Mouse Ovarian Very Small Embryonic-Like Stem Cells Resist Chemotherapy and Retain Ability to Initiate Oocyte-Specific Differentiation
This study was undertaken to investigate stem cells in adult mouse ovary, the effect of chemotherapy on them and their potential to differentiate into germ cells. Very small embryonic-like stem cells (VSELs) that were SCA-1+/Lin–/CD45–, positive for nuclear octamer-binding transforming factor 4 (OCT-4), Nanog, and cell surface stage-specific embryonic antigen 1, were identified in adult mouse ovary. Chemotherapy resulted in complete loss of follicular reserve and cytoplasmic OCT-4 positive progenitors (ovarian germ stem cells) but VSELs survived. In ovarian surface epithelial (OSE) cell cultures from chemoablat...
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Sriraman, K., Bhartiya, D., Anand, S., Bhutda, S. Tags: Original Articles Source Type: research
Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications
This study was undertaken to test the hypotheses that, due to gradual accumulation of dead erythrocytes and their ingested products resulting from repeated hemorrhage, older endometriomas (whitish in color) contain chocolate fluid with higher iron content than younger (brownish/blackish in color) ones with concomitant higher collagen content and more adhesions. We recruited 30 premenopausal women with histologically confirmed ovarian endometriomas and collected samples of their endometriotic lesions and chocolate fluid and measured the viscosity, density, and the concentration of total bilirubin, ferritin, and free iron of...
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Guo, S.-W., Ding, D., Shen, M., Liu, X. Tags: Original Articles Source Type: research
Regulation of the Renin-Angiotensin System Pathways in the Human Decidua
Pregnancy outcome is influenced, in part, by the sex of the fetus. Decidual renin messenger RNA (REN) abundance is greater in women carrying a female fetus than a male fetus. Here, we explore whether the sex of the fetus also influences the regulation of decidual RAS expression with a known stimulator of renal renin and cyclic adenosine monophosphate (cAMP). Cyclic adenosine monophosphate had no affect on decidual REN expression, since REN abundance was still greater in decidual explants from women carrying a female fetus than a male fetus after cAMP treatment. Cyclic adenosine monophosphate decreased prorenin levels in th...
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Wang, Y., Lumbers, E. R., Sykes, S. D., Pringle, K. G. Tags: Original Articles Source Type: research
The Effect of an Obesogenic Maternal Environment on Expression of Fetal Umbilical Cord Blood miRNA
Conclusion:
Expression of fetal miRNA is not altered in umbilical cord blood in response to in utero exposure to obesity. Alternate mechanisms underlying the fetal effects of maternal obesity should be explored. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Ghaffari, N., Parry, S., Elovitz, M. A., Durnwald, C. P. Tags: Original Articles Source Type: research
Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation
Conclusion:
Measuring circulating proinflammatory mRNA in women with PPROM may distinguish those with chorioamnionitis from those without, in turn providing better targeted therapies and appropriate timing of delivery. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 23, 2015 Category: Reproduction Medicine Authors: Stock, O., Gordon, L., Kapoor, J., Walker, S. P., Whitehead, C., Kaitu'u-Lino, T. J., Pell, G., Hannan, N. J., Tong, S. Tags: Original Articles Source Type: research
