Mechanistic Study of Inhibitory Effects of Atorvastatin and Docetaxel in Combination on Prostate Cancer
Conclusion: Treatment with cholesterol decreased the sensitivity of prostate cancer cells to docetaxel. Docetaxel in combination with cholesterol-lowering drugs such as atorvastatin may be an effective strategy for inhibiting the growth of prostate cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: CHEN, X., LIU, Y., WU, J., HUANG, H., DU, Z., ZHANG, K., ZHOU, D., HUNG, K., GOODIN, S., ZHENG, X. Tags: Article Source Type: research
GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification
Conclusion: GeneGazer is a reliable and robust toolkit for the analysis of data from high-throughput platforms and has potential for clinical application and biomedical research. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: LUO, J.-D., CHANG, Y.-J., CHANG, C.-M., YOU, J.-F., WEI, P.-L., CHIOU, C.-C. Tags: Article Source Type: research
Molecular Basis of Lung Tropism of Metastasis
A predilection of metastasis to the lungs has been noted for several types of cancer. Herein, we summarize underlying mechanisms for lung tropism of metastasis. We discuss the identification of a gene signature in primary breast tumors predicting metastasis to the lungs, as well as functional validation of selected genes of the signature. We outline the contribution of pre- and metastatic niches, the role of exosomes, activation of disseminated, dormant tumor cells and selected tumor–stromal cell interactions to lung metastasis and colonization. We also refer to metastasis-mediating mechanisms based on alterations of...
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUGER, R. Tags: Article Source Type: research
Identification of Prognostically Relevant Chromosomal Abnormalities in Routine Diagnostics of Multiple Myeloma Using Genomic Profiling
Conclusion: oaCGH analysis is a valuable asset in detecting prognostically relevant genomic abnormalities. The combination of oaCGH data with ISS staging might help define new sub-groups in MM. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 24, 2016 Category: Cancer & Oncology Authors: KJELDSEN, E. Tags: Article Source Type: research
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance
Conclusion: Our data-driven approach demonstrates that the variation in the expression of TRP channel genes is manifested across various human cancer types and genes, for certain TRP channels have strong predictive diagnostic and prognostic potential. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: PARK, Y. R., CHUN, J. N., SO, I., KIM, H. J., BAEK, S., JEON, J.-H., SHIN, S.-Y. Tags: Article Source Type: research
Epidermal Growth Factor Receptor (EGFR) and Keratin 5 (K5): Versatile Keyplayers Defining Prognostic and Therapeutic Sub-classes of Head and Neck Squamous Cell Carcinomas
Molecular classifications of several malignancies are already accepted and applied in clinical practice. For head and neck squamous cell carcinomas (HNSCCs) there exist few and controversial data regarding their stratification on distinct groups or sub-groups and thus, none of them are validated as useful tools for diagnosis and therapy. Starting from the highly expressed markers in HNSCC (epidermal growth factor receptor, keratin 5 and E cadherin) we proposed to identify distinct HNSCC sub-groups with a potential impact on prognosis and therapy. Complex analysis of immunohistochemical expression for six surrogate markers ...
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: CIMPEAN, A. M., BALICA, R. A., DOROS, I. C., BALICA, N. C., GAJE, P. N., POPOVICI, R. A., RAICA, M. Tags: Article Source Type: research
The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia
Conclusion: The FEN1 rs174538 A allele is a protective biomarker for childhood ALL and this association is more significant in males and in patients at onset age of 3.5 years or older. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: PEI, J.-S., CHANG, W.-S., HSU, P.-C., TSAI, C.-W., HSU, C.-M., JI, H.-X., HSIAO, C.-L., HSU, Y.-N., BAU, D.-T. Tags: Article Source Type: research
Identification of Endogenous Controls for Use in miRNA Quantification in Human Cancer Cell Lines
Conclusion: We identified a single and a pair of miRNAs suitable for use as endogenous controls when performing qPCR-based miRNA expression analyses in human cancer cell lines. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: DAS, M. K., ANDREASSEN, R., HAUGEN, T. B., FURU, K. Tags: Article Source Type: research
Potential Salivary Proteomic Markers of Oral Squamous Cell Carcinoma
Discussion: Searching for potential biomarkers among differently expressed peptides is a challenge requiring for appropriate strategies that still remain to be defined. A number of factors may potentially impair results, e.g.: (i) a group's definition for adequate comparison; (ii) reduction of data dimensionality and selection of variables to be tested in predictive models; (iii) selection of the biostatistical tool for predictive models. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: GALLO, C., CIAVARELLA, D., SANTARELLI, A., RANIERI, E., COLELLA, G., LO MUZIO, L., LO RUSSO, L. Tags: Article Source Type: research
A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum
Conclusion: Since MPS1 is involved in cell division, DNA repair, and ribosomal biogenesis, it may be a useful antigen for studying processes such as protein synthesis, oncogenesis, regeneration, aging, and perhaps diseases of the human cerebellum. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: FERNANDEZ-POL, J. A. Tags: Article Source Type: research
WNT/{beta}-catenin Signaling Pathway and Downstream Modulators in Low- and High-grade Glioma
Conclusion: Expression of WNT3a, cytoplasmic β-catenin and TCF4 was significantly associated with the histological malignancy grade and with a worse prognosis for patients with glioma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: DENYSENKO, T., ANNOVAZZI, L., CASSONI, P., MELCARNE, A., MELLAI, M., SCHIFFER, D. Tags: Article Source Type: research
Raising an Antibody Specific to Breast Cancer Subpopulations Using Phage Display on Tissue Sections
Conclusion: Further studies characterizing this antibody fragment, the subpopulation it binds and the cognate antigen may unearth novel biomarkers of clinical relevance. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: LARSEN, S. A., MELDGAARD, T., FRIDRIKSDOTTIR, A. J. R., LYKKEMARK, S., POULSEN, P. C., OVERGAARD, L. F., PETERSEN, H. B., PETERSEN, O. W., KRISTENSEN, P. Tags: Article Source Type: research
A Low-density Antigen Array for Detection of Disease-associated Autoantibodies in Human Plasma
Conclusion: The evaluated antigen array has potential as a simple method for determining the presence/absence of up to 90 disease-associated autoantibodies in a plasma specimen. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: SOMIARI, R. I., SUTPHEN, R., RENGANATHAN, K., RUSSELL, S., PASTWA, E., SOMIARI, S. A. Tags: Article Source Type: research
Molecular Mechanisms of Bone Metastasis
We describe the identification and validation of genes mediating bone metastasis by use of pre-clinical models of bone metastasis. Additionally, we discuss the role of small integrin binding N-linked glycoproteins (SIBLINGS), the chemokine/chemokine receptor CXCL12/CXCR4 pathway and the role of micro RNAs (miRNAs) as mediators of bone metastasis. Finally, we summarize clinical achievements for the treatment of bone metastases. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2015 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., KOLLMORGEN, G., RUGER, R. Tags: Article Source Type: research
Index
(Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 5, 2015 Category: Cancer & Oncology Tags: Article Source Type: research
