suppressing and context-dependent miRs with both activities. We have categorized the corresponding miRs according to their target classes, interaction with stromal cells or exosomes. The pathways affected by individual miRs are outlined in regard to in vitro properties, activity in metastasis-related in vivo models and clinical significance. Current approaches that may be suitable for therapeutic inhibition or restauration of miR activity are outlined. Finally, we discuss the delivery bottlenecks which present as a major challenge in nucleic acid (miR)-based therapies. (Sour...
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: WEIDLE, U. H., DICKOPF, S., HINTERMAIR, C., KOLLMORGEN, G., BIRZELE, F., BRINKMANN, U. Tags: Article Source Type: research
Potential microRNA-related Targets for Therapeutic Intervention with Ovarian Cancer Metastasis
Treatment of disseminated epithelial ovarian cancer (EOC) is an unmet medical need. Therefore, the identification along with preclinical and clinical validation of new targets is an issue of high importance. In this review we focus on microRNAs that mediate metastasis of EOC. We summarize up-regulated metastasis-promoting and down-regulated metastasis-suppressing microRNAs. We focus on preclinical in vitro and in vivo functions as well as their metastasis-related clinical correlations. Finally, we outline modalities for therapeutic intervention and critical issues of microRNA-based therapeutics in the context of metastatic...
Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., NOPORA, A. Tags: Article Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Tags: Index Source Type: research
High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases
Conclusion: High resolution proteomics analysis of cervical cancer secretome revealed significantly deregulated biological processes and proteins implicated in cervical carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: PAPPA, K. I., KONTOSTATHI, G., MAKRIDAKIS, M., LYGIROU, V., ZOIDAKIS, J., DASKALAKIS, G., ANAGNOU, N. P. Tags: Reviews Source Type: research
Targeted Gene Sequencing of Gallbladder Carcinoma Identifies High-impact Somatic and Rare Germline Mutations
Conclusion: Our results indicated the significance of inherited rare germline mutations in DNA-repair pathway genes in addition to acquired somatic mutations in GB carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: YADAV, S., DE SARKAR, N., KUMARI, N., KRISHNANI, N., KUMAR, A., MITTAL, B. Tags: Reviews Source Type: research
2-Methoxyestradiol Reverses the Pro-Carcinogenic Effect of L-Lactate in Osteosarcoma 143B Cells
Conclusion: 2-Methoxyestradiol is a potent anticancer agent also under metabolic reprogramming conditions. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: GORSKA-PONIKOWSKA, M., KUBAN-JANKOWSKA, A., DACA, A., NUSSBERGER, S. Tags: Reviews Source Type: research
Role of Melt Curve Analysis in Interpretation of Nutrigenomics' MicroRNA Expression Data
This article illustrates the importance of melt curve analysis (MCA) in interpretation of mild nutrogenomic micro(mi)RNA expression data, by measuring the magnitude of the expression of key miRNA molecules in stool of healthy human adults as molecular markers, following the intake of Pomegranate juice (PGJ), functional fermented sobya (FS), rich in potential probiotic lactobacilli, or their combination. Total small RNA was isolated from stool of 25 volunteers before and following a three-week dietary intervention trial. Expression of 88 miRNA genes was evaluated using Qiagen's 96 well plate RT2 miRNA qPCR arrays. Employing...
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: AHMED, F. E., GOUDA, M. M., HUSSEIN, L. A., AHMED, N. C., VOS, P. W., MOHAMMAD, M. A. Tags: Reviews Source Type: research
DHPLC Elution Patterns of VDR PCR Products Can Predict Prostate Cancer Susceptibility in African American Men
Conclusion: DHPLC elution patterns of the selected exons could be useful to predict susceptibility to develop PCa. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: COPELAND, R. L., BEYENE, D., APPREY, V., DAREMIPOURAN, M. R., NAAB, T. J., KASSIM, O. O., KANAAN, Y. M. Tags: Reviews Source Type: research
The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis
Conclusion: The FEN1 rs174538 A allele is a novel protective biomarker for endometriosis and this genotype may have interactions with age- and hormone-related factors on the development of endometriosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: CHOU, A.-K., SHEN, M.-Y., CHEN, F.-Y., HSIAO, C.-L., SHIH, L.-C., CHANG, W.-S., TSAI, C.-W., YING, T.-H., WU, M.-H., HUANG, C.-Y., BAU, D.-T. Tags: Reviews Source Type: research
CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma
Conclusion: CYP3A4 was identified as a novel tumor suppressor gene related to a poor prognosis in HCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: ASHIDA, R., OKAMURA, Y., OHSHIMA, K., KAKUDA, Y., UESAKA, K., SUGIURA, T., ITO, T., YAMAMOTO, Y., SUGINO, T., URAKAMI, K., KUSUHARA, M., YAMAGUCHI, K. Tags: Reviews Source Type: research
