Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma

Conclusion: Malignant chondroid syringoma is genetically related to tumors with PHF1 rearrangements such as low-grade endometrial sarcoma and ossifying fibromyxoid tumor, but also with tumors having TFE3 rearrangements such as renal cell carcinoma, alveolar soft part sarcoma, PEComa, and epithelioid hemangioendothelioma. Further investigations on malignant chondroid syringomas are needed in order to determine whether genetic heterogeneity exists among them and the clinical impact of the PHF1-TFE3 fusion.

Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LUND-IVERSEN, M., BASSAROVA, A., HEIM, S. Tags: Article Source Type: research