The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets

We present an overview on metastasis-promoting, -suppressing and context-dependent miRs with both activities. We have categorized the corresponding miRs according to their target classes, interaction with stromal cells or exosomes. The pathways affected by individual miRs are outlined in regard to in vitro properties, activity in metastasis-related in vivo models and clinical significance. Current approaches that may be suitable for therapeutic inhibition or restauration of miR activity are outlined. Finally, we discuss the delivery bottlenecks which present as a major challenge in nucleic acid (miR)-based therapies.

Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: WEIDLE, U. H., DICKOPF, S., HINTERMAIR, C., KOLLMORGEN, G., BIRZELE, F., BRINKMANN, U. Tags: Article Source Type: research