PRIMA-1MET Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma Cells
Conclusion: PRIMA-1MET may potentially be an alternative anticancer agent that might lead to a better prognosis in patients with CCA. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: PIYAWAJANUSORN, C., KITTIRAT, Y., SA-NGIAMWIBOOL, P., TITAPUN, A., LOILOME, W., NAMWAT, N. Tags: Article Source Type: research
Genotyping KRAS and EGFR Mutations in Greek Patients With Non-small-cell Lung Cancer: Incidence, Significance and Implications for Treatment
Conclusion: The presence of KRAS mutations is an independent negative prognosticator among Greek NSCLC patients and an independent response predictor to first line treatment. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: LINARDOU, H., KOTOULA, V., KOUVATSEAS, G., MOUNTZIOS, G., KARAVASILIS, V., SAMANTAS, E., KALOGERA-FOUNTZILA, A., TELEVANTOU, D., PAPADOPOULOU, K., MAVROPOULOU, X., DASKALAKI, E., ZARAMBOUKAS, T., EFSTRATIOU, I., LAMPAKI, S., RALLIS, G., RES, E., SYRIGOS, Tags: Article Source Type: research
Synergism of Adipocytokine Profile and ADIPOQ/TNF-{alpha} Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth
Conclusion: Obesity and hepatic steatosis significantly favor the development of colorectal cancer liver metastases and the individual adipocytokines genetic profile may play an important predictive role. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: DIVELLA, R., DANIELE, A., DE LUCA, R., MAZZOCCA, A., RUGGIERI, E., SAVINO, E., CASAMASSIMA, P., SIMONE, M., SABBA, C., PARADISO, A. Tags: Article Source Type: research
Acquisition of Invasiveness by Breast Adenocarcinoma Cells Engages Established Hallmarks and Novel Regulatory Mechanisms
Conclusion: Our data emphasize a broad systemic regulation of invasiveness, and describe the network of this regulation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: MOUSA, H., ELGAMAL, M., MAREI, R. G., SOUCHELNYTSKYI, N., LIN, K.-W., SOUCHELNYTSKYI, S. Tags: Article Source Type: research
The FOXC2 Transcription Factor Promotes Melanoma Outgrowth and Regulates Expression of Genes Associated With Drug Resistance and Interferon Responsiveness
Conclusion: FOXC2 drives a tumor-promoting gene expression program in melanoma and is a prognostic indicator of patient response to multiple cancer therapies. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: HARGADON, K. M., GYORFFY, B., STRONG, E. W., TARNAI, B. D., THOMPSON, J. C., BUSHHOUSE, D. Z., JOHNSON, C. E., WILLIAMS, C. J. Tags: Article Source Type: research
Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma
Conclusion: CDX2 promotes resistance to paclitaxel and sensitivity to 5-FU. Novel 5-FU-based chemotherapy based on CDX2 may be used in ovarian mucinous carcinoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: KOH, I., NOSAKA, S., SEKINE, M., SUGIMOTO, J., HIRATA, E., KUDO, Y. Tags: Article Source Type: research
Seeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of Arginine Analogs Inhibiting CASTOR1
Conclusion: Norarginine and Nα-acetyl-arginine are the top drug candidates for mTORC1 inhibition, with Nα-acetyl-arginine being the best choice. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: SUN, L., LI, X., PAN, J., MAO, J., YUAN, Y., WANG, D., SUN, W., KRUEGER, G. R. F., WANG, G. Tags: Article Source Type: research
Pancreatic Ductal Adenocarcinoma: MicroRNAs Affecting Tumor Growth and Metastasis in Preclinical In Vivo Models
Patients with pancreatic ductal adenocarcinoma have a dismall prognosis because at the time of diagnosis, in the vast majority of patients the tumor has already disseminated to distant organs and the therapeutic benefit of approved agents such as gemcitabine is limited. Therefore, the identification and preclinical and clinical validation of therapeutic agents covering new targets is of paramount importance. In this review we have summarized microRNAs and corresponding targets which affect growth and metastasis of pancreatic tumors in preclinical mouse in vivo models. We identified four up-regulated and 16 down-regulated m...
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., NOPORA, A. Tags: Article Source Type: research
Cell Cycle Regulator p27 Mediates Body Mass Index Effects in Ovarian Cancer in FIGO-stages I-II
Conclusion: The cell cycle regulator p27 mediates BMI effects in ovarian cancer in FIGO-stages I-II. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: SKIRNISDOTTIR, I., AKERUD, H., SEIDAL, T., SUNDSTROM-POROMAA, I. Tags: Article Source Type: research
MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation
Conclusion: miR-362-3p mediates the transcriptional regulation of hERG and is associated with survival in breast cancer. The potential for miR-362-3p to serve as a biomarker and inform therapeutic strategies warrants further investigation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: ASSIRI, A. A., MOURAD, N., SHAO, M., KIEL, P., LIU, W., SKAAR, T. C., OVERHOLSER, B. R. Tags: Article Source Type: research
Whole Transcriptomic Analysis of Apigenin on TNF{alpha} Immuno-activated MDA-MB-231 Breast Cancer Cells
Conclusion: There is a possible therapeutic role for apigenin in down-regulating diverse genes associated with tumorigenic leukocyte sub-population infiltration by triple-negative breast cancer. The data have been deposited into the Gene Expression Omnibus for public analysis at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120550. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: BAUER, D., MAZZIO, E., SOLIMAN, K. F. A. Tags: Article Source Type: research
MyD88 Regulates LPS-induced NF-ĸB/MAPK Cytokines and Promotes Inflammation and Malignancy in Colorectal Cancer Cells
Conclusion: MyD88-regulated LPS/NF-ĸB/MAPK signaling pathway affects the inflammatory and biological behavior of LPS-induced colorectal cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: ZHU, G., CHENG, Z., LIN, C., HOFFMAN, R. M., HUANG, Y., SINGH, S. R., ZHENG, W., YANG, S., YE, J. Tags: Article Source Type: research
Identification of Novel Fusion Transcripts in Undifferentiated Pleomorphic Sarcomas by Transcriptome Sequencing
Conclusion: Screening for the presence of fusion transcripts will provide vital clues to the understanding of genetic alterations and the finding of new targeted therapies for UPS. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: ZHENG, B., ZHANG, S., CAI, W., WANG, J., WANG, T., TANG, N., SHI, Y., LUO, X., YAN, W. Tags: Article Source Type: research
Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism
Conclusion: GPD1 and MAGL might be promising tissue-based protein biomarkers with a predictive potential for BC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: YONETEN, K. K., KASAP, M., AKPINAR, G., GUNES, A., GUREL, B., UTKAN, N. Z. Tags: Article Source Type: research
Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer
Conclusion: Mts1 is associated with aggressive pathological features in thyroid cancer, and may be a poor prognostic factor for thyroid cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - August 28, 2019 Category: Cancer & Oncology Authors: CHEON, M. G., SON, Y. W., LEE, J.-H., JANG, H. H., CHUNG, Y. S. Tags: Article Source Type: research
