DEK-NUP214-Fusion Identified by RNA-Sequencing of an Acute Myeloid Leukemia with t(9;12)(q34;q15)
Conclusion: RNA-sequencing proved to be a valuable tool for the detection of a fusion of genes DEK and NUP214 in a leukemia that showed cryptic cytogenetic rearrangement of chromosome band 9q34. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., TORKILDSEN, S., TJONNFJORD, G. E., MICCI, F., HEIM, S. Tags: Reviews Source Type: research
Screening for Multiple Autoantibodies in Plasma of Patients with Breast Cancer
Conclusion: Disease-relevant autoantibodies were detected in the plasma of patients with breast cancer and donors without breast cancer. This means that identifying the type and level of autoantibodies in samples will be important in determining their significance in the disease process. A microtiter plate-based array system could be a fast and inexpensive screening method for identifying and quantifying autoantibodies in human plasma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: BASSARO, L., RUSSELL, S. J., PASTWA, E., SOMIARI, S. A., SOMIARI, R. I. Tags: Reviews Source Type: research
Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death
Conclusion: The anti-cancer effects of the historically used frankincense sap (BSE) appear to involve major impact on the ER/UPR response, concomitant to effecting multiple targets counter to the growth, proliferation and metastasis of TNBC cancer cells. The microarray data are available at Expression Omnibus GEO Series accession number GSE102891. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: MAZZIO, E. A., LEWIS, C. A., SOLIMAN, K. F. A. Tags: Reviews Source Type: research
Impact of Mediterranean Diet on Cancer: Focused Literature Review
Conclusion: The MediD is associated with reduction in overall cancer rates as well as significantly lower rates of digestive tract cancers. These effects may be accentuated in the Mediterranean countries themselves. Further studies are needed to support or refute the effects of the MediD on other cancer types. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - November 6, 2017 Category: Cancer & Oncology Authors: BARAK, Y., FRIDMAN, D. Tags: Reviews Source Type: research
Post-transcriptional Regulation of MMP16 and TIMP2 Expression via miR-382, miR-410 and miR-200b in Endometrial Cancer
Conclusion: We demonstrated novel mechanisms of miRNA-mediated regulation of MMPs activity in EC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: RAK, B., MEHLICH, D., GARBICZ, F., DOMOSUD, Z., PASKAL, W., MARCZEWSKA, J. M., WŁODARSKI, P. K. Tags: Experimental Studies Source Type: research
Evaluation of Podoplanin Expression in Hepatocellular Carcinoma Using RNAscope and Immunohistochemistry - A Preliminary Report
Conclusion: Our preliminary results suggest that PDPN contributes to the malignant potential of HCC. RNAscope proved to be a more sensitive and reliable method than IHC in PDPN detection. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: CIOCA, A., CIMPEAN, A. M., CEAUSU, R. A., TARLUI, V., TOMA, A., MARIN, I., RAICA, M. Tags: Experimental Studies Source Type: research
miR18a and miR19a Recruit Specific Proteins for Splicing in Thyroid Cancer Cells
Conclusion: miRNA processing depends on cell-specific proteins and heterogeneous nuclear proteins have a general role in miRNA processing from introns. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: PAIVA, M. M., KIMURA, E. T., COLTRI, P. P. Tags: Experimental Studies Source Type: research
Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study
Conclusion: The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in TCGT. We confirmed that finding in our cohort study, which represents the first report of changed RASSF1A promoter methylation in peripheral blood TGCT. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: MARKULIN, D., VOJTA, A., SAMARŽIJA, I., GAMULIN, M., BEČEHELI, I., JUKIĆ, I., MAGLOV, ČEDOMIR, ZOLDOŠ, V., FUČIĆ, A. Tags: Experimental Studies Source Type: research
Trichostatin A Sensitizes Hepatocellular Carcinoma Cells to Enhanced NK Cell-mediated Killing by Regulating Immune-related Genes
Conclusion: TSA likely increases killing of HCC cells indirectly by increasing NK cell-directed killing and directly by increasing apoptosis. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: SHIN, S., KIM, M., LEE, S.-J., PARK, K.-S., LEE, C. H. Tags: Experimental Studies Source Type: research
Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step
Conclusion: We demonstrated that mutational rates for APC and KRAS differ between colitic cancer and sporadic CRC. Furthermore, we revealed that CDH1 and FGFR2 become mutated at an earlier stage in colitic carcinogenesis than in sporadic CRC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: TANAKA, T., KOBUNAI, T., YAMAMOTO, Y., EMOTO, S., MURONO, K., KANEKO, M., SASAKI, K., OTANI, K., NISHIKAWA, T., KAWAI, K., HATA, K., NOZAWA, H., WATANABE, T. Tags: Experimental Studies Source Type: research
Low Levels of Microsatellite Instability at Simple Repeated Sequences Commonly Occur in Human Hepatocellular Carcinoma
Conclusion: Based on a large series of HCC with various etiologies, our study allowed us to definitely conclude that MSI is not a hallmark of HCC. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: GOUMARD, C., DESBOIS-MOUTHON, C., WENDUM, D., CALMEL, C., MERABTENE, F., SCATTON, O., PRAZ, F. Tags: Experimental Studies Source Type: research
Chemical Proteomic Approaches Targeting Cancer Stem Cells: A Review of Current Literature
Cancer stem cells (CSCs) have been proposed as central drivers of tumor initiation, progression, recurrence, and therapeutic resistance. Therefore, identifying stem-like cells within cancers and understanding their properties is crucial for the development of effective anticancer therapies. Recently, chemical proteomics has become a powerful tool to efficiently determine protein networks responsible for CSC pathophysiology and comprehensively elucidate molecular mechanisms of drug action against CSCs. This review provides an overview of major methodologies utilized in chemical proteomic approaches. In addition, recent succ...
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: JUNG, H. J. Tags: Reviews Source Type: research
Histone Deacetylases as New Therapeutic Targets in Triple-negative Breast Cancer: Progress and Promises
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR) and HER2 gene. It comprises approximately 15-20% of breast cancers (BCs). Unfortunately, TNBC's treatment continues to be a clinical problem because of its relatively poor prognosis, its aggressiveness and the lack of targeted therapies, leaving chemotherapy as the mainstay of treatment. It is essential to find new therapies against TNBC, in order to surpass the resistance and the invasiveness of already existing therapies. Given the fact that epigenetic processes control both the initiation and progression of TNBC, ...
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: GARMPIS, N., DAMASKOS, C., GARMPI, A., KALAMPOKAS, E., KALAMPOKAS, T., SPARTALIS, E., DASKALOPOULOU, A., VALSAMI, S., KONTOS, M., NONNI, A., KONTZOGLOU, K., PERREA, D., NIKITEAS, N., DIMITROULIS, D. Tags: Reviews Source Type: research
The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2
In this study, we present a review on the phylogenesis of BRCA1 and BRCA2. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: PFEFFER, C. M., HO, B. N., SINGH, A. T. K. Tags: Reviews Source Type: research
Comparative miRNA Expression Profile Analysis of Squamous Cell Carcinoma and Peritumoral Mucosa from the Meso- and Hypopharynx
Conclusion: miRNA expression analysis was found to be appropriate for molecular segregation of tumor location and peritumoral tissue segments, and appears to be a promising marker for cancer field characterization. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - June 24, 2017 Category: Cancer & Oncology Authors: OROSZ, E., GOMBOS, K., RIEDLING, T., AFIAKURUE, P., KISS, I., PYTEL, J., GERLINGER, I., SZANYI, I. Tags: Article Source Type: research
