Promotion of Cellular Growth and Motility Is Independent of Enzymatic Activity of Fibroblast Activation Protein-{alpha}

Conclusion: Promotion of cellular growth and motility is independent of the enzymatic activity of FAPα in breast cancer cells. The PI3K/AKT and MMP2/9 signaling pathways might be involved in such regulation.

Source: Cancer Genomics and Proteomics - April 21, 2016 Category: Cancer & Oncology Authors: LV, B., XIE, F., ZHAO, P., MA, X., JIANG, W. G., YU, J., ZHANG, X., JIA, J. Tags: Article Source Type: research