The Dual PI3K/mToR Inhibitor Omipalisib/GSK2126458 Inhibits Clonogenic Growth in Oncogenically-transformed Cells from Neurocutaneous Melanocytosis
Conclusion: Signaling through Akt is important for survival of clonogenic cells in NCM, and omipalisib treatment as a monotherapy or in combination with MEK162 could be an effective therapeutic strategy to inhibit clonogenic growth. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: BASU, D., SALGADO, C. M., BAUER, B., KHAKOO, Y., PATEL, J. R., HOEHL, R. M., BERTOLINI, D. M., ZABEC, J., BRZOZOWSKI, M. R., REYES-MUGICA, M. Tags: Article Source Type: research
Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter {alpha}-Trypsin Inhibitors
In this review we summarize the principles of anti-metastatic therapy with selected serpin family proteins, such as pigment epithelial-derived factor (PEDF) and maspin, as well as inter α-trypsin inhibitor (IαIs) light chains (bikunin) and heavy chains (ITIHs). Case-by-case, antimetastatic activity may be dependent or independent of the protease-inhibitory activity of the corresponding proteins. We discuss the incidence of target deregulation in different tumor entities, mechanisms of deregulation, context-dependent functional issues as well as in vitro and in vivo target validation studies with transfected tum...
Source: Cancer Genomics and Proteomics - July 5, 2018 Category: Cancer & Oncology Authors: WEIDLE, U. H., BIRZELE, F., TIEFENTHALER, G. Tags: Article Source Type: research
Establishment and Characteristics of a Novel Mantle Cell Lymphoma-derived Cell Line and a Bendamustine-resistant Subline
Conclusion: BH resistance is mediated by overlapping mechanisms with overexpression of ABCB1 and MGST1, and is potentially accompanied by multidrug resistance in MCL. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: TAKIMOTO-SHIMOMURA, T., NAGOSHI, H., MAEGAWA, S., FUJIBAYASHI, Y., TSUKAMOTO, T., MATSUMURA-KIMOTO, Y., MIZUNO, Y., CHINEN, Y., MIZUTANI, S., SHIMURA, Y., HORIIKE, S., TANIWAKI, M., KOBAYASHI, T., KURODA, J. Tags: Article Source Type: research
The Contribution of MMP-7 Genotypes to Colorectal Cancer Susceptibility in Taiwan
Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: YUEH, T.-C., WU, C.-N., HUNG, Y.-W., CHANG, W.-S., FU, C.-K., PEI, J.-S., WU, M.-H., LAI, Y.-L., LEE, Y.-M., YEN, S.-T., LI, H.-T., TSAI, C.-W., BAU, D.-T. Tags: Article Source Type: research
EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas
In this report, we present the case of a 38-year-old female with a locally-invasive and unresectable SPN that, despite exhaustive chemoradiotherapy, progressed to liver metastasis. Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21. This finding, if confirmed in additional cases of metastatic SPN, would support preoperative testing for EGFR mutation analysis to detect aggressive SPNs. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: NEILL, K. G., SALLER, J., AL DIFFALHA, S., CENTENO, B. A., MALAFA, M. P., COPPOLA, D. Tags: Article Source Type: research
Cytogenetics of Spindle Cell/Pleomorphic Lipomas: Karyotyping and FISH Analysis of 31 Tumors
Conclusion: Structural rearrangements of 13q or losses of an entire chromosome 13 are the most common cytogenetic aberrations in spindle cell/pleomorphic lipomas. However, cytogenetic variation exists similarly to what is found in other lipomas, suggesting that various pathways may be responsible for tumorigenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LUND-IVERSEN, M., ANDERSEN, K., ANDERSEN, H. K., LOBMAIER, I., BJERKEHAGEN, B., HEIM, S. Tags: Article Source Type: research
Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans
Conclusion: Disruption of notch 1 mediated-repression of RACGAP1 may contribute to PCa in African Americans. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: WILSON, B. D., RICKS-SANTI, L. J., MASON, T. E., ABBAS, M., KITTLES, R. A., DUNSTON, G. M., KANAAN, Y. M. Tags: Article Source Type: research
HIF-1{alpha} and mTOR - Possible Novel Strategies of Targeted Therapies in p16-positive and -negative HNSCC
