Targeted Sequencing of Circulating Cell Free DNA Can Be Used to Monitor Therapeutic Efficacy of Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer Patients
Conclusion: The mutation count of tumor-specific mutations can be a monitoring marker of TKI treatment in NSCLC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: CHIOU, C.-C., WANG, C.-L., LUO, J.-D., LIU, C.-Y., KO, H.-W., YANG, C.-T. Tags: Article Source Type: research
Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide
Conclusion: Through this comprehensive approach, the present study illustrated the scheme of how NO affects molecular events in lung cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: MAIUTHED, A., PRAKHONGCHEEP, O., CHANVORACHOTE, P. Tags: Article Source Type: research
Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma
Conclusion: CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: UEDA, S., KANDA, M., SATO, Y., BABA, H., NAKAMURA, S., SAWAKI, K., SHIMIZU, D., MOTOYAMA, S., FUJII, T., KODERA, Y., NOMOTO, S. Tags: Article Source Type: research
Fusion of the COL4A5 Gene With NR2F2-AS1 in a Hemangioma Carrying a t(X;15)(q22;q26) Chromosomal Translocation
Conclusion: The involvement of COL4A5 indicates that some hemangiomas have pathogenetic similarities with other benign tumors such as leiomyomas and subungual exostosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LOBMAIER, I., ANDERSEN, K., LUND-IVERSEN, M., MICCI, F., HEIM, S. Tags: Article Source Type: research
Lys05 - A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective
Conclusion: This work contributes to emerging phosphoproteomic insights into autophagy-mediated global signaling in lung cancer cells, which might consequently facilitate the development of precision medicine therapeutics. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: ONDREJ, M., CECHAKOVA, L., FABRIK, I., KLIMENTOVA, J., TICHY, A. Tags: Article Source Type: research
NONO Is a Negative Regulator of SOX2 Promoter
Conclusion: These results suggest that NONO acts as a key regulator of SOX2 transcription through the repression of SOX2 promoter activity in breast cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: LIANG, S., TAKAHASHI, H., HIROSE, T., KURAMITSU, Y., HATAKEYAMA, S., YOSHIYAMA, H., WANG, R., HAMADA, J.-I., IIZASA, H. Tags: Article Source Type: research
Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
Conclusion: The clinical potential of ERB against DDLPS is herein presented in a PDOX model. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: IGARASHI, K., KAWAGUCHI, K., KIYUNA, T., MIYAKE, K., HIGUCHI, T., YAMAMOTO, N., HAYASHI, K., KIMURA, H., MIWA, S., SINGH, S. R., TSUCHIYA, H., HOFFMAN, R. M. Tags: Article Source Type: research
Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model
Epidemiological and clinical studies support the association between nutrition and development or progression of different malignancies such as colon, breast, and prostate cancer, defining these tumors as diet-associated cancer. The Mediterranean diet shows inverse associations with metabolic diseases, cardiovascular pathologies and various types of cancer. Many bioactive nutrients of the Mediterranean diet have been identified as factors protective against these types of pathologies. The epigenome has been identified as the primary goal of modulations in gene expression related to these molecular nutrients. In fact, they ...
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: DIVELLA, R., DANIELE, A., SAVINO, E., PARADISO, A. Tags: Article Source Type: research
Identification of MicroRNAs With In Vivo Efficacy in Multiple Myeloma-related Xenograft Models
Conclusion: We identified six up-regulated and twelve down-regulated miRs, which deserve further preclinical validation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 22, 2020 Category: Cancer & Oncology Authors: WEIDLE, U. H., NOPORA, A. Tags: Article Source Type: research
Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer
Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: HAN, G. H., CHAY, D. B., NAM, S., CHO, H., CHUNG, J.-Y., KIM, J.-H. Tags: Article Source Type: research
The Role of Circulating Adiponectin and SNP276G>T at ADIPOQ Gene in BRCA-mutant Women
Conclusion: In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: DANIELE, A., PARADISO, A. V., DIVELLA, R., DIGENNARO, M., PATRUNO, M., TOMMASI, S., PILATO, B., TUFARO, A., BARONE, M., MINOIA, C., COLANGELO, D., SAVINO, E., CASAMASSIMA, P., BRUNO, E., OLIVERIO, A., PASANISI, P. Tags: Article Source Type: research
The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ)
Conclusion: Not only the tumor genome, but also the germline sequence must be analysed to depict the overall genetic profile, providing potential therapeutic strategies for personalized medicine. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: HUANG, K. C.-Y., CHIANG, S.-F., KE, T.-W., CHEN, W. T.-L., CHEN, T.-W., CHAO, K.-S. C. Tags: Article Source Type: research
Prognostic Biomarkers in Early-stage Gastric Adenocarcinoma Treated With Adjuvant Chemoradiotherapy
Conclusion: PTEN protein expression and KRAS mutations may predict disease outcome in early-stage gastric cancer. These results need to be further validated in larger cohorts. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: PECTASIDES, E., CHATZIDAKIS, I., KOTOULA, V., KOLIOU, G.-A., PAPADOPOULOU, K., GIANNOULATOU, E., GIANNOUZAKOS, V. G., BOBOS, M., PAPAVASILEIOU, C., CHRISAFI, S., FLOROU, A., PECTASIDES, D., FOUNTZILAS, G. Tags: Article Source Type: research
Co-occurrent Alterations of Alzheimer's Genes and Prostate Cancer Genes in Prostate Cancer
Conclusion: The severity of prostate cancer is determined by the genetics of the tumor itself, possibly at least in part by the interactions of SPOP/BIN1, MYC/BIN1 and SPTA1/CD2AP. Oncologists treats higher grade prostate cancer with more ADT, which serves as a surrogate marker for disease severity. A weakness of our study is that we did not examine Alzheimer's disease or dementia at all in patients with cancer, only co-occurrence of genetic alterations. Nevertheless, our analysis of TCGA data does not support the idea that ADT causes Alzheimer's disease or dementia. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H. Tags: Article Source Type: research
Proteomics-based Predictive Model for the Early Detection of Metastasis and Recurrence in Head and Neck Cancer
Conclusion: The translation of proteomic predictive models to routine clinical practice may contribute to a more precise and individualized clinical management of the HNSCC patients, reducing recurrences and improving patients' quality of life. The capability of generalization of this proteomic model to predict the recurrence and metastases development should be evaluated and validated in other HNSCC populations. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: RIBEIRO, I. P., ESTEVES, L., ANJO, S. I., MARQUES, F., BARROSO, L., MANADAS, B., CARREIRA, I. M., MELO, J. B. Tags: Article Source Type: research
