A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ
Conclusion: The MM cell secretome is enriched in proteins that are likely to enhance its growth and response to stress and help it inhibit an adaptive immune response. These are potential targets for therapeutic and biomarker discovery. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: CREANEY, J., DICK, I. M., LEON, J. S., ROBINSON, B. W. S. Tags: Article Source Type: research
Monochromosomal Hybrids and Chromosome Transfer: A Functional Approach for Gene Identification
Functional complementation of cellular defects has been a valuable approach for localizing causative genes to specific chromosomes. The complementation strategy was followed by positional cloning and characterization of genes for their biological relevance. We herein describe strategies used for the construction of monochromosomal hybrids and their applications for cloning and characterization of genes related to cell growth, cell senescence and DNA repair. We have cloned RNaseT2, GluR6 (glutamate ionotropic receptor kainate type subunit 2-GRIK2) and protein tyrosine phosphatase, receptor type K (PTPRK) genes using these s...
Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: KANDPAL, R. P., SANDHU, A. K., KAUR, G., KAUR, G. P., ATHWAL, R. S. Tags: Article Source Type: research
Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line
Conclusion: These results suggest that the STAT3 pathway is associated with the mTOR downstream pathway mediated by YKL-40 protein, and the combination therapy of the STAT3 inhibitor and rapamycin could be worth developing as a novel therapeutic approach against TMZ-resistant relapsed gliomas. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: MIYATA, H., ASHIZAWA, T., IIZUKA, A., KONDOU, R., NONOMURA, C., SUGINO, T., URAKAMI, K., ASAI, A., HAYASHI, N., MITSUYA, K., NAKASU, Y., YAMAGUCHI, K., AKIYAMA, Y. Tags: Article Source Type: research
MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis
Conclusion: miR-142-3p, miR-155 and miR-203 expression levels might be helpful biomarkers for the differential diagnosis between gastric MALT lymphomas and chronic gastritis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: FERNANDEZ, C., BELLOSILLO, B., FERRARO, M., SEOANE, A., SANCHEZ-GONZALEZ, B., PAIRET, S., PONS, A., BARRANCO, L., VELA, M. C., GIMENO, E., COLOMO, L., BESSES, C., NAVARRO, A., SALAR, A. Tags: Article Source Type: research
Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues
Conclusion: In our preliminary studies using high-resolution custom microarray we confirmed that PTPs are frequently subjected to whole-gene rearrangements in colorectal cancer, and we revealed that non-polymorphic intragenic changes are rare. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: LACZMANSKA, I., SKIBA, P., KARPINSKI, P., BEBENEK, M., SASIADEK, M. M. Tags: Article Source Type: research
Expression Profiling of a Human Thyroid Cell Line Stably Expressing the BRAFV600E Mutation
Conclusion: Our Nthy/WT and Nthy/V600E cell line pair could be a suitable model to study the molecular characteristics of BRAFV600E PTC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: KIM, B.-A., JEE, H.-G., YI, J. W., KIM, S.-J., CHAI, Y. J., CHOI, J. Y., LEE, K. E. Tags: Article Source Type: research
Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins
Conclusion: Proteomics combined with pathway analysis provided information for an effective combined treatment approach overcoming drug resistance. Analysis of cell lines and tissues revealed potential prognostic biomarkers for ovarian cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: CRUZ, I. N., COLEY, H. M., KRAMER, H. B., MADHURI, T. K., SAFUWAN, N. A. M., ANGELINO, A. R., YANG, M. Tags: Article Source Type: research
HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells
Conclusion: The data from this study show that plant- based HDACis are relatively rare, and can elicit a similar pattern to TSA in up-regulating miRNAs involved with tumor suppression of HeLa cervical carcinoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: MAZZIO, E. A., SOLIMAN, K. F. A. Tags: Article Source Type: research
The Multiple Roles of Exosomes in Metastasis
Exosomes are important contributors to cell–cell communication and their role as diagnostic markers for cancer and the pathogenesis for cancer is under intensive investigation. Here, we focus on their role in metastasis-related processes. We discuss their impact regarding promotion of invasion and migration of tumor cells, conditioning of lymph nodes, generation of premetastatic niches and organotropism of metastasis. Furthermore, we highlight interactions of exosomes with bone marrow and stromal components such as fibroblasts, endothelial cells, myeloid- and other immune-related cells in the context of metastases. F...
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUGER, R. Tags: Article Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Tags: Article Source Type: research
Platelet Derived Growth Factor BB: A "Must-have" Therapeutic Target "Redivivus" in Ovarian Cancer
Conclusion: Dual PDGF-BB expression in tumor and stromal cells have been observed, being highly suggestive for PDGF-BB mediated stromal-tumor cells reciprocal interaction in ovarian cancer (p=0.008). It seems that the nuclear expression of the PDGF-BB represents a negative prognostic factor in ovarian tumors. Being a controversial issue in the literature, PDGF-BB nuclear expression detected by immunohistochemistry was validated by RNAscope in situ hybridization. More than 65% of cases had PDGF-BB mRNA amplification, confirming immunohistochemical results. We herein validated PDGF-BB as a potential therapeutic and prognosti...
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: CIMPEAN, A. M., COBEC, I. M., CEAUSU, R. A., POPESCU, R., TUDOR, A., RAICA, M. Tags: Article Source Type: research
Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals
Conclusion: Our data would suggest a JCPyV involvement in cancer progression and a BKPyV association with BC pathogenesis in immunocompetent patients. However, further work is necessary to better understand the exact role of PyVs in urothelial carcinogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: ANZIVINO, E., ZINGAROPOLI, M. A., IANNETTA, M., PIETROPAOLO, V. A., OLIVA, A., IORI, F., CIARDI, A., RODIO, D. M., ANTONINI, F., FEDELE, C. G., D'ABRAMO, A., MASTROIANNI, C. M., VULLO, V., CIARDI, M. R. Tags: Article Source Type: research
Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis
Conclusion: ID2 expression triggered a malignant phenotype, especially of invasive properties, through the ID2–SNAIL axis. Thus, ID2 represents a potential therapeutic target for OSCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: KAMATA, Y., SUMIDA, T., KOBAYASHI, Y., ISHIKAWA, A., KUMAMARU, W., MORI, Y. Tags: Article Source Type: research
Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer
Conclusion: Differences in patterns of methylation of the hTERT core promoter [region 1 (nt -208 to -1) and region 2 (nt +1 to +104) relative to first ATG] are related to the HPV species present. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: MOLANO, M., MORENO-ACOSTA, P., MORALES, N., BURGOS, M., BUITRAGO, L., GAMBOA, O., ALVAREZ, R., GARLAND, S. M., TABRIZI, S. N., STEENBERGEN, R. D. M., MEJIA, J. C. Tags: Article Source Type: research
Association of BIM Deletion Polymorphism and BIM-{gamma} RNA Expression in NSCLC with EGFR Mutation
Conclusion: Expression of BIM- mRNA and BIM deletion polymorphism were strongly associated. BIM- overexpression may have a role in apoptosis related to EGFR-tyrosine kinase inhibitor. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 1, 2016 Category: Cancer & Oncology Authors: ISOBE, K., KAKIMOTO, A., MIKAMI, T., KABURAKI, K., KOBAYASHI, H., YOSHIZAWA, T., MAKINO, T., OTSUKA, H., SANO, G., SUGINO, K., SAKAMOTO, S., TAKAI, Y., TOCHIGI, N., IYODA, A., HOMMA, S. Tags: Article Source Type: research