Conclusion: This is the first study to investigate the alteration of expression levels of HIF-1α and mTOR under selective tyrosine kinase inhibition in both p16-positive and -negative SCC. Our findings provide novel insights for a better understanding of HIF-1α and mTOR in the tumor biology of HNSCC and their interaction with selective small-molecule inhibitors. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: KRAMER, B., POLIT, M., BIRK, R., ROTTER, N., ADERHOLD, C. Tags: Article Source Type: research
Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma
Conclusion: The downstream of LMO1-regulatory cascade includes a tumor-promoting LIMS1/ILK pathway, which has a potential to be a novel therapeutic target. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: SAEKI, N., SAITO, A., SUGAYA, Y., AMEMIYA, M., ONO, H., KOMATSUZAKI, R., YANAGIHARA, K., SASAKI, H. Tags: Article Source Type: research
Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors
Primary lung neuroendocrine tumors (NETs) consist of typical and atypical carcinoids, large-cell neuroendocrine carcinomas and small-cell lung carcinomas. NETs are highly heterogeneous in histological characteristics, clinical presentation and natural history. While there are morphological and immunohistochemical criteria to establish diagnosis, there is a lack of universal consensus for prognostic factors or therapeutic targets for personalized treatment of the disease. Thus, identifying potential markers of neuroendocrine differentiation and prognostic factors remains of high importance. This review provides an insight i...
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: MORIS, D., NTANASIS-STATHOPOULOS, I., TSILIMIGRAS, D. I., ADAM, M. A., YANG, C. J., HARPOLE, D., THEOCHARIS, S. Tags: Article Source Type: research
LINE-1 ORF1 Protein Is Up-regulated by Reactive Oxygen Species and Associated with Bladder Urothelial Carcinoma Progression
Conclusion: Elevated ORF1p expression is associated with tumor progression. ROS experimentally induce ORF1p expression and promote migration in bladder cancer cells. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: WHONGSIRI, P., PIMRATANA, C., WIJITSETTAKUL, U., JINDATIP, D., SANPAVAT, A., SCHULZ, W. A., HOFFMANN, M. J., GOERING, W., BOONLA, C. Tags: Article Source Type: research
ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance
Conclusion: ILK overexpression in human CRC associates with EMT and CSC traits, contributing to tumor progression and chemoresistance. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: TSOUMAS, D., NIKOU, S., GIANNOPOULOU, E., TSANIRAS, S. C., SIRINIAN, C., MAROULIS, I., TARAVIRAS, S., ZOLOTA, V., KALOFONOS, H. P., BRAVOU, V. Tags: Article Source Type: research
Genetic Landscape of Acute Myeloid Leukemia Interrogated by Next-generation Sequencing: A Large Cancer Center Experience
Conclusion: The genetic heterogeneity of AML signifies the importance of taking a personalized-medicine approach to the management of patients with AML. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: HUSSAINI, M. O., MIRZA, A.-S., KOMROKJI, R., LANCET, J., PADRON, E., SONG, J. Tags: Article Source Type: research
Novel Germline PTEN Mutation Associated with Cowden Syndrome and Osteosarcoma
Conclusion: We report a patient with CS presenting with ganglioneuromatosis, benign breast mass and osteosarcoma, harboring a novel molecular alteration in PTEN which to our knowledge has not been previously reported. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: LOPEZ, C., ABUEL-HAIJA, M., PENA, L., COPPOLA, D. Tags: Article Source Type: research
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5
Acquisition of resistance to topoisomerase I (TOP1)-targeting camptothecin (CPT) derivatives is a major clinical problem. Little is known about the underlying chromosomal and genomic mechanisms. We characterized the CPT-K5 cell line expressing mutant CPT-resistant TOP1 and its parental T-cell derived acute lymphoblastic leukemia CPT-sensitive RPMI-8402 cell line by karyotyping and molecular genetic methods, including subtractive oligo-based array comparative genomic hybridization (soaCGH) analysis. Karyotyping revealed that CPT-K5 cells had acquired additional structural aberrations and a reduced modal chromosomal number c...
Source: Cancer Genomics and Proteomics - March 1, 2018 Category: Cancer & Oncology Authors: KJELDSEN, E., NIELSEN, C. J. F., ROY, A., TESAURO, C., JAKOBSEN, A.-K., STOUGAARD, M., KNUDSEN, B. R. Tags: Article Source Type: research
