EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas

In this report, we present the case of a 38-year-old female with a locally-invasive and unresectable SPN that, despite exhaustive chemoradiotherapy, progressed to liver metastasis. Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21. This finding, if confirmed in additional cases of metastatic SPN, would support preoperative testing for EGFR mutation analysis to detect aggressive SPNs.

Source: Cancer Genomics and Proteomics - April 25, 2018 Category: Cancer & Oncology Authors: NEILL, K. G., SALLER, J., AL DIFFALHA, S., CENTENO, B. A., MALAFA, M. P., COPPOLA, D. Tags: Article Source Type: research