Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (SLC18A1) in Lung Cancer
Conclusion: Most never-smokers with lung cancer do not respond to immune checkpoint inhibitors (ICIs). But for unknown reasons, a small proportion do show clinical benefit from the ICI pembrolizumab. Because of the good response of this group, it may be worthwhile assessing their SLC18A1 expression pre-treatment as a marker for potential clinical benefit. If SLC18A1 expression is low, a never-smoker may respond well to ICIs. High levels of expression would indicate a C5 tumor less likely to respond to ICIs. SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/progra...
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H. Tags: Article Source Type: research
Pyrosequencing Analysis of MGMT Promoter Methylation in Meningioma
Conclusion: The methylation of the MGMT promoter is uncommon, or occurs at a low frequency in meningiomas. There is no convincing rationale to test such tumors for their MGMT methylation status in a clinical setting. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LESKE, H., NIEHUSMANN, P., JOHANNESSEN, L. E., STAURSETH, J., OINO, N., MELING, T. R., HEIM, S., MICCI, F., BRANDAL, P. Tags: Article Source Type: research
Copy Number Alterations in Tumor Genomes Deleting Antineoplastic Drug Targets Partially Compensated by Complementary Amplifications
Conclusion: Deletions of AN target proteins can be compensated by amplification of alternative targets. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: TRAN, H. V., KIEMER, A. K., HELMS, V. Tags: Article Source Type: research
Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A
Conclusion: TSA does not alter HDAC transcripts nor BRAF itself, but down-regulates critical components of the MAPK/MEK/BRAF oncogenic pathway, initiating a mitotic arrest. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 7, 2018 Category: Cancer & Oncology Authors: MAZZIO, E. A., SOLIMAN, K. F. A. Tags: Article Source Type: research
A Comprehensive Method for Detecting Fusion Genes in Paediatric Brain Tumours
Conclusion: A comprehensive method for detecting fusion genes in paediatric brain tumours was evaluated. This method identified KIAA1549–BRAF fusion variants quickly. Our results may help researchers interested in the role of fusion genes in tumourigenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: KONDO, A., SHIMIZU, Y., ADACHI, S., OGINO, I., SUZUKI, M., AKIYAMA, O., ARAI, H. Tags: Article Source Type: research
Proteomic Analysis of Pelvic Autonomic Nerve in Nerve-sparing Radical Hysterectomy for Cervical Carcinoma
Conclusion: Further large studies are expected to present more nerve-specific candidate proteins which can be used for the easy and safe identification of autonomic nerves. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: LEE, Y. H., KIM, M. K., MOON, H. Y., CHONG, G. O., LEE, H. J., LEE, Y. S., PARK, J. Y., LEE, C. H., BAEK, M. C., HONG, D. G. Tags: Article Source Type: research
Leptin Receptor Antagonists' Action on HDAC Expression Eliminating the Negative Effects of Leptin in Ovarian Cancer
Conclusion: SHLA and Lan2 eliminate the negative effects of leptin on HDAC expression in a cell-type-dependent manner. This is the first report testing leptin receptor blockers as HDAC inhibitors in ovarian cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: FIEDOR, E., ZAJDA, K., GREGORASZCZUK, E. L. Tags: Article Source Type: research
Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection
Blood plasma microRNAs (miRNAs) are emerging as a clinically useful tool for non-invasive detection and prognosis estimation in various cancer types including pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to provide an independent validation of circulating miRNAs identified in previous studies as diagnostic and/or prognostic biomarkers in PDAC. Based on the literature search, 6 miRNAs were chosen as candidates for independent validation; miR-21-5p, miR-375, miR-155, miR-17-5p, miR-126-5p and miR-1290. Validation of these miRNAs was performed in a cohort of 25 patients with PDAC undergoing surgic...
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: KARASEK, P., GABLO, N., HLAVSA, J., KISS, I., VYCHYTILOVA-FALTEJSKOVA, P., HERMANOVA, M., KALA, Z., SLABY, O., PROCHAZKA, V. Tags: Article Source Type: research
Overexpression of FGFR1 Promotes Peritoneal Dissemination Via Epithelial-to-Mesenchymal Transition in Gastric Cancer
Conclusion: High FGFR1 expression was associated with PD via promotion of EMT and led to a poor prognosis of GC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: SHIMIZU, D., SAITO, T., ITO, S., MASUDA, T., KURASHIGE, J., KURODA, Y., EGUCHI, H., KODERA, Y., MIMORI, K. Tags: Article Source Type: research
Identification and Quantification of Heterogeneously-methylated DNA Fragments Using Epiallele-sensitive Droplet Digital Polymerase Chain Reaction (EAST-ddPCR)
Conclusion: All individual heterogeneously-methylated epialleles were quantifiable by a set of fluorescence-labeled probes with complementary sequences to epialleles in a closed-tube and high-throughput manner. The new method named epiallele-sensitive droplet digital PCR (EAST-ddPCR) may give new insights in the generation and regulation of epialleles and may help in finding new biomarkers for the diagnosis of benign und malignant diseases. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: MENSCHIKOWSKI, M., JANDECK, C., FRIEDEMANN, M., RICHTER, S., THIEM, D., LANGE, B. S., SUTTORP, M. Tags: Article Source Type: research
Comparing Clonality Between Components of Combined Hepatocellular Carcinoma and Cholangiocarcinoma by Targeted Sequencing
Conclusion: Based on our study, cHCC-CC can be genetically divided into biclonal and monoclonal forms. Therefore, separate sequencing of each component of cHCC-CC is recommended for exact molecular classification and targeted therapy. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: JEON, J., MAENG, L.-S., BAE, Y. J., LEE, E.-J., YOON, Y. C., YOON, N. Tags: Article Source Type: research
Comparative Secretome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteomics
Conclusion: This is the first proteogenomics study in PCa aiming at exploring a new type of metastatic factor, which are mutant peptides, predicting a novel biomarker of metastatic PCa for diagnosis, prognosis and drug targeting. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: KWON, O. K., JEON, J. M., SUNG, E., NA, A.-Y., KIM, S. J., LEE, S. Tags: Article Source Type: research
Glioblastoma Multiforme: Fewer Tumor Copy Number Segments of the SGK1 Gene Are Associated with Poorer Survival
Conclusion: Increased median overall survival associated with increased SGK1 copy number segments may be a reflection of better tumor oxygenation. Therefore, besides being a drug target, SGK1 may also be a prognostic marker. Among molecular tumor markers, only the methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene has shown a significant association with survival in patients with GBM. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H., ROSENZWEIG, K. E. Tags: Article Source Type: research
Frequency of Mismatch Repair Protein Deficiency in a Puerto Rican Population with Colonic Adenoma and Adenocarcinoma
Conclusion: When compared to prior reports, this study suggests a lower frequency of MSI among the Puerto Rican population. The higher prevalence of MLH1 mutations correlates with previous studies of protein expression among the Hispanic community including Colombian, Uruguay and Brazilian populations. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: REVERON, D., LOPEZ, C., GUTIERREZ, S., SAYEGH, Z. E., ANTONIA, T., DUTIL, J., MALAFA, M., COPPOLA, D. Tags: Article Source Type: research
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response
In conclusion, these findings suggest that a primary target of YM-155 is the loss of replicative DNA repair systems. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: MAZZIO, E. A., LEWIS, C. A., ELHAG, R., SOLIMAN, K. F. Tags: Article Source Type: research
