Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells
Conclusion: These results indicate involvement of GRIK2 in senescence and suggests GRIK2 as a potential target for therapeutic intervention of cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: ZHAWAR, V. K., KANDPAL, R. P., ATHWAL, R. S. Tags: Article Source Type: research
Human Periprostatic Adipose Tissue: Secretome from Patients With Prostate Cancer or Benign Prostate Hyperplasia
Conclusion: Proteins and pathways reported in this study could be useful to distinguish stages of disease and may become targets for novel therapies. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: SACCA, P. A., MAZZA, O. N., SCORTICATI, C., VITAGLIANO, G., CASAS, G., CALVO, J. C. Tags: Article Source Type: research
Multiregion Genomic Analysis of Serially Transplanted Patient-derived Xenograft Tumors
Conclusion: PDX-MRA is a useful tool for understanding the spatiotemporal dynamics of ITH. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: SATO, K., NIIDA, A., MASUDA, T., SHIMIZU, D., TOBO, T., KURODA, Y., EGUCHI, H., NAKAGAWA, T., SUZUKI, Y., MIMORI, K. Tags: Article Source Type: research
The Functional Role of Prostate Cancer Metastasis-related Micro-RNAs
The mortality of patients with hormone-resistant prostate cancer can be ascribed to a large degree to metastasis to distant organs, predominantly to the bones. In this review, we discuss the contribution of micro-RNAs (miRs) to the metastatic process of prostate cancer. The criteria for selection of miRs for this review were the availability of preclinical in vivo metastasis-related data in conjunction with prognostic clinical data. Depending on their function in the metastatic process, the corresponding miRs are up- or down-regulated in prostate cancer tissues when compared to matching normal tissues. Up-regulated miRs pr...
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: WEIDLE, U. H., EPP, A., BIRZELE, F., BRINKMANN, U. Tags: Article Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Tags: Index Source Type: research
NOTUM Is Involved in the Progression of Colorectal Cancer
Conclusion: NOTUM may be a new candidate for diagnostics and therapy of CRC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: YOON, J. H., KIM, D., KIM, J., LEE, H., GHIM, J., KANG, B. J., SONG, P., SUH, P.-G., RYU, S. H., LEE, T. G. Tags: Article Source Type: research
Tumor Susceptibility Gene 101 Mediates Anoikis Resistance of Metastatic Thyroid Cancer Cells
Conclusion: To our knowledge, this is the first study that implicates the importance of TSG101 in anoikis resistance of thyroid cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: SAHARAT, K., LIRDPRAPAMONGKOL, K., CHOKCHAICHAMNANKIT, D., SRISOMSAP, C., SVASTI, J., PARICHARTTANAKUL, N. M. Tags: Article Source Type: research
Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab
Conclusion: This study revealed a crosstalk between the IGF-R pathway and HER2. There was evidence that high Akt1 and GLP-1R mRNA expression might affect survival among HER2-positive metastatic breast cancer patients treated with trastuzumab. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: CHRISTODOULOU, C., OIKONOMOPOULOS, G., KOLIOU, G. A., KOSTOPOULOS, I., KOTOULA, V., BOBOS, M., PENTHEROUDAKIS, G., LAZARIDIS, G., SKONDRA, M., CHRISAFI, S., KOUTRAS, A., BAFALOUKOS, D., RAZIS, E., PAPADOPOULOU, K., PAPAKOSTAS, P., KALOFONOS, H. P., PECTAS Tags: Article Source Type: research
Novel Combination of Arsenic Trioxide (As2O3) Plus Resveratrol in Inducing Programmed Cell Death of Human Neuroblastoma SK-N-SH Cells
Conclusion: Combined treatment at extremely low concentration of two agents from natural products, As2O3 and resveratrol, has high potential as a cocktail of anticancer drugs for neuroblastoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: YEN, C.-M., TSAI, C.-W., CHANG, W.-S., YANG, Y.-C., HUNG, Y.-W., LEE, H.-T., SHEN, C.-C., SHEU, M.-L., WANG, J.-Y., GONG, C.-L., CHENG, W.-Y., BAU, D.-T. Tags: Article Source Type: research
mRNA Expression of CDK2AP1 in Human Breast Cancer: Correlation with Clinical and Pathological Parameters
Conclusion: To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer over a long-term follow-up period. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: GERA, R., MOKBEL, L., JIANG, W. G., MOKBEL, K. Tags: Article Source Type: research
MGMT Gene Promoter Methylation Status - Assessment of Two Pyrosequencing Kits and Three Methylation-specific PCR Methods for their Predictive Capacity in Glioblastomas
Conclusion: PSQ is the method of choice for MGMT promoter methylation analysis in routine clinical practice. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: JOHANNESSEN, L. E., BRANDAL, P., MYKLEBUST, T. A., HEIM, S., MICCI, F., PANAGOPOULOS, I. Tags: Article Source Type: research
Bridging Cancer Biology with the Clinic: Comprehending and Exploiting IDH Gene Mutations in Gliomas
Isocitrate dehydrogenases 1 and 2 (IDH1/2) are enzymes that play a major role in the Krebs cycle. Mutations in these enzymes are found in the majority of lower gliomas and secondary glioblastomas, but also in myeloid malignancies and other cancers. IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic enzyme activity resulting in the accumulation of D-2-hydroxyglutarate (2-HG). 2-HG is an oncometabolite causing profound metabolic dysregulation which, among others, results in methylator phenotypes and in defects in homol...
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: ROMANIDOU, O., KOTOULA, V., FOUNTZILAS, G. Tags: Article Source Type: research
Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma
Conclusion: Target genes of the LMO1-regulated microRNAs and their relevant pathways may be a potential therapeutic target. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: SAEKI, N., SAITO, A., SUGAYA, Y., AMEMIYA, M., SASAKI, H. Tags: Article Source Type: research
Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan
Conclusion: The genotypes of MDM2 SNP309 may allow forr early detection of and predictor for CRC risk, especially among smokers and non-alcohol drinkers, but not for prognosis. The combined effects of MDM2 SNP309 and other genes (such as matrix metalloproteinases) on CRC susceptibility and prognosis, should also be taken into consideration in the era of precision medicine. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: YUEH, T.-C., HUNG, Y.-W., SHIH, T.-C., WU, C.-N., WANG, S.-C., LAI, Y.-L., HSU, S.-W., WU, M.-H., FU, C.-K., WANG, Y.-C., KE, T.-W., CHANG, W.-S., TSAI, C.-W., BAU, D.-T. Tags: Article Source Type: research
Pull-down Assay on Streptavidin Beads and Surface Plasmon Resonance Chips for SWATH-MS-based Interactomics
Conclusion: Our study supports further application of SPR-based affinity purification with SWATH mass spectrometry for reproducible and controlled characterization of cancer-associated interactomes. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: MARYAŠ, J., FAKTOR, J., ČAPKOVA, L., MULLER, P., SKLADAL, P., BOUCHAL, P. Tags: Article Source Type: research
