Differential Expression of Aquaporins in Cervical Precursor Lesions and Invasive Cervical Cancer
Conclusions:
Different AQP isoforms display specific expression patterns in normal cervical, CIN, and SCC tissues. This and the significant association with the clinicopathologic variables of SCC suggest that AQP isoforms might play different roles in the development of cervical cancer. (Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Shen, Q., Lin, W., Luo, H., Zhao, C., Cheng, H., Jiang, W., Zhu, X. Tags: Original Articles Source Type: research
Chymotrypsin Enhances Soluble Fms-Like Tyrosine Kinase 1 Production Through Protease-Activated Receptor 2 in Placenta-Derived Immortalized Human Trophoblast Cells
The production of soluble fms-like tyrosine kinase 1 (sFLT1) by exogenous chymotrypsin in trophoblast cells through protease-activated receptor (PAR) 2 was investigated to identify the role of a chymotrypsin-like serine protease in preeclampsia (PE) pathogenesis. We evaluated the expression of chymotrypsin, FLT1, and sFLT1 in monolayers of immortalized human trophoblast cells derived from placenta (TCL-1 cells). To investigate whether chymotrypsin enhances the production and release of sFLT1 through PAR-2, we examined changes in sFLT1 protein levels in conditioned medium by enzyme-linked immunosorbent assay and sFLT1 messe...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Hirai, C., Sugimura, M., Makino, S., Takeda, S. Tags: Original Articles Source Type: research
The Effect of Levonorgestrel on Fibrinolytic Factors in Human Endometrial Endothelial Cells
Conclusions:
Levonorgestrel decreases tPA levels through the androgen receptor in HEECs. Thus, LNG inhibits tPA secretion by the endometrial endothelial cell. This response suggests reduction in HMB with LNG-IUS could reflect an LNG-mediated promotion of hemostasis. (Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Pakrashi, T., Taylor, J. E., Nelson, A., Archer, D. F., Jacot, T. Tags: Original Articles Source Type: research
Emodin Inhibits Migration and Invasion of Human Endometrial Stromal Cells by Facilitating the Mesenchymal-Epithelial Transition Through Targeting ILK
Conclusion:
Emodin inhibits the migration and invasion abilities of human ESCs by facilitating the MET through targeting ILK. (Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Zheng, Q., Xu, Y., Lu, J., Zhao, J., Wei, X., Liu, P. Tags: Original Articles Source Type: research
Endothelin Receptor A Antagonism Prevents Damage to Glycogen-Rich Placental Cells Following Uterine Ischemia-Reperfusion in the Rat
Fetal growth restriction (FGR) is a common cause of perinatal morbidity and mortality. Suboptimal uteroplacental perfusion is the most commonly identified cause of FGR, and ischemic lesions are often observed in placentas from pregnancies complicated by FGR. Ischemia followed by reperfusion is a strong stimulus to the production of the vasoconstrictor endothelin 1 (ET-1) which has been implicated in several models of FGR. We sought to investigate oxidative stress and placental morphology in a rat model of ischemia–reperfusion (I/R)-induced FGR and to evaluate the role of ET-1 in the observed pathology. Unilateral ute...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Thaete, L. G., Khan, S., Neerhof, M. G. Tags: Original Articles Source Type: research
Supplementation With Cell-Penetrating Peptide-Conjugated Estrogen-Related Receptor {beta} Improves the Formation of the Inner Cell Mass and the Development of Vitrified/Warmed Mouse Embryos
This study shows for the first time that recombinant CPP-ESRRB can be easily integrated into vitrified/warmed mouse embryos and that it increases Oct4 expression (via a pluripotency-related gene pathway), ICM formation, and the further embryonic and full-term development of vitrified/warmed mouse embryos. This CPP-conjugated protein delivery system could therefore be a useful tool for improving assisted reproductive technology. (Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Yang, N. J., Seol, D.-W., Jo, J., Jang, H. M., Yoon, S.-Y., Lee, W. S., Lee, D. R. Tags: Original Articles Source Type: research
Testicular Stem Cells Express Follicle-Stimulating Hormone Receptors and Are Directly Modulated by FSH
Testicular spermatogonial stem cells (SSCs) are a heterogeneous population of stem cells, and definitive marker for the most primitive subset that undergoes asymmetric cell division remains to be identified. A novel subpopulation of pluripotent, very small embryonic-like stem cells (VSELs) has been reported in both human and mouse testes. Follicle-stimulating hormone (FSH) receptors (FSHRs) are expressed on Sertoli cells in testis and on granulosa cells in ovary, but recently FSHRs are reported on VSELs in ovaries, bone marrow, and cord blood. The present study was aimed to investigate whether FSHRs are also expressed on t...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Patel, H., Bhartiya, D. Tags: Original Articles Source Type: research
The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer
Conclusion:
