Supplementation With Cell-Penetrating Peptide-Conjugated Estrogen-Related Receptor {beta} Improves the Formation of the Inner Cell Mass and the Development of Vitrified/Warmed Mouse Embryos

This study shows for the first time that recombinant CPP-ESRRB can be easily integrated into vitrified/warmed mouse embryos and that it increases Oct4 expression (via a pluripotency-related gene pathway), ICM formation, and the further embryonic and full-term development of vitrified/warmed mouse embryos. This CPP-conjugated protein delivery system could therefore be a useful tool for improving assisted reproductive technology.

Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Yang, N. J., Seol, D.-W., Jo, J., Jang, H. M., Yoon, S.-Y., Lee, W. S., Lee, D. R. Tags: Original Articles Source Type: research