2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells

Conclusion: Herein, mitochondrial biogenesis pathway regulation and SDHA were presented as novel targets of 2-ME, and moreover, 2-ME was demonstrated as a potent inhibitor of SIRT3. L-lactate was confirmed to exert pro-carcinogenic effects on osteosarcoma cells via the induction of the mitochondrial biogenesis pathway. Thus, L-lactate level may be considered as a prognostic biomarker for osteosarcoma.

Source: Cancer Genomics and Proteomics - December 23, 2017 Category: Cancer & Oncology Authors: GORSKA-PONIKOWSKA, M., KUBAN-JANKOWSKA, A., EISLER, S. A., PERRICONE, U., LO BOSCO, G., BARONE, G., NUSSBERGER, S. Tags: Article Source Type: research