MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 via PAX3

Conclusion: Overexpression of miR-1 suppressed cell proliferation and induced arrest in the G0/G1 phase by increasing p21 levels via a p53-independent pathway through PAX3 suppression. These results indicate that miR-1 could be a therapeutic target for osteosarcoma.

http://cgp.iiarjournals.org/cgi/content/short/16/1/71?rss=1

Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: FUJII, R., OSAKA, E., SATO, K., TOKUHASHI, Y. Tags: Article Source Type: research