Fusion of the COL1A1 and FYN Genes in Epithelioid Osteoblastoma
Conclusion: A COL1A1-FYN fusion gene was found in an epithelioid osteoblastoma resulting in deregulation of FYN. Whether COL1A1-FYN represents a consistent genetic feature of epithelioid osteoblastomas, remains to be seen. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LOBMAIER, I., LUND-IVERSEN, M., ANDERSEN, K., HOLTH, A., BJERKEHAGEN, B., HEIM, S. Tags: Article Source Type: research
MiR-376b-3p Is Associated With Long-term Response to Sunitinib in Metastatic Renal Cell Carcinoma Patients
Conclusion: A predictive miRNA associated with progression-free survival in metastatic renal cell carcinoma patients treated with sunitinib was identified. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: KOVACOVA, J., JURACEK, J., POPRACH, A., KOPECKY, J., FIALA, O., SVOBODA, M., FABIAN, P., RADOVA, L., BRABEC, P., BUCHLER, T., SLABY, O. Tags: Article Source Type: research
Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma
Conclusion: Malignant chondroid syringoma is genetically related to tumors with PHF1 rearrangements such as low-grade endometrial sarcoma and ossifying fibromyxoid tumor, but also with tumors having TFE3 rearrangements such as renal cell carcinoma, alveolar soft part sarcoma, PEComa, and epithelioid hemangioendothelioma. Further investigations on malignant chondroid syringomas are needed in order to determine whether genetic heterogeneity exists among them and the clinical impact of the PHF1-TFE3 fusion. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LUND-IVERSEN, M., BASSAROVA, A., HEIM, S. Tags: Article Source Type: research
Association of Leukemia Target Genes Tet2, Bcl2, and Slc23a2 in Vitamin C Pathways
In conclusion, Alternative pathways and key genes that connect Tet2, Bcl2, and Slc23a2 for their therapeutic applications with vitamin C were identified. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: LI, J., ZHANG, W., LIU, W., RONG, J., CHEN, Y., GU, W., ZHANG, W. Tags: Article Source Type: research
Co-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells
Conclusion: This study provides a proteomic platform for investigating the paracrine role of CAA in promoting breast cancer cell metastasis and resistance to therapy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: LEE ISLA CRAKE, R., PHILLIPS, E., KLEFFMANN, T., CURRIE, M. J. Tags: Article Source Type: research
EPB41L5 is Associated With the Metastatic Potential of Low-grade Pancreatic Neuroendocrine Tumors
Conclusion: These results support further investigation into whether EPB41L5 is a biomarker of PNETs with high risk for metastases. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: SALLER, J., SEYDAFKAN, S., SHAHID, M., GADARA, M., CIVES, M., ESCHRICH, S. A., BOULWARE, D., STROSBERG, J. R., AEJAZ, N., COPPOLA, D. Tags: Article Source Type: research
Intracellular Chloride Ion Channel Protein-1 Expression in Clear Cell Renal Cell Carcinoma
Conclusion: We defined four cc RCC groups depending on G, CLIC1 expression and pattern: i) G3/NM/low CLIC1+, ii) G2/CM/mild CLIC1+ iii) G1 or G2/NM or CM /high CLIC1+, and iv) G2/M /high CLIC1+. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: NESIU, A., CIMPEAN, A. M., CEAUSU, R. A., ADILE, A., IOIART, I., PORTA, C., MAZZANTI, M., CAMEROTA, T. C., RAICA, M. Tags: Article Source Type: research
Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma
Conclusion: FOSB may be fused with SERPINE1, ACTB, or WWTR1 in pseudomyogenic hemangioendotheliomas. The resulting overexpression of FOSB fusion is a potentially useful marker that could be helpful in the diagnosis of these tumors. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., LOBMAIER, I., GORUNOVA, L., HEIM, S. Tags: Article Source Type: research
Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan
Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: HSU, S.-W., GONG, C.-L., HSU, H.-M., CHAO, C.-C., WANG, Y.-C., CHANG, W.-S., TSAI, Y.-T., SHIH, L.-C., TSAI, C.-W., BAU, D.-T. Tags: Article Source Type: research
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics
Conclusion: Altered mutant peptides present in PCa tissue could be used as new biomarkers in advanced PCa. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: KWON, O. K., HA, Y.-S., LEE, J. N., KIM, S., LEE, H., CHUN, S. Y., KWON, T. G., LEE, S. Tags: Article Source Type: research
STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon
Conclusion: We report a novel mutation STK11 (p.G270W), in medullary carcinoma of the colon with an associated mucinous component. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: SHAHID, M., WANG, D., SALLER, J., RYZHOVA, E., QIN, D., MAGLIOCCO, A., COPPOLA, D. Tags: Article Source Type: research
Gene Expression Profiles Induced by High-dose Ionizing Radiation in MDA-MB-231 Triple-negative Breast Cancer Cell Line
Conclusion: In summary, our data highlight, the RT response of TNBC MDA-MB-231 cell line at a transcriptional level, in terms of activating radioresistance in these cells, as a model of late-stage BC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: BRAVATA, V., CAMMARATA, F. P., MINAFRA, L., MUSSO, R., PUCCI, G., SPADA, M., FAZIO, I., RUSSO, G., FORTE, G. I. Tags: Article Source Type: research
The Association of a Novel Identified VDR SNP With Prostate Cancer in African American Men
Conclusion: SNP 4 and SNP 7 could be promising markers for prediction of reduced or increased prostate cancer risk, respectively. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: DAREMIPOURAN, M. R., BEYENE, D., APPREY, V., NAAB, T. J., KASSIM, O. O., COPELAND, R. L., KANAAN, Y. M. Tags: Article Source Type: research
Diagnosis of Non-small Cell Lung Cancer for Early Stage Asymptomatic Patients
Conclusion: A specific, non-invasive, early-detection test, in combination with low-dose computed tomography, could increase survival rates and reduce false positives from screenings. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 25, 2019 Category: Cancer & Oncology Authors: GOEBEL, C., LOUDEN, C. L., MCKENNA, R., ONUGHA, O., WACHTEL, A., LONG, T. Tags: Article Source Type: research
Pathogenic and Targetable Genetic Alterations in Resected Recurrent Undifferentiated Pleomorphic Sarcomas Identified by Targeted Next-generation Sequencing
Conclusion: Routine use of targeted next-generation sequencing for recurrent UPS can facilitate timely therapeutic decision-making. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: ZHENG, B., QU, Y., WANG, J., SHI, Y., YAN, W. Tags: Article Source Type: research
