The Effect of Levonorgestrel on Fibrinolytic Factors in Human Endometrial Endothelial Cells

Conclusions:
Levonorgestrel decreases tPA levels through the androgen receptor in HEECs. Thus, LNG inhibits tPA secretion by the endometrial endothelial cell. This response suggests reduction in HMB with LNG-IUS could reflect an LNG-mediated promotion of hemostasis.

Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Pakrashi, T., Taylor, J. E., Nelson, A., Archer, D. F., Jacot, T. Tags: Original Articles Source Type: research