Pediatric Ependymoma: A Proteomics Perspective

Conclusion: Through the proposed nanoLC-MS/MS method herein we report, for the firs time, the ependymoma proteome database. A large number of similarities regarding proteome content are revealed compared to other two pediatric brain tumor entities; astrocytomas and medulloblastomas. Furthermore, through our approach, the majority of currently proposed markers for ependymoma (e.g. nucleolin, nestin, Ki67 and laminin subunit A2) as well as all major key players of the phosphoinositide 3-kinase pathway (seemingly implicated in ependymoma), were definitely detected.

Source: Cancer Genomics and Proteomics - March 16, 2017 Category: Cancer & Oncology Authors: TSANGARIS, G. T., PAPATHANASIOU, C., ADAMOPOULOS, P. G., SCORILAS, A., VORGIAS, C. E., PRODROMOU, N., STATHOPOULOU, F. T., STRAVOPODIS, D. J., ANAGNOSTOPOULOS, A. K. Tags: Article Source Type: research