A Comparative Study of the Molecular Characteristics of Familial Gliomas and Other Cancers
Conclusion: Familial cancers are likely driven by multiple, individually weak contributions to familiality (i.e. large numbers of alleles and/or shared environmental risks). Consequently, these risk factors tend to be obscured by stronger confounding variables such as clinical or molecular variation among cancer subtypes. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: LU, J., BURNETT, M. G., SHPAK, M. Tags: Article Source Type: research
In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue
Conclusion: Label-free MS-based proteomics is useful for analyzing FFPE cSCC tissues. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: AZIMI, A., KAUFMAN, K. L., ALI, M., KOSSARD, S., FERNANDEZ-PENAS, P. Tags: Article Source Type: research
Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells
Conclusion: Part of HSPGs in glioma cells is internalized through clathrin-dependent endocytosis and undergo recycling. The development of compounds regulating HSPG-mediated trafficking will likely enable design of effective glioma treatment. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: PODYMA-INOUE, K. A., MORIWAKI, T., RAJAPAKSHE, A. R., TERASAWA, K., HARA-YOKOYAMA, M. Tags: Article Source Type: research
Differential Expression of Ccn4 and Other Genes Between Metastatic and Non-metastatic EL4 Mouse Lymphoma Cells
Conclusion: The results provide insights into signaling pathways potentially involved in conferring metastatic ability on lymphoma cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: CHAHAL, M. S., KU, H. T., ZHANG, Z., LEGASPI, C. M., LUO, A., HOPKINS, M. M., MEIER, K. E. Tags: Article Source Type: research
Clinical and Therapeutic Implications of Follistatin in Solid Tumours
Follistatin (FST), as a single-chain glycosylated protein, has two major isoforms, FST288 and FST315. The FST315 isoform is the predominant form whilst the FST288 variant accounts for less than 5% of the encoded mRNA. FST is differentially expressed in human tissues and aberrant expression has been observed in a variety of solid tumours, including gonadal, gastric and lung cancer, hepatocellular carcinoma, basal cell carcinoma and melanoma. Based on the current evidence, FST is an antagonist of transforming growth factor beta family members, such as activin and bone morphogenetic proteins (BMPs). FST plays a role in tumour...
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: SHI, L., RESAUL, J., OWEN, S., YE, L., JIANG, W. G. Tags: Article Source Type: research
Mechanisms and Targets Involved in Dissemination of Ovarian Cancer
Ovarian carcinoma is associated with the highest death rate of all gynecological tumors. On one hand, its aggressiveness is based on the rapid dissemination of ovarian cancer cells to the peritoneum, the omentum, and organs located in the peritoneal cavity, and on the other hand, on the rapid development of resistance to chemotherapeutic agents. In this review, we focus on the metastatic process of ovarian cancer, which involves dissemination of, homing to and growth of tumor cells in distant organs, and describe promising molecular targets for possible therapeutic intervention. We provide an outline of the interaction of ...
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUEGER, R. Tags: Article Source Type: research
Enhancement of Pathologist's Routine Practice: Reuse of DNA Extracted from Immunostained Formalin-fixed Paraffin-embedded (FFPE) Slides in Downstream Molecular Analysis of Cancer
Conclusion: This study is a proof of concept to recycle and reuse DNA from IHC stained slides with suitable concentration and integrity for further downstream molecular applications. These findings will enhance the pathologists' knowledge, attitudes and practices (KAP) towards the use of these biospecimens and support the implementation of this approach in clinical pathology practice. Therefore, the scientific community will benefit from the largest comprehensive database of human fully annotated FFPE biospecimens already available at their disposal in order to demystify the complexity and the heterogeneity of many challen...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: AL-ATTAS, A., ASSIDI, M., AL-MAGHRABI, J., DALLOL, A., SCHULTEN, H.-J., ABU-ELMAGD, M., CHAUDHARY, A., ABUZENADAH, A., BUDOWLE, B., BUHMEIDA, A., AL-QAHTANI, M. Tags: Article Source Type: research
Elevated O-GlcNAcylation of Extracellular Vesicle Proteins Derived from Metastatic Colorectal Cancer Cells
Conclusion: These data, demonstrate that proteins carried by EVs are O-GlcNAc-modified. Importantly, elevated aberrant O-GlcNAcylation of EV proteins might serve as a potential biomarker of metastatic CRC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: CHAIYAWAT, P., WEERAPHAN, C., NETSIRISAWAN, P., CHOKCHAICHAMNANKIT, D., SRISOMSAP, C., SVASTI, J., CHAMPATTANACHAI, V. Tags: Article Source Type: research
A Sensitive Peptide Nucleic Acid Probe Assay for Detection of BRAF V600 Mutations in Melanoma