Cisplatin- and taxotere-resistant EOC cells are characterized by lower VEGF, VEGF receptors, and HIF-1α, and decreased angiogenesis. These findings may indicate a decrease in drug delivery at the tumor site, hence allowing the persistence of chemoresistant EOC cells. (Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Nusrat, O., Belotte, J., Fletcher, N. M., Memaj, I., Saed, M. G., Diamond, M. P., Saed, G. M. Tags: Original Articles Source Type: research
Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition
This study determined whether a progesterone (P) receptor (PR)-mediated mechanism regulates morphological characteristics associated with prepartum cervix remodeling at term and with preterm birth. With focus on the transition from a soft to ripe cervix, the cervix stroma of untreated controls had reduced cell nuclei density/area and less organized extracellular collagen, while the density of macrophages/area, but not neutrophils, increased just 2 days before birth (day 17 vs day 15 or 16.5 postbreeding). Preterm birth was induced within 24 hours of treatment on day 16 postbreeding with PR antagonist or ovariectomy (Ovx). ...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Kirby, M. A., Heuerman, A. C., Custer, M., Dobyns, A. E., Strilaeff, R., Stutz, K. N., Cooperrider, J., Elsissy, J. G., Yellon, S. M. Tags: Original Articles Source Type: research
Risk of Respiratory Distress Syndrome and Efficacy of Glucocorticoids: Are They the Same in the Normally Grown and Growth-Restricted Infant?
Administration of glucocorticoids (GCs) to women at risk of preterm delivery reduces the newborn’s risk of respiratory distress syndrome (RDS) by 35% to 40%; however, not all infants respond to this treatment. Fetal growth restriction (FGR) increases the risk of prematurity, perinatal morbidity, and mortality. This review aims to synthesize current evidence reporting the difference in RDS risk between FGR and normally grown infants (Question 1) and whether antenatal GC administration reduces the risk of RDS morbidity in FGR infants (Question 2). Systematic searches were performed, and after screening, a total of 27 a...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: McGillick, E. V., Orgeig, S., Williams, M. T., Morrison, J. L. Tags: Reviews Source Type: research
Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis
Painful bladder syndrome/interstitial cystitis is a debilitating chronic bladder disease that primarily affects women. The disease is due to a damage of urothelial cell lining. As a result, potassium particles and other toxic substances in urine can leak into bladder mucosa, causing the symptoms of lower abdominal/pelvic discomfort, pain, increased urination frequency, urgency, nocturia, and so on, all of which can substantially reduce the quality of daily life. There are multiple symptom reliving therapies. Among them, only pentosan polysulfate sodium, sold under the brand name of Elmiron, has been approved for oral use b...
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Rao, C. V. Tags: Reviews Source Type: research
Editorial
(Source: Reproductive Sciences)
Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Harding, R., Sozo, F. Tags: Editorial Source Type: research
A Novel Missense Mutation in USP26 Gene Is Associated With Nonobstructive Azoospermia
Conclusion:
A novel USP26 variant p.R344W is associated with NOA probably through affecting AR function. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Ma, Q., Li, Y., Guo, H., Li, C., Chen, J., Luo, M., Jiang, Z., Li, H., Gui, Y. Tags: Original Articles Source Type: research
The Regulation of Fatty Acid Oxidation in Human Preeclampsia
Preeclampsia (PE) is a pregnancy disorder characterized by high blood pressure, placental oxidative stress, and proteinuria. In a GeneFishing experiment using human preeclamptic placenta, expression of acyl-coenzyme A dehydrogenase very long chain (ACADVL), which is involved in fatty acid β-oxidation (FAO), was detected. To investigate the correlation between PE and FAO, this study subjected in vitro BeWo cells and in vivo pregnant mice to oxidative stress induced by hypoxia. Hypoxic condition, which oxygen supply is insufficient in cells and placenta, created a similar state to placental oxidative stress in PE, as ev...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Shin, E.-K., Kang, H. Y., Yang, H., Jung, E.-M., Jeung, E.-B. Tags: Original Articles Source Type: research
Cellular Changes Consistent With Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons
We have recently shown that platelets play important roles in development of endometriosis and proposed that endometriotic lesions are essentially wounds that undergo repeated tissue injury and repair (ReTIAR). Further investigation indicated that endometriotic lesions, stimulated by platelet-derived transforming growth factor β1 (TGF-β1), activate the TGF-β1/Smad3 signaling pathway and undergo epithelial–mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT), resulting in increased cellular contractility and collagen production and increased smooth muscle metaplasia (S...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Zhang, Q., Duan, J., Olson, M., Fazleabas, A., Guo, S.-W. Tags: Original Articles Source Type: research
