Tumor microRNAs Identified by Small RNA Sequencing as Potential Response Predictors in Locally Advanced Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy
Conclusion: By combination of miRNA expression profiling and integrative computational biology we identified miR-487a-3p as a potential predictive biomarker of CRT response in LARC patients. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: MACHACKOVA, T., TRACHTOVA, K., PROCHAZKA, V., GROLICH, T., FARKASOVA, M., FIALA, L., SEFR, R., KISS, I., SKROVINA, M., DOSOUDIL, M., BERINDAN-NEAGOE, I., SVOBODA, M., SLABY, O., KALA, Z. Tags: Article Source Type: research
NDRG1-PLAG1 and TRPS1-PLAG1 Fusion Genes in Chondroid Syringoma
Conclusion: The NDRG1-PLAG1 and TRPS1-PLAG1 resemble other PLAG1 fusion genes inasmuch as the expression of PLAG1 comes under the control of the NDRG1 or TRPS1 promoter. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., ANDERSEN, K., LUND-IVERSEN, M., LOBMAIER, I., MICCI, F., HEIM, S. Tags: Article Source Type: research
Putative Biomarkers for Malignant Pleural Mesothelioma Suggested by Proteomic Analysis of Cell Secretome
Conclusion: A panel of the putative biomarkers represents a promising tool for MPM diagnosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: LACERENZA, S., CIREGIA, F., GIUSTI, L., BONOTTI, A., GRECO, V., GIANNACCINI, G., D'ANTONGIOVANNI, V., FALLAHI, P., PIERONI, L., CRISTAUDO, A., LUCACCHINI, A., MAZZONI, M. R., FODDIS, R. Tags: Article Source Type: research
A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
Conclusion: 3Pt is a promising clinical candidate for the treatment of recalcitrant osteosarcoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - April 27, 2020 Category: Cancer & Oncology Authors: IGARASHI, K., KAWAGUCHI, K., YAMAMOTO, N., HAYASHI, K., KIMURA, H., MIWA, S., HIGUCHI, T., TANIGUCHI, Y., YONEZAWA, H., ARAKI, Y., MORINAGA, S., MISRA, S., NELSON, S. D., DRY, S. M., LI, Y., ODANI, A., SINGH, S. R., TSUCHIYA, H., HOFFMAN, R. M. Tags: Article Source Type: research
Genetic Association Analysis of Cell Cycle Regulators Reveals YWHAZ Has Prognostic Significance in Prostate Cancer
Conclusion: YWHAZ rs2290291 was found to be associated with BCR. YWHAZ may function as a putative oncogene during prostate cancer progression. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: YU, C.-C., CHEN, L.-C., LIN, W.-H., LIN, V. C., HUANG, C.-Y., LU, T.-L., LEE, C.-H., HUANG, S.-P., BAO, B.-Y. Tags: Article Source Type: research
Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics
Conclusion: SRM was significantly increased depending on the cancer stage, confirming the possibility of using SRM as a biomarker for prognosis and prediction of advanced PCa. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: KWON, O. K., HA, Y.-S., NA, A.-Y., CHUN, S. Y., KWON, T. G., LEE, J. N., LEE, S. Tags: Article Source Type: research
Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer
Conclusion: There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: NIKOLAIDI, A., KOTOULA, V., KOLIOU, G.-A., GIANNOULATOU, E., PAPADOPOULOU, K., ZAGOURI, F., PENTHEROUDAKIS, G., GOGAS, H., BOBOS, M., CHATZOPOULOS, K., OIKONOMOPOULOS, G., PECTASIDES, D., SALOUSTROS, E., ARNOGIANNAKI, N., NICOLAOU, I., PAPAKOSTAS, P., BOM Tags: Article Source Type: research
Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan
Conclusion: MiR146a rs2910164 G allele serves as a protective marker for childhood ALL in Taiwan. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: PEI, J.-S., CHANG, W.-S., HSU, P.-C., CHEN, C.-C., CHIN, Y.-T., HUANG, T.-L., HSU, Y.-N., KUO, C.-C., WANG, Y.-C., TSAI, C.-W., GONG, C.-L., BAU, D.-T. Tags: Article Source Type: research
Stratification Using hTERT and Stem Cell Markers Confers a Good Prognosis in Invasive Breast Cancer
Conclusion: This panel of genes stratified by hTERT could open new avenues for the development of new prognostic tools, as well as for the identification of new research directions regarding breast oncogenesis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: WAZIR, U., TAYEH, S., ORAKZAI, M. A. W., MARTIN, T. A., JIANG, W. G., MOKBEL, K. Tags: Article Source Type: research
FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma
Conclusion: Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3’-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., LOBMAIER, I., ANDERSEN, K., KOSTOLOMOV, I., LUND-IVERSEN, M., BJERKEHAGEN, B., HEIM, S. Tags: Article Source Type: research
Clonal Relationship Between Lichen Sclerosus, Differentiated Vulvar Intra-epithelial Neoplasia and Non HPV-related Vulvar Squamous Cell Carcinoma
Conclusion: Our data provide genetic evidence for a clonal relationship between VSCC and dVIN or LS. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: POUWER, A.-F. W., VAN DEN EINDEN, L. C. G., VAN DER LINDEN, M., HEHIR-KWA, J. Y., YU, J., HENDRIKS, K. M., KAMPING, E. J., EIJKELENBOOM, A., MASSUGER, L. F. A. G., BULTEN, J., VAN TILBORG, A. A. G., DE HULLU, J. A., KUIPER, R. P. Tags: Article Source Type: research
KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: KITAGAWA, A., MASUDA, T., TAKAHASHI, J., TOBO, T., NODA, M., KURODA, Y., HU, Q., KOUYAMA, Y., KOBAYASHI, Y., KURAMITSU, S., SATO, K., FUJII, A., YOSHIKAWA, Y., WAKIYAMA, H., SHIMIZU, D., TSURUDA, Y., EGUCHI, H., DOKI, Y., MORI, M., MIMORI, K. Tags: Article Source Type: research
Pazopanib Inhibits Tumor Growth, Lymph-node Metastasis and Lymphangiogenesis of an Orthotopic Mouse of Colorectal Cancer
Conclusion: PAZ can inhibit the growth of colorectal cancer and inhibit lymph node metastasis and lymphangiogenesis in orthotopic colon cancer nude mouse models. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: ZHU, G., ZHAO, M., HAN, Q., TAN, Y., SUN, Y., BOUVET, M., SINGH, S. R., YE, J., HOFFMAN, R. M. Tags: Article Source Type: research
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma
Conclusion: To our knowledge, the present report is one of the first described gene-orphan case studies of a pediatric spinal cord pilocytic astrocytoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: MARTINELLI, C., GABRIELE, F., MANAI, F., CICCONE, R., NOVARA, F., SAUTA, E., BELLAZZI, R., PATANE, M., MORONI, I., PATERRA, R., COMINCINI, S. Tags: Article Source Type: research
Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress
Conclusion: Defects in components of non-B structure suppression systems (e.g. p53 helicase targeting) promote replication-linked damage selectively targeted to sequences prone to G-quadruplex and i-motif formation. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - February 26, 2020 Category: Cancer & Oncology Authors: AMPARO, C., CLARK, J., BEDELL, V., MURATA-COLLINS, J. L., MARTELLA, M., PICHIORRI, F., WARNER, E. F., ABDELHAMID, M. A. S., WALLER, Z. A. E., SMITH, S. S. Tags: Article Source Type: research