Mutated v-Raf murine sarcoma viral oncogene homolog B (BRAF) is an important biomarker for the prediction of therapeutic efficacy of several anticancer drugs. The detection of BRAF mutation faces two challenges: Firstly, there are multiple types of mutations, and secondly, tumor samples usually contain various amounts of wild-type, normal tissues. Here, we describe a newly established method for sensitive detection of multiple types of BRAF V600 mutations in excess wild-type background. The method introduced a fluorophore-tagged peptide nucleic acid (PNA) to serve as both polymerase chain reaction (PCR) clamp and sensor pr...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: CHEN, T.-L., CHANG, J. W.-C., HSIEH, J.-J., CHENG, H.-Y., CHIOU, C.-C. Tags: Article Source Type: research
Meningiomas and Proteomics: Focus on New Potential Biomarkers and Molecular Pathways
This article provides an overview of the current literature regarding the molecular aspect of meningiomas. Analysis of potential biomarkers in serum, cerebrospinal fluid (CSF) and pathological tissues was reported. Applying bioinformatic methods and matching the common proteic profile, arising from different biological samples, we highlighted the role of nine proteins, particularly related to tumorigenesis and grading of meningiomas: serpin peptidase inhibitor alpha 1, ceruloplasmin, hemopexin, albumin, C3, apolipoprotein, haptoglobin, amyloid-P-component serum and alpha-1-beta-glycoprotein. These proteins and their associ...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: ABBRITTI, R. V., POLITO, F., CUCINOTTA, M., LO GIUDICE, C., CAFFO, M., TOMASELLO, C., GERMANO, A., AGUENNOUZ, M. Tags: Article Source Type: research
EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells
Erythropoietin-producing hepatocellular carcinoma cell (EPH) receptors comprise the most abundant receptor tyrosine kinase family characterized to date in mammals including humans. These proteins are involved in axon guidance, tissue organization, vascular development and the intricate process of various diseases including cancer. These diverse functions of EPH receptors are attributed, in part, to their abilities for heterodimerization. While the interacting partners of kinase-deficient EPHB6 receptor have been characterized, the interaction of the kinase-dead EPHA10 with any other receptor has not been identified. By usi...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: JOHNSON, C., SEGOVIA, B., KANDPAL, R. P. Tags: Article Source Type: research
Phospho-Network Analysis Identifies and Quantifies Hepatitis C Virus (HCV)-induced Hepatocellular Carcinoma (HCC) Proteins Regulating Viral-mediated Tumor Growth
Conclusion: This function-focused workflow provides a simple framework to analyze MS data. Phosphoproteome quantitation with inclusive functional analysis can generate hypotheses for liver cancer research to improve early screening and identification of molecular targets for therapy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: LU, N. T., LIU, N. M., VU, J. Q., PATEL, D., COHN, W., CAPRI, J., ZIEGLER, M., PATEL, N., TRAMONTANO, A., WILLIAMS, R., WHITELEGGE, J., FRENCH, S. W. Tags: Article Source Type: research
Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity
Our research team has recently isolated and characterized a new stromal stem cell line (hUCESCs) obtained from cytological smears, as routinely performed for cervical cancer screening. We have, furthermore, described that both hUCESCs directly, as well as the secretome contained in the conditioned medium used for growing them (hUCESCs-CM) have potent antitumoral, anti-inflammatory, antibiotic, antimycotic and re-epitheliasation-enhancing properties. The scientific explanation our team proposes for these pleiotropic effects are directly related to the site of origin of hUCESCs, the human cervical transition zone, which has ...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: SCHNEIDER, J., EIRO, N., PEREZ-FERNANDEZ, R., MARTINEZ-ORDONEZ, A., VIZOSO, F. Tags: Article Source Type: research
Novel Prognostic and Therapeutic Mutations in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically heterogeneous disease, and its incidence increases with age. Cytogenetics and mutation testing remain important prognostic tools for treatment after induction therapy. The post-induction treatment is dependent on risk stratification. Despite rapid advances in determination of gene mutations involved in the pathophysiology and biology of AML, and the rapid development of new drugs, treatment improvements changed slowly over the past 30 years, with the majority of patients eventually experiencing relapse and dying of their disease. Allogeni...
Source: Cancer Genomics and Proteomics - August 25, 2016 Category: Cancer & Oncology Authors: MEDINGER, M., LENGERKE, C., PASSWEG, J. Tags: Article Source Type: research
Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer
Conclusion: These results indicate that miRNAs could serve as new therapeutic targets in patients with metastatic CRC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 29, 2016 Category: Cancer & Oncology Authors: VYCHYTILOVA-FALTEJSKOVA, P., PESTA, M., RADOVA, L., LISKA, V., DAUM, O., KALA, Z., SVOBODA, M., KISS, I., SLABY, O. Tags: Article Source Type: research
