Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step

Conclusion: We demonstrated that mutational rates for APC and KRAS differ between colitic cancer and sporadic CRC. Furthermore, we revealed that CDH1 and FGFR2 become mutated at an earlier stage in colitic carcinogenesis than in sporadic CRC.

Source: Cancer Genomics and Proteomics - September 4, 2017 Category: Cancer & Oncology Authors: TANAKA, T., KOBUNAI, T., YAMAMOTO, Y., EMOTO, S., MURONO, K., KANEKO, M., SASAKI, K., OTANI, K., NISHIKAWA, T., KAWAI, K., HATA, K., NOZAWA, H., WATANABE, T. Tags: Experimental Studies Source Type: research