Transcriptome Alterations in Liver Metastases of Colorectal Cancer After Acquired Resistance to Cetuximab
Conclusion: Our study contributes to deciphering the molecular mechanisms of acquired resistance to cetuximab. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: LI, Z., CHEN, Y., REN, W., HU, S., TAN, Z., WANG, Y., CHEN, Y., ZHANG, J., WU, J., LI, T., XU, J., YING, X. Tags: Article Source Type: research
Opposite Prognostic Impact of Single PTEN-loss and PIK3CA Mutations in Early High-risk Breast Cancer
Conclusion: In EBC, PTEN-loss is an independent predictor of poor outcome. When occurring singly, PTEN-loss and PIK3CA mutations have opposite prognostic impact. In HER2-positive disease, assessment of PTEN-loss by IHC appears unreliable and the marker is without clear prognostic significance. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: LAZARIDIS, G., KOTOULA, V., VRETTOU, E., KOSTOPOULOS, I., MANOUSOU, K., PAPADOPOULOU, K., GIANNOULATOU, E., BOBOS, M., SOTIROPOULOU, M., PENTHEROUDAKIS, G., EFSTRATIOU, I., PAPOUDOU-BAI, A., PSYRRI, A., CHRISTODOULOU, C., GOGAS, H., KOUTRAS, A., TIMOTHEAD Tags: Article Source Type: research
Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome
Conclusion. DDR1 expression is altered in ccRCC, but our findings do not support its oncogenic role. In-depth investigation will be necessary to elucidate the exact role and potential utility of miR-199a/b-5p in ccRCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: KRAZINSKI, B. E., KIEWISZ, J., SLIWINSKA-JEWSIEWICKA, A., KOWALCZYK, A. E., GRZEGRZOLKA, J., GODLEWSKI, J., KWIATKOWSKI, P., DZIEGIEL, P., KMIEC, Z. Tags: Article Source Type: research
Molecular Genetic Characterization of Acute Myeloid Leukemia With Trisomy 4 as the Sole Chromosome Abnormality
Conclusion: The results suggest a possible association between trisomy 4 and additional mutations that may influence prognosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: TORKILDSEN, S., GORUNOVA, L., HEIM, S., TJONNFJORD, G. E., SPETALEN, S., RISBERG, B., TRAN, H. T. T., PANAGOPOULOS, I. Tags: Article Source Type: research
Transcriptomic Characterization, Chemosensitivity and Regulatory Effects of Exosomes in Spontaneous EMT/MET Transitions of Breast Cancer Cells
Conclusion: This is an appropriate model for studying EMT/MET transitions, drug targets and the role of exosomes in breast cancer dissemination. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: BIGAGLI, E., CINCI, L., D'AMBROSIO, M., LUCERI, C. Tags: Article Source Type: research
Gene Expression Comparison Between the Primary Tumor and its Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma: A Pilot Study
Conclusion: Differential gene expression levels in node metastases compared to the primary tumor is linked to the prognosis of HNSCC patients. The histological/immunohisto-chemical characteristics of the tumor are associated with these genes expression changes. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: KARPATHIOU, G., STACHOWITZ, M.-L., DUMOLLARD, J. M., GAVID, M., FROUDARAKIS, M., PRADES, J. M., PEOC'H, M. Tags: Article Source Type: research
Increased RNA Expression of von Willebrand Factor Gene Is Associated With Infiltrating Lobular Breast Cancer and Normal PAM50 Subtype
Conclusion: Our finding of significantly higher VWF RNA expression in the PAM50 normal (non-basal-like) breast cancer subtype suggests that VWF protein measurement might complement or corroborate PAM50 results. VWF and PAM50 results both suggesting a low risk of recurrence might make the decision whether to give chemotherapy easier, especially if VWF protein were an independent predictor. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: LEHRER, S., GREEN, S., DEMBITZER, F. R., RHEINSTEIN, P. H., ROSENZWEIG, K. E. Tags: Article Source Type: research
MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy
Conclusion: miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 7, 2019 Category: Cancer & Oncology Authors: AHMAD, P., SANA, J., SLAVIK, M., GURIN, D., RADOVA, L., GABLO, N. A., KAZDA, T., SMILEK, P., HORAKOVA, Z., GAL, B., HERMANOVA, M., SLAMPA, P., SLABY, O. Tags: Article Source Type: research
Serum Proteomic Signatures of Male Breast Cancer
Conclusion: These findings provide valuable insight into the distinct clinicopathological features of MBC and indicate that select serum proteomic markers may help improve MBC management. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 7, 2019 Category: Cancer & Oncology Authors: ZOGRAFOS, E., ANAGNOSTOPOULOS, A. K., PAPADOPOULOU, A., LEGAKI, E., ZAGOURI, F., MARINOS, E., TSANGARIS, G. T., GAZOULI, M. Tags: Article Source Type: research
Correlation of TERT and Stem Cell Markers in the Context of Human Breast Cancer
Conclusion: The evidence presented in this article of possible interactions between TERT and a discrete subset of known stem cell markers would significantly contribute to further enquiries regarding clonal dynamics in the context of human breast cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 7, 2019 Category: Cancer & Oncology Authors: WAZIR, U., ORAKZAI, M. M. A. W., MARTIN, T. A., JIANG, W. G., MOKBEL, K. Tags: Article Source Type: research
MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer
The death toll of non-small cell lung cancer (NSCLC) patients is primarily due to metastases, which are poorly amenable to therapeutic intervention. In this review we focus on miRs associated with metastasis of NSCLC as potential new targets for anti-metastatic therapy. We discuss miRs validated as therapeutic targets by in vitro data, identification of target(s) and pathway(s) and in vivo efficacy data in at least one clinically-relevant metastasis-related model. A few of the discussed miRs correlate with the clinical status of NSCLC patients. Using miRs as therapeutic agents has the advantage that targeting a single miR ...
Source: Cancer Genomics and Proteomics - March 7, 2019 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., NOPORA, A. Tags: Article Source Type: research
Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or TET2 Mutation?
Conclusion: TET2 mutation appeared not to have additional effects when combined with SF3B1, and patients with double mutation appeared to have at least as, good as or even better prognosis than patients with isolated mutation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: SONG, J., MOSCINSKI, L., ZHANG, H., ZHANG, X., HUSSAINI, M. Tags: Article Source Type: research
A Comprehensive Proteome Analysis of Peripheral Blood Mononuclear Cells (PBMCs) to Identify Candidate Biomarkers of Pancreatic Cancer
Conclusion: A PBMCs proteome with extensive protein representation was achieved, which will potentially allow the identification of novel biomarkers for PC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: LI, H., MAO, Y., XIONG, Y., ZHAO, H. H., SHEN, F., GAO, X., YANG, P., LIU, X., FU, D. Tags: Article Source Type: research
MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 via PAX3
Conclusion: Overexpression of miR-1 suppressed cell proliferation and induced arrest in the G0/G1 phase by increasing p21 levels via a p53-independent pathway through PAX3 suppression. These results indicate that miR-1 could be a therapeutic target for osteosarcoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: FUJII, R., OSAKA, E., SATO, K., TOKUHASHI, Y. Tags: Article Source Type: research
Three Poliovirus Sequences in the Human Genome Associated With Colorectal Cancer
Conclusion: Poliovirus sequences in the human genome may contribute to programmed cell death and lysis of colorectal cancer cells. A recombinant poliovirus, incapable of reverting to neurovirulence, might be given orally at intervals as a colorectal cancer vaccine to prevent colorectal cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H. Tags: Article Source Type: research
